Literature DB >> 35322806

Targeted protein degraders: a call for collective action to advance safety assessment.

Lyn H Jones, Constance A Mitchell, Lise Loberg, Mira Pavkovic, Mohan Rao, Ruth Roberts, Katie Stamp, Laurie Volak, Matthias B Wittwer, Syril Pettit.   

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Year:  2022        PMID： 35322806     DOI： 10.1038/d41573-022-00055-9

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  5 in total

1.  Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.

Authors:  Katherine A Donovan; Fleur M Ferguson; Jonathan W Bushman; Nicholas A Eleuteri; Debabrata Bhunia; SeongShick Ryu; Li Tan; Kun Shi; Hong Yue; Xiaoxi Liu; Dennis Dobrovolsky; Baishan Jiang; Jinhua Wang; Mingfeng Hao; Inchul You; Mingxing Teng; Yanke Liang; John Hatcher; Zhengnian Li; Theresa D Manz; Brian Groendyke; Wanyi Hu; Yunju Nam; Sandip Sengupta; Hanna Cho; Injae Shin; Michael P Agius; Irene M Ghobrial; Michelle W Ma; Jianwei Che; Sara J Buhrlage; Taebo Sim; Nathanael S Gray; Eric S Fischer
Journal:  Cell       Date:  2020-12-03       Impact factor: 41.582

Review 2.  Proteolysis-targeting chimeras in drug development: A safety perspective.

Authors:  Kevin Moreau; Muireann Coen; Andrew X Zhang; Fiona Pachl; M Paola Castaldi; Goran Dahl; Helen Boyd; Clay Scott; Pete Newham
Journal:  Br J Pharmacol       Date:  2020-02-25       Impact factor: 8.739

Review 3.  Development of targeted protein degradation therapeutics.

Authors:  Philip P Chamberlain; Lawrence G Hamann
Journal:  Nat Chem Biol       Date:  2019-09-16       Impact factor: 15.040

Review 4.  Target Validation Using PROTACs: Applying the Four Pillars Framework.

Authors:  Radosław P Nowak; Lyn H Jones
Journal:  SLAS Discov       Date:  2020-12-17       Impact factor: 3.341

Review 5.  PROTAC targeted protein degraders: the past is prologue.

Authors:  Miklós Békés; David R Langley; Craig M Crews
Journal:  Nat Rev Drug Discov       Date:  2022-01-18       Impact factor: 112.288
  5 in total
  1 in total

Review 1.  Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras.

Authors:  Chunlong Zhao; Frank J Dekker
Journal:  ACS Pharmacol Transl Sci       Date:  2022-08-22
  1 in total

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