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Literature DB >> 3530801

Stable isotopes of lithium: dissimilar biochemical and behavioral effects.

K Lieberman, G J Alexander, J A Sechzer.

Abstract

Lithium, which is used routinely in the treatment of mania, is composed of two stable isotopes, lithium-7 (92.58%) and lithium-6 (7.42%). Usually there is minimal physiological or biochemical differentiation between isotopes of an element, but lithium is an exception. Data derived from a variety of biochemical and behavioral experiments are reviewed to support this idea. Additionally, the clinical implications of this work are presented.

Entities: Chemical Disease

Mesh：

Substances：
Isotopes
Lithium

Year: 1986 PMID： 3530801 DOI： 10.1007/bf01940701

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

13 in total

1. The international register of lithium babies.

Authors: M R Weinstein
Journal: Drug Inf J Date: 1976 Apr-Sep

2. Detection of stable isotopes of lithium or boron with the help of A (n,alpha) nuclear reaction. Application to the use of 6Li as a tracer for unidirectional flux measurements and to the microlocalization of lithium in animal histologic preparations.

Authors: M Thellier; T Stelz; J C Wissocq
Journal: Biochim Biophys Acta Date: 1976-07-21

3. Lithium-6 stable isotope determination by atomic absorption spectroscopy and its application to pharmacokinetic studies in man.

Authors: N J Birch; D Robinson; R A Inie; R P Hullin
Journal: J Pharm Pharmacol Date: 1978-11 Impact factor: 3.765

Stable isotopes of lithium: dissimilar biochemical and behavioral effects.

1. The international register of lithium babies.

2. Detection of stable isotopes of lithium or boron with the help of A (n,alpha) nuclear reaction. Application to the use of 6Li as a tracer for unidirectional flux measurements and to the microlocalization of lithium in animal histologic preparations.

3. Lithium-6 stable isotope determination by atomic absorption spectroscopy and its application to pharmacokinetic studies in man.

4. Effect of lithium on rearing activity in rats.

5. The effect of prolonged lithium administration on activity, reactivity, and endurance in the rat.

6. Differential lethality of lithium isotopes in mice.

7. Characteristics of the uptake of lithium isotopes into erythrocytes.

8. Dissimilar effects of lithium isotopes on motility in rats.

9. What happened later to the lithium babies? A follow-up study of children born without malformations.

10. Differential uptake of lithium isotopes by rat cerebral cortex and its effect on inositol phosphate metabolism.