| Literature DB >> 35315795 |
Kelsey A Rankin1, Isaac G Freedman, Harold G Moore, Scott J Halperin, Lee E Rubin, Jonathan N Grauer.
Abstract
INTRODUCTION: Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are outstanding options for many older patients at the discretion of the patient and the surgeon. As patients turn 65 years, greater than 98% of the US population becomes eligible for Medicare, and this represents a time of changing healthcare coverage for many.Entities:
Mesh:
Year: 2022 PMID: 35315795 PMCID: PMC8942773 DOI: 10.5435/JAAOSGlobal-D-22-00035
Source DB: PubMed Journal: J Am Acad Orthop Surg Glob Res Rev ISSN: 2474-7661
Predictors of Age ≥65 Years as Proxy for Delaying Procedures
| Variable | Multivariate Model[ | |
| OR (95% CI) | ||
| Procedure type | ||
| THA | Referent |
|
| TKA | 1.07 (1.04-1.10) | |
| Female sex | 1.08 (1.05-1.11) |
|
| BMI (kg/m2) | ||
| <18.5 | 1.05 (0.83-1.32) | 0.675 |
| 18.5-24.9 | 1.03 (0.98-1.09) | 0.201 |
| 25-29.9 | Referent | |
| 30-34.9 | 0.99 (0.95-1.02) | 0.454 |
| ≥35 | 0.87 (0.83-0.90) |
|
| ASA class | ||
| 1 | Referent | |
| 2 | 1.10 (1.01-1.20) |
|
| 3 | 1.17 (1.07-1.28) |
|
| 4 | 1.19 (1.02-1.38) |
|
| Functional status | ||
| Independent | Referent | |
| Partially/totally dependent | 1.17 (1.02-1.35) |
|
| Race/ethnicity | ||
| Non-Hispanic White | Referent | |
| Hispanic | 0.87 (0.80-0.94) |
|
| Black or African American | 0.85 (0.80-0.89) |
|
| Asian | 0.97 (0.87-1.07) | 0.515 |
| Others | 0.89 (0.86-0.93) |
|
ASA = American Society of Anesthesiologists, BMI = body mass index, CI = confidence interval, OR = odds ratio, THA = total hip arthroplasty, TKA = total knee arthroplasty
Controlled for all significant variables from univariate analyses.
Significance set at P < 0.05.
Figure 1Graphs showing a significant jump at age 65 years in otherwise normally distributed frequency of combined arthroplasty. A, Distribution of all individuals undergoing either THA or TKA from 2012 to 2018, plotted as a function of age. Discontinuous jump is noted at age = 65 by the red dashed vertical line. B, Distribution of all individuals undergoing THA from 2012 to 2018, plotted as a function of age. Discontinuous jump is noted at age = 65 by the red dashed vertical line. C, Distribution of all individuals undergoing TKA from 2012 to 2018, plotted as a function of age. Discontinuous jump is noted at age = 65 by the red dashed vertical line. THA = total hip arthroplasty, TKA = total knee arthroplasty.
Figure 2Graph showing significant discontinuous jump in combined total arthroplasty at age 65 years: a first-order polynomial regression discontinuity plot of all individuals undergoing either TKA or THA, with discontinuity cutoff at age = 65 (P = 0.001). This demonstrates significant discontinuity at age = 65, indicating that undergoing TKA or THA after 65 years is more likely. THA = total hip arthroplasty, TKA = total knee arthroplasty.
Significantly More Patients Older Than 65 Years Are Having Elective TKA and THA
| Groups | <65 yrs, n (%) | ≥65 yrs, n (%) | |
| Combined (THA + TKA) | |||
| n = 515,139 | |||
| Age = 66.05 ± 10.21 yrs | 218,479 (41.41) | 296,660 (57.59) |
|
| THA | |||
| n = 195,507 | |||
| Age = 64.98 ± 11.32 yrs | 90,903 (46.50) | 104,604 (53.50) |
|
| TKA | |||
| n = 319,632 | |||
| Age = 66.70 ± 9.41 yrs | 127,576 (39.91) | 192,056 (60.09) |
|
THA = total hip arthroplasty, TKA = total knee arthroplasty
Significance set at P < 0.05.
Age expressed as mean ± SD.
