Mortality Among Danish Patients with a Hospital Diagnosis of Overweight or Obesity Over a 40-Year Period.

Purpose: Data on long-term mortality among patients with hospital-diagnosed overweight/obesity are limited. Thus, we aim to examine 40-year mortality among patients with hospital-diagnosed overweight/obesity, including cause-specific deaths, secular time trends, and potential effect modification by age, comorbidity, and socioeconomic factors. Patients and
Methods: From national registries, we identified all Danes with a first hospital-based overweight/obesity diagnosis (N=331,185), 1979-2018, and constructed an age- and gender-matched general population comparison cohort (N=1,655,925). We computed mortality rates (MRs) per 1000 person-years and adjusted mortality rate ratios (aMRRs) with 95% confidence intervals (CIs), using Cox regression with adjustment for comorbidities and educational level. We performed stratified analyses on age, comorbidities, and socioeconomic factors.
Results: The overall aMRR was 1.70 (95% CI: 1.68-1.72) for patients with overweight/obesity, mainly due to diabetes and other endocrine diseases (aMRR=2.68 [95% CI: 2.57-2.81]), cardiovascular (aMRR=1.95 [95% CI: 1.91-1.98]), and respiratory diseases (aMRR=1.83 [95% CI: 1.77-1.89]). The 1-10-year aMRR decreased from 2.06 (95% CI: 2.01-2.11) in 1979-1989 to 1.29 (95% CI: 1.26-1.32) in 2000-2009. We found effect modification by age: age 18 to <30 years: aMRR=2.44 (95% CI: 2.24-2.66) vs age ≥70 years: 1.35 (95% CI: 1.33-1.37); comorbidities: baseline comorbidities: aMRR=1.13 (95% CI: 1.10-1.15) vs no comorbidities: aMRR=1.83 (95% CI: 1.80-1.85); and educational level: high educational level: aMRR=1.81 (95% CI: 1.74-1.88) vs low educational level: aMRR=1.70 (95% CI: 1.67-1.72).
Conclusion: Patients with overweight/obesity had a substantially increased long-term mortality, mainly due to diabetes, cardiovascular, and respiratory diseases. The excess mortality decreased during recent decades. Age, comorbidities, and socioeconomic factors modified the association.

Introduction

Obesity prevalence has increased dramatically during recent decades and is a global pandemic.1,2 Obesity is associated with multi-morbidity, diminished quality of life, and increased global health costs.3 General population studies have reported increased mortality among persons with obesity vs persons with normal weight.4–8

The aetiology of obesity and its clinical consequences is complex and multifactorial. Physiological consequences of obesity such as systemic low-grade inflammation, oxidative stress, and endothelial dysfunction9 may contribute to the important associations between obesity and risk of diabetes,10 cardiovascular disease,11–13 several cancers,14–16 infections,17 and neuropsychiatric diseases.18,19 People in lower socioeconomic positions live shorter lives, and they spend more years with disability.20 Socioeconomic factors may most likely modulate the mortality risk in patients with overweight/obesity.21

Short-term studies have indicated a protective effect of obesity on in-hospital mortality in relation to severe illness; the so-called “obesity paradox”,22–25 but a few studies with a median follow-up time of 1.5 to 4 years have shown that the apparent protective effect of obesity may decrease over time.25–27 The clinical implications of these long-term changes in risk remain poorly understood. Attempts to clarify these issues have been hampered by small cohorts, lack of co-morbidity data, and lack of information on causes of death. Such data are needed to understand and potentially improve the clinical course after a hospital diagnosis of obesity. A hospital contact which result in registration of an overweight/obesity discharge diagnosis code by a caregiver indicates that the overweight/obesity status may be of significant importance for the patient’s future health. A hospital contact is thus a window of risk assessment and an opportunity to initiate preventive interventions that may improve patients’ long-term health and reduce their mortality.

We conducted a nationwide hospital-based study to examine overall and cause-specific mortality in a large cohort of patients with an inpatient or outpatient hospital contact leading to registration of an overweight/obesity diagnosis code, compared with a general population age-and gender-matched cohort. We also examined secular time trends and potential effect modification by comorbidities and socioeconomic factors.

Materials and Methods

Study Design, Data Sources, and Setting

This cohort study drew on the entire Danish population, with 8.8 million residents between January 1, 1979 and December 31, 2018. In Denmark, health care services are free and tax supported28 and all health care contacts are registered in the Danish health care registries. Civil registration numbers (unique identifiers encoding sex and birth date) are used to track all medical records for individual patients.29 We included data from The Danish Civil Registration System (CRS),29 The Danish National Patient Registry (DNPR),30 The Danish Register of Causes of Death (DRCD),31 and The Integrated Database for Labour Market Research (IDLMR).32 Further details on data sources are provided in .

Patients with Overweight or Obesity

From the CRS and the DNPR, we identified patients with a first inpatient or outpatient diagnosis code for overweight/obesity recorded at any Danish hospital during 1979–2018 ( and ). We did not include patients with a diagnosis code of overweight/obesity recorded during 1977–1978, to ensure at least a 2-year comorbidity history before the diagnosis. We obtained complete hospital histories for all persons beginning in 1977 and linked the resulting dataset to records in the CRS. For patients with secondary diagnosis codes of overweight/obesity, we tabulated the 25 most common primary diagnosis codes ().

