Radiation-chemotherapy interactions.

The design of radiobiological experiments to study radiation-chemotherapy interactions in tumors and normal tissues is critically reviewed. It is suggested that such experiments should not be designed in such a way as to optimize the treatment strategy for the respective animal model, but to study the influence of one modality on the effectiveness of the other modality with regard to one specific endpoint at a time and its dependence on dose and timing, preferentially in multifraction experiments.