Combined THA and TKA Show Demographic and Outcome Differences When Stratified by Medicare Eligibility
| Variable | 63-64 | 65-66 | |
| Total, n (%) | 36,511 (46.70) | 41,671 (53.30) |
|
| Sex, n (%) |
| ||
| Female | 21,046 (57.64) | 24,653 (59.16) | |
| Male | 15,465 (42.36) | 17,018 (40.84) | |
| Race/ethnicity, n (%) |
| ||
| Non-Hispanic White | 25,090 (68.72) | 29,677 (71.22) | |
| Hispanic | 1,196 (3.28) | 1,243 (2.98) | |
| Black or African American | 2,696 (7.38) | 2,714 (6.51) | |
| Asian | 660 (1.81) | 782 (1.88) | |
| Other | 6,869 (18.81) | 7,255 (17.41) | |
| BMI (kg/m2), n (%) |
| ||
| <18.5 | 132 (0.36) | 165 (0.40) | |
| 18.5-24 | 3,742 (10.25) | 4,554 (10.93) | |
| 25-29 | 9,655 (26.44) | 11,331 (27.19) | |
| 30-34 | 10,255 (28.09) | 12,040 (28.89) | |
| ≥35 | 12,727 (34.86) | 13,581 (32.59) | |
| ASA, n (%) | 0.199 | ||
| 1 | 1,005 (2.75) | 1,045 (2.51) | |
| 2 | 19,512 (53.44) | 22,151 (53.16) | |
| 3 | 15,472 (42.38) | 17,871 (42.89) | |
| 4 | 520 (1.42) | 602 (1.45) | |
| Functional status, n (%) |
| ||
| Independent | 36,159 (99.04) | 41,025 (98.88) | |
| Partially/totally dependent | 352 (0.96) | 466 (1.12) | |
| AAE, n (%) | 0.104 | ||
| No | 30,548 (83.67) | 35,044 (84.10) | |
| Yes | 5,963 (16.33) | 6,627 (15.90) | |
| SAE, n (%) | 0.302 | ||
| No | 35,329 (96.76) | 40,376 (96.89) | |
| Yes | 1,182 (3.24) | 1,295 (3.11) | |
| Discharge disposition, n (%) |
| ||
| Home | 31,215 (85.49) | 34,635 (83.12) | |
| Not home | 5,296 (14.51) | 7,036 (16.88) | |
| LOS (d) |
| ||
| Mean ± SD | 2.42 ± 1.54 | 2.43 ± 1.51 | |
| Median (IQR) | 2 (2-3) | 2 (2-3) |
AAE = any adverse event, ASA = American Society of Anesthesiologists, BMI = body mass index, IQR = interquartile range, LOS = length of stay, SAE = serious adverse event, THA = total hip arthroplasty, TKA = total knee arthroplasty
Chi square goodness-of-fit test.
Not home includes a skilled care facility, rehab facility, against medical advice, facility that was home, hospice, multilevel senior community, separate acute care, unskilled facility not home, and unknown.
Significance set at P < 0.05.
THA Shows Demographic, Comorbid, Discharge Destination, and LOS Differences When Stratified by Medicare Eligibility
| Variable | 63-64 | 65-66 | |
| Total, n (%) | 13,080 (47.35) | 14,543 (52.65) |
|
| Sex, n (%) |
| ||
| Female | 7,119 (54.43) | 8,252 (56.74) | |
| Male | 5,961 (45.57) | 6,291 (43.26) | |
| Race/ethnicity, n (%) |
| ||
| Non-Hispanic White | 9,353 (71.51) | 10,651 (73.24) | |
| Hispanic | 276 (2.11) | 257 (1.77) | |
| Black or African American | 915 (7.00) | 958 (6.59) | |
| Asian | 161 (1.23) | 218 (1.50) | |
| Other | 2,375 (18.16) | 2,459 (16.91) | |
| BMI (kg/m2), n (%) |
| ||
| <18.5 | 97 (0.74) | 124 (0.85) | |
| 18.5-24 | 2,225 (17.01) | 2,617 (17.99) | |
| 25-29 | 4,216 (32.23) | 4,750 (32.66) | |
| 30-34 | 3,466 (26.50) | 3,918 (26.94) | |
| ≥35 | 3,076 (23.52) | 3,134 (21.55) | |
| ASA, n (%) |
| ||
| 1 | 514 (3.93) | 480 (3.30) | |
| 2 | 7,510 (57.42) | 8,245 (56.69) | |
| 3 | 4,863 (37.18) | 5,585 (38.40) | |
| 4 | 193 (1.48) | 233 (1.60) | |
| Functional status, n (%) |
| ||
| Independent | 12,932 (98.87) | 14,312 (98.41) | |
| Fully/totally dependent | 148 (1.13) | 231 (1.59) | |
| AAE, n (%) | 0.673 | ||
| No | 10,903 (83.36) | 12,150 (83.55) | |
| Yes | 2,177 (16.64) | 2,393 (16.45) | |
| SAE, n (%) | 0.521 | ||
| No | 12,653 (96.74) | 14,088 (96.87) | |
| Yes | 427 (3.26) | 455 (3.13) | |
| Discharge disposition, n (%) |
| ||
| Home | 11,412 (87.25) | 12,310 (84.65) | |
| Not home | 1,668 (12.75) | 2,233 (15.35) | |
| LOS (d) |
| ||
| Mean ± SD | 2.32 ± 1.65 | 2.35 ± 1.62 | |
| Median (IQR) | 2 (1-3) | 2 (1-3) |
AAE = any adverse event, ASA = American Society of Anesthesiologists, BMI = body mass index, CVA = cerebrovascular accident, DVT = deep vein thrombosis, IQR = interquartile range, LOS = length of stay, OR = operating room, SAE = serious adverse event, THA = total hip arthroplasty, UTI = urinary tract infection
Chi square goodness-of-fit test.