Population Comparison Cohort

We used the CRS and the DNPR to generate a population-based comparison cohort. For each patient with a first overweight/obesity record in the DNPR, we randomly frequency matched five comparison persons from the general population of Denmark, using the CRS linked to the DNPR, which together combine sex, birth date, and a complete hospital discharge history for the entire Danish population. The five comparisons were frequency matched on the date of the corresponding index patient’s first overweight/obesity record, among all general population members with the same sex and year of birth as the index patient. We performed the matching with replacement.33 We defined the hospital contact/matching date for patients with overweight/obesity and persons in the comparison cohort as the index date. People in the comparison cohort were not registered with a hospital diagnosis of overweight/obesity before or at the index date, but they may have had other hospital contacts, and they may be diagnosed with overweight/obesity later in the study period. If a person in the comparison cohort subsequently was diagnosed with overweight/obesity, he or she joined the overweight/obesity cohort.34

Effect Modification

Age, comorbidities, and socio-economic factors may impact mortality risk and modify the association between obesity and mortality.3 We obtained information on age from the CRS. We used the DNPR data to summarize each participant’s (patient with overweight/obesity or comparison) available lifetime comorbidity history, based on the Charlson Comorbidity Index (CCI).35 We grouped participants according to their overall level of comorbidity, defined as a CCI score of 0 (none), 1–2 (moderate), and 3+ (high) ().

We obtained information on the following diseases separately, due to their potential impact on mortality risk: cancer, diabetes, stroke, acute myocardial infarction, and heart failure (). From the IDLMR we obtained information on yearly personal gross income and highest level of education achieved. We divided patients into groups according to low, intermediate, high, or very high income and according to basic education, youth education, or higher education.

Mortality and Causes of Death

We identified the date of death and the underlying cause of death from the DRCD, grouped by ICD-8/ICD-10 diagnosis codes ().

Statistical Analyses

We followed all participants from the index date and until date of death, emigration, or December 31, 2018, whichever came first. We characterized patients with overweight/obesity and persons in the comparison cohort in terms of sex, age categories, and time period of diagnosis. We computed the median age with interquartile range (IQR) at inclusion and median follow-up time for both cohorts. We calculated the absolute mortality risk and the mortality rates (MRs) per 1000 person-years. We used Cox proportional-hazards regression analysis to compute mortality rate ratios (MRRs; specifically, hazard ratios) as measures of relative mortality risk, comparing patients with overweight/obesity to persons in the comparison cohort. In the Cox regression analysis, we dissolved the matching and instead included the matching factors as covariates in the model as the matching factors did not remain balanced over time. In addition to sex, age, and time period, we adjusted for prior diagnoses up to the index date of cancer, diabetes, stroke, acute myocardial infarction, or heart failure, educational level, and income.

To examine for effect modification, we repeated the adjusted MRR (aMRR) analyses, stratified by age (18 to <30, 30 to <40, 40 to <50, 50 to <60, 60 to <70, and ≥70 years), sex (female/male), time period (1979–1989, 1990–1999, 2000–2009, and 2010–2018), baseline CCI score (none, moderate, high), cancer (yes/no), diabetes (yes/no), stroke (yes/no), acute myocardial infarction (yes/no), heart failure (yes/no), education level (basic education/youth education/higher education), income (low/intermediate/high/very high), type of hospital contact (inpatient/outpatient), and type of diagnosis code (primary vs secondary and overweight vs obesity).

For the time periods 1979–1989, 1990–1999, 2000–2009, and 2010–2018 we present the cumulative mortality graphically according to age group. We computed MRs, crude MRR, and aMRRs using Cox proportional-hazards regression analysis for the time periods 0–364 days, 1–10 years, 11–20 years, 21–30 years, 31–40 years, and 0–40 years after the index date. We used log-log plots to test the proportionality of hazards visually and found that the assumptions were fulfilled for each of the follow-up periods.

Finally, we calculated MRs and crude and adjusted MRRs for the most frequent causes of death and compared cause-specific mortality rates in the two cohorts. We tested for secular trends using the Wald χ2 test with a significance level of <0.0001.

We conducted all statistical analyses using SAS version 9.4 (SAS Institute, Cary, NC).

Results

Descriptive Data

In the overweight/obesity cohort (N = 331,185 patients; 2,997,960 person-years; median follow-up time 7.7 years) and the comparison cohort (N = 1,655,925 persons; 16,407,090 person-years; median follow-up time 8.1 years), 75.6% were female and the median age was 45 years (Table 1). More patients in the overweight/obesity cohort vs the comparison cohort had a CCI score of ≥1: 38.1% vs 17.3%, respectively. Frequent comorbidities included diabetes (14.2% vs 2.0%), cancer (5.9% vs 4.1%), and heart failure (4.2% vs 0.8%). Patients with overweight/obesity had a lower educational level than persons in the comparison cohort: basic education: 35.1% vs 26.0%.

