Literature DB >> 35316098

Making the switch: The role of Gq in driving GRK selectivity at GPCRs.

Parishmita Sarma1, Shirsha Saha1, Arun K Shukla1.   

Abstract

Selective engagement of signal transducers such as G proteins and β-arrestins with GPCRs upon stimulation with biased agonists is thought to be due to distinct receptor conformations. Kawakami et al. propose an additional mechanism whereby activation of Gq determines GPCR kinase subtype selectivity to the activated angiotensin receptor, leading to distinct binding modalities of β-arrestins and functional outcomes.

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Year:  2022        PMID： 35316098      PMCID： PMC7612787          DOI： 10.1126/scisignal.abo4949

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   9.517


  10 in total

1.  Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms.

Authors:  Eshan Ghosh; Hemlata Dwivedi; Mithu Baidya; Ashish Srivastava; Punita Kumari; Tomek Stepniewski; Hee Ryung Kim; Mi-Hye Lee; Jaana van Gastel; Madhu Chaturvedi; Debarati Roy; Shubhi Pandey; Jagannath Maharana; Ramon Guixà-González; Louis M Luttrell; Ka Young Chung; Somnath Dutta; Jana Selent; Arun K Shukla
Journal:  Cell Rep       Date:  2019-09-24       Impact factor: 9.423

2.  Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Authors:  Thomas J Cahill; Alex R B Thomsen; Jeffrey T Tarrasch; Bianca Plouffe; Anthony H Nguyen; Fan Yang; Li-Yin Huang; Alem W Kahsai; Daniel L Bassoni; Bryant J Gavino; Jane E Lamerdin; Sarah Triest; Arun K Shukla; Benjamin Berger; John Little; Albert Antar; Adi Blanc; Chang-Xiu Qu; Xin Chen; Kouki Kawakami; Asuka Inoue; Junken Aoki; Jan Steyaert; Jin-Peng Sun; Michel Bouvier; Georgios Skiniotis; Robert J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-21       Impact factor: 11.205

3.  Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.

Authors:  Titiwat Sungkaworn; Marie-Lise Jobin; Krzysztof Burnecki; Aleksander Weron; Martin J Lohse; Davide Calebiro
Journal:  Nature       Date:  2017-10-18       Impact factor: 49.962

Review 4.  Recent developments in biased agonism.

Authors:  James W Wisler; Kunhong Xiao; Alex R B Thomsen; Robert J Lefkowitz
Journal:  Curr Opin Cell Biol       Date:  2013-11-20       Impact factor: 8.382

5.  Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.

Authors:  Kouki Kawakami; Masataka Yanagawa; Suzune Hiratsuka; Misaki Yoshida; Yuki Ono; Michio Hiroshima; Masahiro Ueda; Junken Aoki; Yasushi Sako; Asuka Inoue
Journal:  Nat Commun       Date:  2022-01-25       Impact factor: 14.919

6.  GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation.

Authors:  J Drube; R S Haider; E S F Matthees; M Reichel; J Zeiner; S Fritzwanker; C Ziegler; S Barz; L Klement; J Filor; V Weitzel; A Kliewer; E Miess-Tanneberg; E Kostenis; S Schulz; C Hoffmann
Journal:  Nat Commun       Date:  2022-01-27       Impact factor: 14.919

7.  Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein-coupled receptors.

Authors:  Mithu Baidya; Punita Kumari; Hemlata Dwivedi-Agnihotri; Shubhi Pandey; Badr Sokrat; Silvia Sposini; Madhu Chaturvedi; Ashish Srivastava; Debarati Roy; Aylin C Hanyaloglu; Michel Bouvier; Arun K Shukla
Journal:  J Biol Chem       Date:  2020-05-21       Impact factor: 5.157

8.  Functional competence of a partially engaged GPCR-β-arrestin complex.

Authors:  Punita Kumari; Ashish Srivastava; Ramanuj Banerjee; Eshan Ghosh; Pragya Gupta; Ravi Ranjan; Xin Chen; Bhagyashri Gupta; Charu Gupta; Deepika Jaiman; Arun K Shukla
Journal:  Nat Commun       Date:  2016-11-09       Impact factor: 14.919

9.  Catalytic activation of β-arrestin by GPCRs.

Authors:  Kelsie Eichel; Damien Jullié; Benjamin Barsi-Rhyne; Naomi R Latorraca; Matthieu Masureel; Jean-Baptiste Sibarita; Ron O Dror; Mark von Zastrow
Journal:  Nature       Date:  2018-05-02       Impact factor: 49.962

Review 10.  Community guidelines for GPCR ligand bias: IUPHAR review 32.

Authors:  Peter Kolb; Terry Kenakin; Stephen P H Alexander; Marcel Bermudez; Laura M Bohn; Christian S Breinholt; Michel Bouvier; Stephen J Hill; Evi Kostenis; Kirill A Martemyanov; Rick R Neubig; H Ongun Onaran; Sudarshan Rajagopal; Bryan L Roth; Jana Selent; Arun K Shukla; Martha E Sommer; David E Gloriam
Journal:  Br J Pharmacol       Date:  2022-03-27       Impact factor: 9.473
  10 in total

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