Frédéric Silvestri1, Bérengère Saliba-Serre2, Michel Ruquet1, Nicolas Graillon3, Nicolas Fakhry4, Abbas Mourad5, Gérald Maille6. 1. Ecole de Médecine dentaire, Aix-Marseille Université, 27 boulevard Jean Moulin, 13005 Marseille; Pôle Odontologie, UF Prothèses, Hôpital Timone, Assistance Publique des Hôpitaux de Marseille, 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France. EFS CNRS, Faculté des Sciences Médicales et Paramédicales, UMR 7268 ADES, Aix-Marseille Université, 51 boulevard Pierre Dramard, 13944 Marseille Cedex 15, France. 2. EFS CNRS, Faculté des Sciences Médicales et Paramédicales, UMR 7268 ADES, Aix-Marseille Université, 51 boulevard Pierre Dramard, 13944 Marseille Cedex 15, France. 3. Faculté des Sciences Médicales et Paramédicales, Aix-Marseille Université, 27 boulevard Jean Moulin, 13005 Marseille; Pôle PROMO, Service de Chirurgie Maxillofaciale Stomatologie et Chirurgie Orale, Hôpital de la Conception, Assistance Publique des Hôpitaux de Marseille, 147 boulevard Baille, 13005 Marseille, France. 4. Faculté des Sciences Médicales et Paramédicales, Aix-Marseille Université, 27 boulevard Jean Moulin, 13005 Marseille; Pôle PROMO, Service ORL et Chirurgie Cervico-faciale, Hôpital de la Conception, Assistance Publique des Hôpitaux de Marseille, 147 boulevard Baille, 13005 Marseille, France. 5. UMR 912 SESSTIM, INSERM, Aix-Marseille Université, SanteRcom, Faculté des sciences médicales et paramédicales, 27 boulevard Jean Moulin, 13005 Marseille, France. 6. Ecole de Médecine dentaire, Aix-Marseille Université, 27 boulevard Jean Moulin, 13555 Marseille Cedex 5; Pôle Odontologie, UF Prothèses, Hôpital Timone, Assistance Publique des Hôpitaux de Marseille, 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France. EFS CNRS, Faculté des Sciences Médicales et Paramédicales, UMR 7268 ADES, Aix-Marseille Université, 51 boulevard Pierre Dramard, 13944 Marseille Cedex 15, France.
Abstract
Background: Head and neck cancer and its treatment cause significant functional, aesthetic, and social disabilities. These disabilities have a major impact on the quality of life of patients. When irradiation is required, removable dental prostheses are often the treatment of choice. This study investigated whether removable prosthetic rehabilitation improved patient function and aesthetics over the long term. Material and Methods: In this prospective study, we assessed quality of life in 78 patients with the General Oral Health Assessment Index (GOHAI) questionnaire. Assessments were performed before, and 1 week, 3 months, 6 months, and 12 months after denture insertion. We evaluated whether quality of life was influenced by the type of removable prosthesis and the primary tumour location. Results: We constructed mixed-effects linear regression models to identify correlates of the overall GOHAI score (GOAHI-add score) and the three domain-scores (functional, psychosocial, and discomfort/pain) in a longitudinal analysis over a 12-month follow-up. We compared scores (GOHAI-add score and domain-scores) in multivariate analyses between baseline (T0) and four post-insertion timepoints to determine significant changes. Conclusions: We found that removable prosthetic rehabilitation had an influence on the evolution of quality of life. The psychosocial component scores increased steadily over the year and changed more significantly than the functional and discomfort-pain components. The mandibular location of the primary lesion had a negative influence on quality of life. The type of removable prosthesis did not influence the results. Key words:Quality of life, head and neck cancer, GOHAI, dental prosthesis, radiotherapy. Copyright:
Background: Head and neck cancer and its treatment cause significant functional, aesthetic, and social disabilities. These disabilities have a major impact on the quality of life of patients. When irradiation is required, removable dental prostheses are often the treatment of choice. This study investigated whether removable prosthetic rehabilitation improved patient function and aesthetics over the long term. Material and Methods: In this prospective study, we assessed quality of life in 78 patients with the General Oral Health Assessment Index (GOHAI) questionnaire. Assessments were performed before, and 1 week, 3 months, 6 months, and 12 months after denture insertion. We evaluated whether quality of life was influenced by the type of removable prosthesis and the primary tumour location. Results: We constructed mixed-effects linear regression models to identify correlates of the overall GOHAI score (GOAHI-add score) and the three domain-scores (functional, psychosocial, and discomfort/pain) in a longitudinal analysis over a 12-month follow-up. We compared scores (GOHAI-add score and domain-scores) in multivariate analyses between baseline (T0) and four post-insertion timepoints to determine significant changes. Conclusions: We found that removable prosthetic rehabilitation had an influence on the evolution of quality of life. The psychosocial component scores increased steadily over the year and changed more significantly than the functional and discomfort-pain components. The mandibular location of the primary lesion had a negative influence on quality of life. The type of removable prosthesis did not influence the results. Key words:Quality of life, head and neck cancer, GOHAI, dental prosthesis, radiotherapy. Copyright:
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