Table 1

Characteristics of Patients with Overweight/Obesity and the General Population Cohort, and Mortality Rates and Rate Ratios Overall and by Subgroups

Characteristic		Overweight/Obesity Cohort		Comparison Cohort
	N with Characteristic	% with Characteristic	Mortality Rate (95% Confidence Interval) per 1000 Person-Years	N with Characteristic	% with Characteristic	Mortality rate (95% Confidence Interval) per 1000 Person-Years	Adjusted* Mortality Rate Ratio (95% Confidence Interval)
Total	331,185	100.0	22.81 (22.63–22.98)	1,655,925	100.0	14.93 (14.87–14.99)	1.70 (1.68–1.72)
Female	250,513	75.6	17.41 (17.24–17.58)	1,252,565	75.6	12.53 (12.46–12.59)	1.59 (1.57–1.61)
Male	80,672	24.4	39.49 (39.03–39.94)	403,360	24.4	21.28 (21.15–21.41)	1.89 (1.86–1.92)
Median age, years (IQR)	44.9 (32.8, 61.2)			44.9 (32.8, 61.2)
Age (years)
18-<30	66,526	20.1	1.56 (1.47–1.66)	333,010	20.1	0.52 (0.49–0.55)	2.44 (2.24–2.66)
30-<40	74,652	22.5	3.90 (3.76–4.04)	372,982	22.5	1.40 (1.37–1.44)	2.26 (2.15–2.38)
40-<50	50,529	15.3	12.74 (12.43–13.05)	252,850	15.3	4.85 (4.77–4.93)	2.37 (2.29–2.45)
50-<60	50,911	15.4	26.94 (26.49–27.40)	254,505	15.4	13.50 (13.37–13.63)	2.00 (1.96–2.05)
60-<70	47,548	14.4	50.40 (49.69–51.12)	237,489	14.3	29.31 (29.09–29.53)	1.76 (1.73–1.79)
≥70	41,019	12.4	110.80 (109.45–112.17)	205,089	12.4	75.48 (75.04–75.92)	1.35 (1.33–1.37)
Time period
1979–1989	34,331	10.4	51.49 (50.89–52.10)	171,655	10.4	30.16 (29.99–30.34)	2.10 (2.07–2.13)
1990–1999	26,453	8.0	30.73 (30.21–31.25)	132,265	8.0	17.47 (17.31–17.63)	1.88 (1.83–1.92)
2000–2009	112,523	34.0	14.17 (13.96–14.37)	562,615	34.0	9.04 (8.96–9.11)	1.34 (1.32–1.37)
2010–2018	157,878	47.7	12.00 (11.75–12.26)	789,390	47.7	7.60 (7.51–7.69)	1.24 (1.21–1.27)
Charlson comorbidity index level
None (CCI score =0)	204,961	61.9	10.55 (10.40–10.69)	1,370,540	82.8	12.05 (11.99–12.10)	1.83 (1.80–1.85)
Moderate (CCI score =1–2)	98,137	29.6	38.91 (38.49–39.32)	237,766	14.4	29.85 (29.59–30.10)	1.33 (1.31–1.35)
High (CCI score = 3+)	28,087	8.5	87.79 (86.35–89.25)	47,619	2.9	74.43 (73.37–75.49)	1.13 (1.10–1.15)
Comorbidity at obesity/overweight diagnosis
Cancer
No	311,482	94.1	21.21 (21.04–21.38)	1,587,297	95.9	14.07 (14.01–14.13)	1.73 (1.72–1.75)
Yes	19,703	5.9	63.22 (61.77–64.69)	68,628	4.1	44.60 (43.99–45.21)	1.35 (1.32–1.39)
Diabetes
No	284,110	85.8	18.49 (18.33–18.66)	1,623,523	98.0	14.52 (14.47–14.58)	1.77 (1.75–1.79)
Yes	47,075	14.2	48.64 (47.99–49.31)	32,402	2.0	45.91 (45.01–46.82)	1.11 (1.09–1.14)
Stroke
No	322,121	97.3	21.83 (21.66–22.00)	1,631,895	98.5	14.51 (14.45–14.57)	1.74 (1.72–1.75)
Yes	9064	2.7	72.03 (69.87–74.22)	24,030	1.5	62.06 (60.79–63.35)	1.12 (1.08–1.16)
Acute myocardial infarction
No	317,585	95.9	21.16 (20.99–21.33)	1,633,985	98.7	14.50 (14.44–14.55)	1.72 (1.70–1.74)
Yes	13,600	4.1	67.74 (66.18–69.31)	21,940	1.3	60.10 (58.90–61.32)	1.19 (1.15–1.23)
Heart failure
No	317,191	95.8	20.16 (19.99–20.32)	1,642,008	99.2	14.55 (14.49–14.61)	1.73 (1.71–1.75)
Yes	13,994	4.2	120.05 (117.65–122.47)	13,917	0.8	101.31 (99.01–103.64)	1.16 (1.12–1.20)
Type of overweight/obesity diagnosis code
Primary diagnosis	39,644	12.0	15.47 (15.13–15.81)	198,220	12.0	9.58 (9.47–9.70)	1.81 (1.76–1.86)
Secondary diagnosis	291,541	88.0	24.29 (24.09–24.48)	1,457,705	88.0	15.97 (15.91–16.04)	1.69 (1.67–1.70)
Overweight or obesity
Overweight	65,807	19.9	6.31 (6.08–6.54)	329,035	19.9	5.36 (5.27–5.46)	1.02 (0.97–1.06)
Obesity	85,980	26.0	8.28 (8.04–8.52)	429,900	26.0	5.84 (5.75–5.93)	1.16 (1.12–1.20)
Unspecified overweight/obesity code	179,398	54.2	30.58 (30.34–30.83)	896,990	54.2	18.85 (18.77–18.93)	1.82 (1.80–1.84)
First hospital contact type
Inpatient	145,283	43.9	34.01 (33.72–34.30)	726,415	43.9	20.44 (20.35–20.53)	1.96 (1.94–1.98)
Outpatient	185,902	56.1	11.02 (10.85–11.19)	929,510	56.1	7.91 (7.85–7.98)	1.16 (1.14–1.18)
Income
Low	82,611	24.9	42.92 (42.45–43.38)	413,001	24.9	27.36 (27.20–27.51)	1.70 (1.67–1.72)
Intermediate	95,251	28.8	23.27 (22.95–23.59)	385,095	23.3	17.25 (17.12–17.38)	1.51 (1.48–1.54)
High	88,261	26.7	11.35 (11.12–11.58)	416,354	25.1	8.36 (8.27–8.44)	1.80 (1.75–1.85)
Very high	63,967	19.3	11.08 (10.80–11.36)	434,469	26.2	6.90 (6.82–6.98)	2.04 (1.98–2.11)
Missing	1095	0.3		7006	0.4
Education
Basic education or primary school	116,123	35.1	24.55 (24.27–24.83)	430,906	26.0	16.99 (16.87–17.11)	1.65 (1.63–1.68)
Youth education, high school, or similar education	122,878	37.1	13.19 (12.98–13.41)	629,638	38.0	7.86 (7.79–7.93)	1.70 (1.67–1.74)
Higher education	64,419	19.5	8.38 (8.13–8.64)	455,032	27.5	5.10 (5.03–5.17)	1.81 (1.74–1.88)
Unknown	27,765	8.4	97.98 (96.64–99.33)	140,349	8.5	63.71 (63.30–64.11)	1.69 (1.66–1.72)

