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Literature DB >> 35306622

Multiple roles of m⁶A methylation in epithelial-mesenchymal transition.

Xueru Zhao^1,2,3,4, Xue Li^1,2,3,4, Xiaohua Li^5,6,7,8.

Abstract

Epithelial-mesenchymal transition (EMT) plays an important role in migration and invasion of cancer cell and the development of tissue fibrosis diseases. N6-methyladenosine (m6A) is the most extensive type of RNA methylation and has aroused extensive interest in recent years. However, m6A methylation seems to play different roles in different cancer cells and tissue fibrotic diseases. To determine the function of m6A methylation in EMT, we summarized the molecular mechanism of EMT and recent progress in the regulation of EMT by m6A methylation, suggesting that m6A methylation targets EMT program by affecting the expression of transcription factors, EMT markers, long noncoding RNA and EMT-associated signaling pathways, which provides more possibilities for early diagnosis and treatment.

Entities: Chemical

Keywords: Epithelial–mesenchymal transition; Mechanism; RNA modification; m6A methylation

Mesh：

Substances：

Year: 2022 PMID： 35306622 DOI： 10.1007/s11033-022-07368-3

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.742

85 in total

Review 1. Transforming growth factor-β signaling: Tumorigenesis and targeting for cancer therapy.

Authors: Amirhossein Ahmadi; Masoud Najafi; Bagher Farhood; Keywan Mortezaee
Journal: J Cell Physiol Date: 2018-12-07 Impact factor: 6.384

Review 2. The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer.

Authors: Xue Chen; Ann M Bode; Zigang Dong; Ya Cao
Journal: FASEB J Date: 2016-06-08 Impact factor: 5.191

Review 3. An overview of epithelio-mesenchymal transformation.

Authors: E D Hay
Journal: Acta Anat (Basel) Date: 1995

Review 4. Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement.

Authors: Rashmi Bharti; Goutam Dey; Mahitosh Mandal
Journal: Cancer Lett Date: 2016-03-02 Impact factor: 8.679

Review 5. The basics of epithelial-mesenchymal transition.

Authors: Raghu Kalluri; Robert A Weinberg
Journal: J Clin Invest Date: 2009-06 Impact factor: 14.808

6. IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer.

Authors: Chia-Huei Lee; Jeffrey Shu-Ming Chang; Shih-Han Syu; Thian-Sze Wong; Jimmy Yu-Wai Chan; Ya-Chu Tang; Zhi-Ping Yang; Wen-Chan Yang; Chiung-Tong Chen; Shao-Chun Lu; Pei-Hua Tang; Tzu-Ching Yang; Pei-Yi Chu; Jenn-Ren Hsiao; Ko-Jiunn Liu
Journal: J Cell Physiol Date: 2015-04 Impact factor: 6.384

1. N⁶-methyladenosine (m⁶A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner.

Authors: Hao Shen; Keliang Xie; Miaomiao Li; Qianyu Yang; Xiaoye Wang
Journal: Cell Death Discov Date: 2022-07-15

1 in total

Multiple roles of m⁶A methylation in epithelial-mesenchymal transition.

Review 1. Transforming growth factor-β signaling: Tumorigenesis and targeting for cancer therapy.

Review 2. The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer.

Review 3. An overview of epithelio-mesenchymal transformation.

Review 4. Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement.

Review 5. The basics of epithelial-mesenchymal transition.

6. IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer.

7. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.

Review 8. Mesenchymal-epithelial transition in development and reprogramming.

Review 9. The RNA modification landscape in human disease.

10. Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence.

1. N⁶-methyladenosine (m⁶A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner.

Multiple roles of m6A methylation in epithelial-mesenchymal transition.

Review 1. Transforming growth factor-β signaling: Tumorigenesis and targeting for cancer therapy.

Review 2. The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer.

Review 3. An overview of epithelio-mesenchymal transformation.

Review 4. Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement.

Review 5. The basics of epithelial-mesenchymal transition.

6. IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer.

7. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.

Review 8. Mesenchymal-epithelial transition in development and reprogramming.

Review 9. The RNA modification landscape in human disease.

10. Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence.

1. N6-methyladenosine (m6A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner.

Multiple roles of m⁶A methylation in epithelial-mesenchymal transition.

1. N⁶-methyladenosine (m⁶A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner.