Nicholas J Robert1, Janet L Espirito2, Liwei Chen3, Esmond Nwokeji4, Mandar Karhade5, Makenzi Evangelist6, Alexander Spira7, Marcus Neubauer8, Susie Bullock9, Jennifer Walberg10, Steven K Cheng11, Robert L Coleman12. 1. Ontada, 6555 State Highway 161, Irving, TX 75039, USA. Electronic address: Nicholas.RobertMD@McKesson.com. 2. Ontada, 6555 State Highway 161, Irving, TX 75039, USA. Electronic address: Janet.Espirito@McKesson.com. 3. Ontada, 6555 State Highway 161, Irving, TX 75039, USA. Electronic address: Liwei.Chen@McKesson.com. 4. Ontada, 6555 State Highway 161, Irving, TX 75039, USA. Electronic address: nwokeji@gmail.com. 5. Ontada, 6555 State Highway 161, Irving, TX 75039, USA. Electronic address: Mandar.Karhade@McKesson.com. 6. New York Oncology Hematology, 400 Patroon Creek Blvd Suite 1, Albany, NY 12206, USA; US Oncology Research, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA. Electronic address: makenzi.evangelist@usoncology.com. 7. US Oncology Research, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA; Virginia Cancer Specialists, Fairfax, VA 22031, USA. Electronic address: Alexander.Spira@USOncology.com. 8. US Oncology Research, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA; The US Oncology Network, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA. Electronic address: Marcus.Neubauer@McKesson.com. 9. US Oncology Research, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA. Electronic address: Susie.Bullock@McKesson.com. 10. US Oncology Research, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA. Electronic address: Jennifer.Walberg@McKesson.com. 11. The US Oncology Network, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA. Electronic address: Steven.Cheng@McKesson.com. 12. US Oncology Research, 10101 Woodloch Forest Dr, The Woodlands, TX 77380, USA. Electronic address: Robert.Coleman@McKesson.com.
Abstract
OBJECTIVES: The MYLUNG (Molecularly Informed Lung Cancer Treatment in a Community Cancer Network) consortium pragmatic study assessed real-world biomarker testing rates and turnaround times within a large community-based oncology network. MATERIALS AND METHODS: This retrospective observational chart review study investigated patients with mNSCLC initiating first-line (1L) systemic therapy between 01-April-2018 and 31-March-2020. Biomarker testing rates and timing relative to 1L therapy for EGFR, ALK, ROS1, BRAF, and PD-L1 were assessed, including use of next-generation sequencing (NGS). RESULTS: Among 3474 adults: 74% had adenocarcinoma and 76% had a documented ECOG performance status of 0 or 1. Ninety percent had testing for at least one biomarker, and 46% received all 5 biomarker tests. Changes in testing rates from 2018 to 2020 were 71% to 71% for EGFR, 71% to 70% for ALK, 69% to 67% for ROS1, 51% to 59% for BRAF, 82% to 84% for PD-L1, and 42% to 49% for all 5 biomarkers. NGS testing increased from 33% to 45% (p < 0.0001). Median time from mNSCLC diagnosis to 1L therapy was 35 days. Median turnaround times from biomarker testing orders to results ranged from 10 to 15 days for the individual biomarkers and 18 days for NGS. CONCLUSION: In this real-world study, while most patients received at least one biomarker test prior to 1L, <50% received all 5 tests. NGS testing also occurred in < 50% of patients but appeared to increase over time. The next phase of MYLUNG will evaluate contemporary ordering practices and turnaround times prospectively.
OBJECTIVES: The MYLUNG (Molecularly Informed Lung Cancer Treatment in a Community Cancer Network) consortium pragmatic study assessed real-world biomarker testing rates and turnaround times within a large community-based oncology network. MATERIALS AND METHODS: This retrospective observational chart review study investigated patients with mNSCLC initiating first-line (1L) systemic therapy between 01-April-2018 and 31-March-2020. Biomarker testing rates and timing relative to 1L therapy for EGFR, ALK, ROS1, BRAF, and PD-L1 were assessed, including use of next-generation sequencing (NGS). RESULTS: Among 3474 adults: 74% had adenocarcinoma and 76% had a documented ECOG performance status of 0 or 1. Ninety percent had testing for at least one biomarker, and 46% received all 5 biomarker tests. Changes in testing rates from 2018 to 2020 were 71% to 71% for EGFR, 71% to 70% for ALK, 69% to 67% for ROS1, 51% to 59% for BRAF, 82% to 84% for PD-L1, and 42% to 49% for all 5 biomarkers. NGS testing increased from 33% to 45% (p < 0.0001). Median time from mNSCLC diagnosis to 1L therapy was 35 days. Median turnaround times from biomarker testing orders to results ranged from 10 to 15 days for the individual biomarkers and 18 days for NGS. CONCLUSION: In this real-world study, while most patients received at least one biomarker test prior to 1L, <50% received all 5 tests. NGS testing also occurred in < 50% of patients but appeared to increase over time. The next phase of MYLUNG will evaluate contemporary ordering practices and turnaround times prospectively.
Authors: Aline F Fares; Pedro H Martinez; Pedro H Farina; Isaac Bicalho de Souza; Daniel V Araújo; Narayana S Paiva; Ligia F Orlando; Tatiana Elias Colombo; Eldsamira Mascarenhas; Ana Caroline Z Gelatti; Clarissa Baldotto; Mauro Zukin; Luiz Henrique Araujo; Clarissa Mathias; Gustavo Werutsky; Gilberto de Castro; Vladmir C Cordeiro de Lima Journal: JTO Clin Res Rep Date: 2022-08-30
Authors: Miguel Garcia-Pardo; Kasia Czarnecka; Jennifer H Law; Alexandra Salvarrey; Roxanne Fernandes; Jason Fan; Lucy Corke; Thomas K Waddell; Kazuhiro Yasufuku; Laura L Donahoe; Andrew Pierre; Lisa W Le; Noor Ghumman; Geoffrey Liu; Frances A Shepherd; Penelope Bradbury; Adrian Sacher; Tracy Stockley; Prodipto Pal; Patrik Rogalla; Ming Sound Tsao; Natasha B Leighl Journal: Ther Adv Med Oncol Date: 2022-09-20 Impact factor: 5.485