Notes: *Adjusted for age, sex, time period, cancer, diabetes, stroke, acute myocardial infarction, heart failure, education level, and income.

In total, 291,541 (88.0%) patients had a secondary diagnosis code of overweight/obesity (), with almost half (145,283; 43.9%) having an inpatient hospital code. We found a large increase in the absolute number of patients with overweight/obesity during our study period, with 157,878 of all patients (47.7%) diagnosed in the final 9 years.

Overall 40-Year Mortality

The absolute mortality risks over the maximum 40 years of follow-up were 75.6% (95% CI: 74.6–76.6%) in the overweight/obesity cohort vs 70.3% (95% CI: 69.8–70.7%) in the comparison cohort ().

The MRs and the MRRs for the overweight/obesity cohort were markedly higher than for the comparison cohort during the entire study period (Table 2). The overall MR was 22.81 (95% CI: 22.63–22.98) per 1000 person-years for the overweight/obesity cohort vs 14.93 (95% CI: 14.87–14.99) per 1000 person-years for the comparison cohort. The overall MRR was 2.22 (95% CI: 2.20–2.24), when adjusting for matching factors only, and 1.70 (95% CI: 1.68–1.72) when adjusting for matching factors, baseline comorbidities, and educational level ().

Table 2

Mortality Rates and Rate Ratios Associated with Overweight/Obesity, by Different Time Periods and Durations of Follow-Up