AAE includes UTI, bleeding transfusions, extended length of stay >75th percentile, pneumonia, return to OR within 30 days, wound events (infections and dehiscence), sepsis/septic shock, respiratory events (reintubation and failure to wean), thromboembolic events (DVT and pulmonary emboli), cardiac events (myocardial infarction and cardiac arrest), renal events (renal insufficiency and renal failure), stroke/CVA, and death.
SAE includes pneumonia, return to OR within 30 days, wound events (infections and dehiscence), sepsis/septic shock, respiratory events (reintubation and failure to wean), thromboembolic events (DVT and pulmonary emboli), cardiac events (myocardial infarction and cardiac arrest), renal events (renal insufficiency and renal failure), stroke/CVA, and death.
Significance set at P < 0.05.
TKA Shows Demographic and Discharge Destination Differences When Stratified by Medicare Eligibility
| Variable | <65 (63-64) | ≥65 (65-66) | |
| Total, n (%) | 23,431 (46.34) | 27,128 (53.66) |
|
| Sex, n (%) |
| ||
| Female | 13,927 (59.44) | 16,401 (60.46) | |
| Male | 9,504 (40.56) | 10,727 (39.54) | |
| Race/ethnicity, n (%) |
| ||
| Non-Hispanic White | 15,737 (67.16) | 19,026 (70.13) | |
| Hispanic | 920 (3.93) | 986 (3.63) | |
| Black or African American | 1,781 (7.60) | 1,756 (6.47) | |
| Asian | 499 (2.13) | 564 (2.08) | |
| Other | 4,494 (19.18) | 4,796 (17.68) | |
| BMI (kg/m2), n (%) |
| ||
| <18.5 | 35 (0.15) | 41 (0.15) | |
| 18.5-24 | 1,517 (6.47) | 1,937 (7.14) | |
| 25-29 | 5,439 (23.21) | 6,581 (24.26) | |
| 30-34 | 6,789 (28.97) | 8,122 (29.94) | |
| ≥35 | 9,651 (41.19) | 10,447 (38.51) | |
| ASA, n (%) | 0.997 | ||
| 1 | 491 (2.10) | 565 (2.08) | |
| 2 | 12,002 (51.22) | 13,906 (51.26) | |
| 3 | 10,609 (45.28) | 12,286 (45.29) | |
| 4 | 327 (1.40) | 369 (1.36) | |
| Functional status, n (%) | 0.958 | ||
| Independent | 23,227 (99.13) | 26,893 (99.13) | |
| Partially/totally dependent | 204 (0.87) | 235 (0.87) | |
| AAE, n (%) | 0.091 | ||
| No | 19,645 (83.84) | 22,894 (84.39) | |
| Yes | 3,786 (16.16) | 4,234 (15.61) | |
| SAE, n (%) | 0.420 | ||
| No | 22,676 (96.78) | 26,288 (96.90) | |
| Yes | 755 (3.22) | 840 (3.10) | |
| Discharge disposition, n (%) |
| ||
| Home | 19,803 (84.52) | 22,325 (82.30) | |
| Not home | 3,628 (15.48) | 4,803 (17.70) | |
| LOS (d) | 0.356 | ||
| Mean ± SD | 2.47 ± 1.47 | 2.47 ± 1.45 | |
| Median (IQR) | 2 (2-3) | 2 (2-3) |
AAE = any adverse event, ASA = American Society of Anesthesiologists, BMI = body mass index, CVA = cerebrovascular accident, DVT = deep vein thrombosis, IQR = interquartile range, LOS = length of stay, OR = operating room, SAE = serious adverse event, TKA = total knee arthroplasty, UTI = urinary tract infection
Chi squared goodness of fit test.
Not home includes a skilled care facility, rehab facility, against medical advice, facility that was home, hospice, multilevel senior community, separate acute care, unskilled facility not home, and unknown.
AAE includes UTI, bleeding transfusions, extended length of stay >75th percentile, pneumonia, return to OR within 30 days, wound events (infections and dehiscence), sepsis/septic shock, respiratory events (reintubation and failure to wean), thromboembolic events (DVT and pulmonary emboli), cardiac events (myocardial infarction and cardiac arrest), renal events (renal insufficiency and renal failure), stroke/CVA, and death.
SAE includes pneumonia, return to OR within 30 days, wound events (infections and dehiscence), sepsis/septic shock, respiratory events (reintubation and failure to wean), thromboembolic events (DVT and pulmonary emboli), cardiac events (myocardial infarction and cardiac arrest), renal events (renal insufficiency and renal failure), stroke/CVA, and death.
Significance set at P < 0.05.