Literature DB >> 35308698

Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation.

Abdullahi E Mahgoub1,2, Dominic Awuah1,2, MurtazaShabbir Hussain1,2, Smit Deliwala1,2, Ghassan Bachuwa1,2, Mariam Younas3,2.   

Abstract

A 79-year-old man suddenly developed right lower extremity (RLE) pain and swelling a few days after receiving his 1st dose of the mRNA-1273 COVID-19 vaccine. Despite this, he proceeded to receive the 2nd dose of his mRNA-1273 COVID-19 vaccine. Investigations confirmed extensive acute deep venous thrombosis and a concurrent acute pulmonary embolism. Therapeutic anticoagulation was initiated and he was eventually discharged home on supplemental oxygen. The overall benefits of the vaccine in curbing severe disease overwhelmingly outweigh the handful of cases of reported adverse events. To our knowledge, this is one of the first few cases of provoked venous thrombosis after receiving the mRNA-1273 COVID-19 vaccine during the pharmacovigilance period.
Copyright © 2022, Mahgoub et al.

Entities:  

Keywords:  covid vaccines; covid-19; mrna-1273 vaccine; vaccine induced thrombosis; venous thromboembolism

Year:  2022        PMID： 35308698      PMCID： PMC8923564          DOI： 10.7759/cureus.22179

Source DB:  PubMed          Journal:  Cureus        ISSN： 2168-8184


  15 in total

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Authors:  F J I Fowkes; J F Price; F G R Fowkes
Journal:  Eur J Vasc Endovasc Surg       Date:  2003-01       Impact factor: 7.069

2.  Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.

Authors:  Julia Hippisley-Cox; Martina Patone; Xue W Mei; Defne Saatci; Sharon Dixon; Kamlesh Khunti; Francesco Zaccardi; Peter Watkinson; Manu Shankar-Hari; James Doidge; David A Harrison; Simon J Griffin; Aziz Sheikh; Carol A C Coupland
Journal:  BMJ       Date:  2021-08-26

3.  Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine - United States, December 14-23, 2020.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2021-01-15       Impact factor: 17.586

4.  Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study.

Authors:  Anton Pottegård; Lars Christian Lund; Øystein Karlstad; Jesper Dahl; Morten Andersen; Jesper Hallas; Øjvind Lidegaard; German Tapia; Hanne Løvdal Gulseth; Paz Lopez-Doriga Ruiz; Sara Viksmoen Watle; Anders Pretzmann Mikkelsen; Lars Pedersen; Henrik Toft Sørensen; Reimar Wernich Thomsen; Anders Hviid
Journal:  BMJ       Date:  2021-05-05

Review 5.  COVID-19 fatality rates in hospitalized patients: systematic review and meta-analysis.

Authors:  Ana Macedo; Nilza Gonçalves; Cláudia Febra
Journal:  Ann Epidemiol       Date:  2021-03-02       Impact factor: 3.797

Review 6.  Vaccine-induced immune thrombotic thrombocytopenia.

Authors:  Frederikus A Klok; Menaka Pai; Menno V Huisman; Michael Makris
Journal:  Lancet Haematol       Date:  2021-11-11       Impact factor: 18.959

7.  Thromboembolic events in younger women exposed to Pfizer-BioNTech or Moderna COVID-19 vaccines.

Authors:  Maurizio Sessa; Kristian Kragholm; Anders Hviid; Morten Andersen
Journal:  Expert Opin Drug Saf       Date:  2021-07-15       Impact factor: 4.250

8.  Post-SARS-CoV-2-vaccination cerebral venous sinus thrombosis: an analysis of cases notified to the European Medicines Agency.

Authors:  Katarzyna Krzywicka; Mirjam R Heldner; Mayte Sánchez van Kammen; Thijs van Haaps; Sini Hiltunen; Suzanne M Silvis; Marcel Levi; Johanna A Kremer Hovinga; Katarina Jood; Erik Lindgren; Turgut Tatlisumak; Jukka Putaala; Diana Aguiar de Sousa; Saskia Middeldorp; Marcel Arnold; Jonathan M Coutinho; José M Ferro
Journal:  Eur J Neurol       Date:  2021-08-04       Impact factor: 6.288

9.  Marked factor V activity elevation in severe COVID-19 is associated with venous thromboembolism.

Authors:  Jonathan A Stefely; Bianca B Christensen; Tasos Gogakos; Jensyn K Cone Sullivan; Gabriella G Montgomery; John P Barranco; Elizabeth M Van Cott
Journal:  Am J Hematol       Date:  2020-09-18       Impact factor: 13.265
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  2 in total

Review 1.  Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns.

Authors:  Dimitra S Mouliou; Efthimios Dardiotis
Journal:  Diagnostics (Basel)       Date:  2022-06-26

2.  Multiple sites of thrombosis without thrombocytopenia after a second dose of Pfizer-BioNTech COVID-19 vaccine.

Authors:  Roberto Scendoni; Cristina Petrelli; Mauro Giustozzi; Francesco O Logullo
Journal:  Int J Immunopathol Pharmacol       Date:  2022 Jan-Dec       Impact factor: 3.298
  2 in total

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