Time Period	Cohort	Mortality Rate (95% Confidence Interval) per 1000 Person-Years	Crude Mortality Rate Ratio (95% Confidence Interval)	Adjusteda Mortality Rate Ratio (95% Confidence Interval)
1979–2018
Entire period (1979–2018)	Comparison cohort	14.93 (14.87–14.99)	1	1
	Overweight/obesity cohort	22.81 (22.63–22.98)	1.64 (1.62–1.65)	1.70 (1.68–1.72)
Different follow-up periods
1–364 days	Comparison cohort	7.41 (7.27–7.54)	1	1
	Overweight /obesity cohort	24.99 (24.44–25.54)	3.37 (3.28–3.47)	2.40 (2.33–2.48)
1–10 years	Comparison cohort	10.60 (10.53–10.66)	1	1
	Overweight /obesity cohort	18.56 (18.37–18.75)	1.76 (1.74–1.78)	1.54 (1.52–1.57)
11–20 years	Comparison cohort	21.40 (21.25–21.56)	1	1
	Overweight /obesity cohort	30.01 (29.57–30.46)	1.43 (1.41–1.45)	1.75 (1.72–1.79))
21–30 years	Comparison cohort	36.04 (35.69–36.40)	1	1
	Overweight /obesity cohort	40.89 (39.84–41.96)	1.14 (1.11–1.17)	1.84 (1.78–1.90)
31–40 years	Comparison cohort	48.37 (47.55–49.19)	1	1
	Overweight /obesity cohort	46.40 (44.06–48.80)	0.96 (0.91–1.01)	1.68 (1.58–1.78)
1979–1989
Entire period (1979–1989)	Comparison cohort	30.16 (29.99–30.34)	1	1
	Overweight /obesity cohort	51.49 (50.89–52.10)	1.76 (1.74–1.78)	2.10 (2.07–2.13)
Different follow-up periods
1–364 days	Comparison cohort	16.79 (16.18–17.41)	1	1
	Overweight /obesity cohort	84.25 (81.12–87.43)	5.00 (4.74–5.27)	3.45 (3.25–3.66)
1–10 years	Comparison cohort	23.07 (22.81–23.32)	1	1
	Overweight /obesity cohort	52.22 (51.29–53.17)	2.28 (2.23–2.33)	2.06 (2.01–2.11)
11–20 years	Comparison cohort	30.20 (29.88–30.51)	1	1
	Overweight /obesity	49.17 (48.07–50.28)	1.63 (1.59–1.67)	2.17 (2.11–2.24)
21–30 years	Comparison cohort	38.75 (38.32–39.18)	1	1
	Overweight /obesity cohort	44.14 (42.83–45.48)	1.14 (1.10–1.18)	1.92 (1.85–1.99)
31–40 years	Comparison cohort	48.37 (47.55–49.19)	1	1
	Overweight /obesity cohort	46.40 (44.06–48.80)	0.96 (0.91–1.01)	1.68 (1.58–1.78)
1990–1999
Entire period (1990–1999)	Comparison cohort	17.47 (17.31–17.63)	1	1
	Overweight /obesity cohort	30.73 (30.21–31.25)	1.79 (1.76–1.83)	1.88 (1.83–1.92)
Different follow-up periods
1–364 days	Comparison cohort	9.45 (8.93–9.98)	1	1
	Overweight /obesity cohort	40.32 (37.91–42.81)	4.26 (3.92–4.63)	3.05 (2.77–3.36)
1–10 years	Comparison cohort	12.39 (12.19–12.60)	1	1
	Overweight /obesity cohort	29.09 (28.35–29.84)	2.36 (2.29–2.43)	2.07 (1.99–2.14)
11–20 years	Comparison cohort	21.03 (20.75–21.32)	1	1
	Overweight /obesity cohort	30.48 (29.65–31.33)	1.45 (1.41–1.50)	1.70 (1.64–1.76)
21–30 years	Comparison cohort	28.28 (27.67–28.90)	1	1
	Overweight /obesity cohort	33.58 (31.87–35.33)	1.19 (1.12–1.26)	1.64 (1.53–1.75)
2000–2009
Entire period (2000–2009)	Comparison cohort	9.04 (8.96–9.11)	1	1
	Overweight /obesity cohort	14.17 (13.96–14.37)	1.57 (1.55–1.60)	1.34 (1.32–1.37)
Different follow-up periods
1–364 days	Comparison cohort	5.60 (5.40–5.80)	1	1
	Overweight /obesity cohort	17.38 (16.62–18.17)	3.10 (2.93–3.29)	2.18 (2.05–2.32)
1–10 years	Comparison cohort	8.04 (7.96–8.13)	1	1
	Overweight /obesity cohort	12.61 (12.39–12.84)	1.57 (1.53–1.60)	1.29 (1.26–1.32)
11–20 years	Comparison cohort	13.94 (13.74–14.14)	1	1
	Overweight /obesity cohort	18.34 (17.82–18.87)	1.33 (1.29–1.37)	1.29 (1.25–1.34)
2010–2018
Entire period (2010–2018)	Comparison cohort	7.60 (7.51–7.69)	1	1
	Overweight /obesity	12.00 (11.75–12.26)	1.58 (1.54–1.62)	1.24 (1.21–1.27)
Different follow-up periods
1–364 days	Comparison cohort	6.28 (6.10–6.46)	1	1
	Overweight /obesity cohort	15.27 (14.65–15.90)	2.43 (2.31–2.56)	1.72 (1.64–1.82)
1–10 years	Comparison cohort	7.96 (7.85–8.06)	1	1
	Overweight /obesity cohort	11.13 (10.86–11.41)	1.40 (1.36–1.44)	1.12 (1.09–1.16)

Notes: aAdjusted for age, sex, time period, cancer, diabetes, stroke, acute myocardial infarction, heart failure, educational level, and income.

1-Year Mortality

During the first year of follow-up, the absolute mortality risks were 2.5% (95% CI: 2.4–2.5%) in the overweight/obesity cohort vs 0.7% (95% CI: 0.7–0.8%) in the comparison cohort (). The aMRR was high during the first year following an overweight/obesity diagnosis: 2.43 (95% CI: 2.36–2.51) (Table 2). The 1-year aMRR declined for patients with overweight/obesity from the beginning of the study period in 1979–1989 (aMRR = 3.45 [95% CI: 3.25–3.66]) and until 2010–2018 (aMRR = 1.72 [95% CI: 1.64–1.82]) (Table 2, Figure 1).

Figure 1

Mortality in the overweight/obesity cohort and in the comparison cohort. (A) Mortality in the overweight/obesity cohort and in the comparison cohort. Year of index date: 1979–1989. (B) Mortality in the overweight/obesity cohort and in the comparison cohort. Year of index date: 1990–1999. (C) Mortality in the overweight/obesity cohort and in the comparison cohort. Year of index date: 2009–2009. (D) Mortality in the overweight/obesity cohort and in the comparison cohort. Year of index date: 2010–2018.

Relative Mortality Beyond 1 Year and Secular Time Trends

The aMRRs of the overweight/obesity cohort vs the comparison cohort remained elevated during the entire follow-up (1–10 year aMRR = 1.54 [95% CI: 1.52–1.57]; 11–20 year aMRR = 1.75 [95% CI: 1.72–1.79]; 21–30 year aMRR = 1.84 [95% CI: 1.78–1.90]; and 31–40 year aMRR = 1.68 (95% CI: 1.58–1.78]) (Table 2, Figure 1). The longest-term aMRRs represent exclusively patients diagnosed early in our 40-year study period, and thus potentially mix time period of diagnosis effects with follow-up duration effects. When following subcohorts, the 1–10-year aMRRs clearly decreased over time (from 2.06 [95% CI: 2.01–2.11] in 1979–1989 to 1.29 [95% CI: 1.26–1.32] in 2000–2009). P-values for secular time trends were < 0.0001.

