Literature DB >> 3531908

The effect of morphine on the electrophysiological activity of the hypothalamic luteinizing hormone-releasing hormone pulse generator in the rhesus monkey.

J S Kesner, J M Kaufman, R C Wilson, G Kuroda, E Knobil.   

Abstract

In ovariectomized rhesus monkeys, the electrophysiological manifestation of luteinizing hormone-releasing hormone (LHRH) pulse generator activity was arrested by morphine and reinitiated by naloxone. These responses were noted within 1 and 2 min, respectively, after the intravenous injection of the drugs. Naloxone given alone had no effect. These results support the view that opioids modulate pulsatile gonadotropin release by an action on the hypothalamic LHRH pulse generator.

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Year:  1986        PMID： 3531908     DOI： 10.1159/000124605

Source DB:  PubMed          Journal:  Neuroendocrinology        ISSN： 0028-3835            Impact factor:   4.914


  6 in total

1.  Duration of phasic electrical activity of the hypothalamic gonadotropin-releasing hormone pulse generator and dynamics of luteinizing hormone pulses in the rhesus monkey.

Authors:  C L Williams; J C Thalabard; K T O'Byrne; P M Grosser; M Nishihara; J Hotchkiss; E Knobil
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

2.  Effects of the antidopaminergic drug veralipride on LH and PRL secretion in postmenopausal women.

Authors:  P Fioretti; A Cagnacci; A M Paoletti; M Gambacciani; R Soldani; G A Mauro; A Spinetti; G B Melis
Journal:  J Endocrinol Invest       Date:  1989-05       Impact factor: 4.256

3.  Single unit components of the hypothalamic multiunit electrical activity associated with the central signal generator that directs the pulsatile secretion of gonadotropic hormones.

Authors:  H Cardenas; T Ordög; K T O'Byrne; E Knobil
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

4.  Calcitonin gene-related peptide-induced suppression of luteinizing hormone pulses in the rat: the role of endogenous opioid peptides.

Authors:  J E Bowe; X F Li; J S Kinsey-Jones; S Paterson; S D Brain; S L Lightman; K T O'Byrne
Journal:  J Physiol       Date:  2005-05-19       Impact factor: 5.182

5.  beta-Endorphin blocks luteinizing hormone-releasing hormone release by inhibiting the nitricoxidergic pathway controlling its release.

Authors:  A G Faletti; C A Mastronardi; A Lomniczi; A Seilicovich; M Gimeno; S M McCann; V Rettori
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

6.  Estradiol and the inhibition of hypothalamic gonadotropin-releasing hormone pulse generator activity in the rhesus monkey.

Authors:  T Ordög; E Knobil
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205
  6 in total

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