Causes of Death

Compared with the general population, patients with obesity/overweight had markedly higher all-time death rates for diabetes and other endocrine diseases (aMRR= 2.68 [95% CI: 2.57–2.81]). The absolute number of deaths and the aMRR were high for cardiovascular diseases: aMRR=1.95 [95% CI: 1.91–1.98], respiratory diseases: aMRR=1.83 [95% CI: 1.77–1.89]; and cancer: aMRR=1.44 [95% CI: 1.41–1.46] (Table 3). The aMRRs were also increased due to skin diseases (aMRR=2.81 [95% CI: 2.21–3.58]), genitourinary diseases (aMRR = 2.34 [95% CI: 2.18–2.52), gastrointestinal diseases (aMRR= 2.14 [95% CI: 2.05–2.23]), and infectious diseases (aMRR=1.59 [95% CI: 1.52–1.66]) (Table 3). Patients with overweight/obesity had an aMRR of 1.28 (95% CI: 1.19–1.36) for death due to accidents, an aMRR of 1.60 (95% CI: 1.44–1.78) for suicide, and an aMRR for death due to psychiatric diseases of 0.90 (95% CI: 0.84–0.95).

Table 3

Mortality Rates and Rate Ratios for Specific Causes of Death Among Patients with Overweight/Obesity and Persons in the General Population Cohort, 1979–2018

Cause of Death	Cohort	No. of Deaths	Mortality Rate (95% Confidence Interval) per 1000 Person-Years	Partially Adjusteda Mortality Rate Ratio (95% Confidence Interval)	Adjustedb Mortality Rate Ratio (95% Confidence Interval)
Infectious diseases	Comparison cohort	12,820	0.78 (0.77–0.79)	1	1
	Overweight /obesity cohort	2953	0.99 (0.95–1.02)	2.07 (1.99–2.16)	1.59 (1.52–1.66)
Cancer	Comparison cohort	66,637	4.06 (4.03–4.09)	1	1
	Overweight /obesity cohort	15,426	5.15 (5.06–5.23)	1.66 (1.64–1.69)	1.44 (1.41–1.46)
Diseases of the blood and hematopoietic system and the immune system	Comparison cohort	1013	0.06 (0.06–0.07)	1	1
	Overweight /obesity cohort	200	0.07 (0.06–0.08)	1.71 (1.46–1.99)	1.35 (1.14–1.60)
Endocrine diseases	Comparison cohort	6275	0.38 (0.37–0.39)	1	1
	Overweight /obesity cohort	6519	2.17 (2.12–2.23)	8.40 (8.11–8.70)	2.68 (2.57–2.81)
Psychiatric diseases	Comparison cohort	11,708	0.71 (0.70–0.73)	1	1
	Overweight /obesity cohort	1398	0.47 (0.44–0.49)	1.00 (0.95–1.06)	0.90 (0.84–0.95)
Neurologic diseases	Comparison cohort	7815	0.48 (0.47–0.49)	1	1
	Overweight /obesity cohort	1088	0.36 (0.34–0.38)	1.08 (1.01–1.15)	1.02 (0.95–1.09)
Cardiovascular diseases	Comparison cohort	79,049	4.82 (4.78–4.85)	1	1
	Overweight /obesity cohort	24,916	8.31 (8.21–8.41)	2.69 (2.66–2.73)	1.95 (1.91–1.98)
Respiratory diseases	Comparison cohort	18,483	1.13 (1.11–1.14)	1	1
	Overweight /obesity cohort	5501	1.83 (1.79–1.88)	2.33 (2.26–2.40)	1.83 (1.77–1.89)
Gastrointestinal and liver diseases	Comparison cohort	10,085	0.61 (0.60–0.63)	1	1
	Overweight /obesity cohort	3570	1.19 (1.15–1.23)	2.64 (2.54–2.75)	2.14 (2.05–2.23)
Skin diseases	Comparison cohort	296	0.02 (0.02–0.02)	1	1
	Overweight /obesity cohort	123	0.04 (0.03–0.05)	3.54 (2.85–4.39)	2.81 (2.21–3.58)
Diseases in bone, muscle and connective tissue	Comparison cohort	1594	0.10 (0.09–0.10)	1	1
	Overweight /obesity cohort	345	0.12 (0.10–0.13)	1.77 (1.57–1.99)	1.58 (1.39–1.79)
Genitourinary disease	Comparison cohort	3750	0.23 (0.22–0.24)	1	1
	Overweight /obesity cohort	1267	0.42 (0.40–0.45)	3.03 (2.84–3.23)	2.34 (2.18–2.52)
Pregnancy- and birth-related complications	Comparison cohort	11	0.00 (0.00–0.00)
	Overweight /obesity cohort	10	0.00 (0.00–0.01)	4.77 (2.02–11.26)	3.92 (1.61–9.55)
Injury, poisoning, and other external causes	Comparison cohort	36	0.00 (0.00–0.00)	1	1
	Overweight /obesity cohort	30	0.01 (0.01–0.01)	5.06 (3.11–8.23)	4.63 (2.70–7.95)
Accidents	Comparison cohort	6868	0.42 (0.41–0.43)	1	1
	Overweight /obesity cohort	1342	0.45 (0.42–0.47)	1.54 (1.45–1.63)	1.28 (1.19–1.36)
Suicide	Comparison cohort	1832	0.11 (0.11–0.12)	1	1
	Overweight /obesity cohort	511	0.17 (0.16–0.19)	1.71 (1.55–1.89)	1.60 (1.44–1.78)
Congenital abnormalities, symptoms and abnormal findings, homicide	Comparison cohort	15,728	0.96 (0.94–0.97)	1	1
	Overweight /obesity cohort	2862	0.95 (0.92–0.99)	1.55 (1.49–1.61)	1.33 (1.27–1.39)

Notes: aAdjusted for matching factors only: age, sex, and time period. bAdjusted for age, sex, time period, cancer, diabetes, stroke, acute myocardial infarction, heart failure, education level, and income.

Stratified Analyses

The impact of overweight/obesity decreased with increasing age: age 18 to <30 years: aMRR=2.44 (95% CI: 2.24–2.66) and ≥70 years; aMRR=1.35 (95% CI: 1.33–1.37) (Table 1). Overweight/obesity had a smaller relative impact on mortality in those with pre-existing comorbidities: CCI score=3+: aMRR: 1.13 (95% CI: 1.10–1.15) vs those without comorbidities: aMRR: 1.83 (95% CI: 1.80–1.85). Findings were similar for diabetes: patients with diabetes: aMRR=1.11 (95% CI: 1.09–1.14) vs patients without diabetes: aMRR=1.77 (95% CI: 1.75–1.79), for cancer; patients with cancer: aMRR=1.73 (95% CI: 1.72–1.75) vs patients without cancer; aMRR=1.36 (95% CI: 1.32–1.40), and stroke: patients with stroke: aMRR=1.74 (95% CI: 1.72–1.75) vs patients without stroke aMRR=1.12 (95% CI: 1.08–1.16) (Table 1). The aMRR was 1.59 (95% CI: 1.57–1.61) women and 1.89 (95% CI: 1.86–1.92) for men, and the aMRR for was 1.96 (95% CI: 1.94–1.98) patients with an inpatient diagnosis code and 1.16 (95% CI: 1.14–1.18) for patients with an outpatient diagnosis code.

The aMRR was higher among patients with obesity (1.16 [95% CI: 1.12–1.20]), than for those with overweight (1.02 [95% CI: 0.97–1.06]).

The aMRR associated with overweight/obesity was 1.81 (95% CI: 1.74–1.88) among patients with a higher education compared to 1.65 (95% CI: 1.63–1.68) among those with basic education (Table 1). Among patients with a very high income, the aMRR was 2.04 (95% CI: 1.98–2.11) vs 1.70 (95% CI: 1.67–1.72) among those with a low income.

Discussion

Principal Findings

In this hospital-based 40-year cohort study, we found that inpatients and outpatients with a hospital diagnosis for overweight/obesity had a 1.7-fold increased relative mortality risk compared with that expected from the general population. Over the past four decades we observed gradual reductions in excess 10-year mortality for patients with overweight/obesity. We showed that findings from general population studies on increased diabetes, cardiovascular disease, and cancer risk associated with overweight/obesity could be extended to a hospital care setting. Other aspects of our findings are novel, including the strong association of overweight/obesity with mortality due to respiratory, genitourinary, and skin diseases. We also provide evidence of a large relative impact of obesity on mortality in people of young age, without pre-existing comorbidities, and with high income and a high level of education.

Overall Mortality Risk Was Elevated, but Declined Over the Last Decades

Although the findings of increased long-term mortality risk associated with hospital-diagnosed overweight/obesity are similar to those of general population studies, direct comparisons are difficult, as comorbidities, lifestyle, and other confounding factors impacting mortality may be more frequent in hospitalized persons.4–8,36 Our hospital-based population is an important subset of the general population, and it is plausible that the same social, clinical, and biological mechanisms mediate the increased long-term mortality in the two populations. Previous hospital-based studies have mainly examined short-term mortality, with conflicting results.22–25,27 We found that mortality risk was increased during the entire follow-up period, including the first year of follow up.

In parallel with rising obesity rates, population-level cardiovascular disease incidence and mortality have decreased over the past decades.37 The decline in mortality associated with overweight/obesity since 1979 may be attributable to earlier and better primary prevention and treatment of the overweight/obesity-related comorbidities the general population.37–40 However, increased longevity may be at the expense of a greater proportion of life lived with comorbidities including cardiovascular disease.41 Since the overweight/obesity hospital coding has improved over time, less severe cases of overweight/obesity with lower mortality risk may have been registered in the latest decades. Furthermore, obesity status may change with higher age and long follow-up time. For these reasons, this encouraging result needs to be interpreted carefully.

Effect Modification by Age, Comorbidities, and Socio-Economic Factors

Our finding of a relatively higher relative mortality associated with overweight/obesity among younger persons is in agreement with previous studies.42,43 Our findings add to the evidence that increasing age and baseline comorbidities dilute the association between overweight/obesity and mortality.2,42,43

The association between adverse socioeconomic factors and increased mortality is well established.44 We found a greater relative impact of overweight/obesity on mortality in people with high income and a high level of education. In patients with high socioeconomic status, other comorbidities may be less frequent, leading to a greater isolated impact of obesity.44 In general, the association between socioeconomic status and obesity has weakened over time with the increasing prevalence of obesity.45

New Aspects of Cause-Specific Mortality Risk

In the absence of broad evidence summarizing cause-specific mortality outcomes after hospital admission for overweight/obesity, we analysed the long-term mortality according to major disease categories. Thus, we provide an analysis of the main causes of death that may be associated with overweight/obesity. For the cause-specific mortality from cardiovascular disease, diabetes, and cancer, our risk estimates were in the same direction and of greater magnitude than those derived from previous general population studies.4–8 Our results provide new evidence of hospital-diagnosed overweight/obesity as a harbinger of mortality due to infectious diseases,46–49 respiratory diseases,5,50–52 genitourinary diseases,53 trauma,54,55 and skin diseases,47,56 which have been inconsistently reported in the previous literature.

A large body of research has identified a bidirectional association between obesity and mental disorders,18,57–60 possibly following from inflammation, stigmatization, and adverse lifestyle and self-care, or side effects of antipsychotic drugs.18,61–63 We found no increased mortality due to psychiatric diseases, but our results support an association between overweight/obesity and suicide risk.62,63

Possible Biological Mechanisms

Several interacting factors might explain the increased mortality risk. Overweight/obesity exerts adverse impacts on systemic low-grade inflammation, oxidative stress, insulin resistance, lipid profile, and endothelial dysfunction secondary to adipose tissue-derived pro-inflammatory mediators.9 This leads to a greater risk of diabetes, hypertension, cardiovascular disease, and site-specific cancers. These above-mentioned factors may also, together with decreased lung function, increase susceptibility to infections and their severity.9

Obesity-associated restrictive ventilation and decreased residual volumes, in addition to inflammation, may exacerbate respiratory diseases.64,65 This may outweigh the potentially protective effect of a lower smoking prevalence in patients with overweight/obesity.47 Diagnostic delay and sub-optimal treatment of these comorbidities may still occur in patients with overweight/obesity, due to stigmatization,66 social isolation,67 and related mental disorders.18

Methodological Considerations

The accuracy of our findings depends on the data quality, and our study has several limitations in addition to its strengths. A main limitation is its reliance on overweight/obesity diagnosis codes with no information on exact Body Mass Index (BMI) values. Whereas the completeness of overweight/obesity coding in the DNPR is low: 11% of patients with a BMI ≥25 kg/m2 measured in hospital may receive an overweight/obesity diagnosis code, the positive predictive value of an overweight/obesity diagnosis was 88%.68 The low likelihood of being assigned an overweight/obesity code despite elevated BMI may raise a concern of selection bias. For example, women may more likely be assigned an overweight/obesity code than men (76% of our patients were female). If women had a higher likelihood of having even mild cases of overweight/obesity registered, eg according to the Danish pregnancy care program where routine BMI screening is mandatory,69 while predominantly the more severe cases of overweight/obesity were registered and coded for men, this may have contributed to the aMRR from overweight/obesity being lower in women than men.

Similar mechanisms may have biased the observed aMRRs for overweight/obesity diagnoses downwards in the most recent years (possibly due to increased completeness in the registration of milder cases) versus earlier study years. Furthermore, elderly patients with comorbidity may have a higher likelihood of being assigned a code for mild overweight/obesity, due to their frequent health care encounters. It is possible that predominantly more severe cases of overweight/obesity were registered in young people with otherwise little comorbidity. Such a bias may have contributed to the overweight/obesity aMRRs being lower in older persons with comorbidity than in younger people without comorbidity.

Unfortunately, our registry data did not allow us to further examine the exact BMI associated with overweight/obesity diagnoses. However, we made extensive adjustment for pre-existing comorbidities and type of hospital contact or diagnosis code, when comparing any associations between overweight/obesity and mortality. If for example more severe cases of overweight/obesity were registered for men than for women due to differential coding, men with overweight/obesity would also appear more comorbid on average, and these differences would then be adjusted for in our mortality analyses.

The most commonly used overweight/obesity ICD diagnosis codes were unspecific codes (ie ICD-10 E660 Obesity due to excess calories, or E669 Obesity not specified elsewhere), and thus data on the exact degree and clinical severity of obesity was unfortunately unavailable. Moreover, onset of overweight/obesity likely occurs many years before a hospital contact and thus prevalent and incident cases may be mixed, and left truncation may be a concern.70 Our risk estimates may be conservative, due to both the code’s low sensitivity and the increasing prevalence of overweight and obesity over time in Denmark’s general population, with recent survey data suggesting that 34% are overweight and 17% are obese.71

Finally, all deaths are registered in the DRCD, as a person cannot be declared dead unless a diagnosis code is provided and reported to the registry.31 However, the diagnosis code is assigned by a physician who might not have known the patient’s medical history thoroughly.

Conclusion

Our study raises the need to rethink and revise the clinical handling of obesity, as societal prevention of obesity and its complications is fundamental. A hospital contact is a potential window of opportunity to initiate clinically preventive interventions like treatment of hypertension, hypercholesterolemia, and diabetes, and lifestyle changes.72 Taking these actions would reduce the burden of obesity. Socioeconomic factors may be treated as a target for local and global health strategies, with important implications for mortality.

Importantly, excess mortality declined during the 40-year study period, providing evidence that the prevention and treatment of obesity-related comorbidities are effective and should be extended.