Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report.

BACKGROUND: Breast cancer infrequently metastasizes to the sternum as solitary metastasis. We experienced successful treatment with proton beam therapy for a case of sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of oligometastatic sternal metastasis with limited tolerance of normal tissue due to previous photon irradiation. CASE
PRESENTATION: A 40-year-old Japanese female presented with lumpiness in her left breast. The patient was diagnosed with breast cancer (cT1N0M0, cStage IA) and underwent partial mastectomy with axillary lymph node dissection. After the mastectomy, the patient received radiation therapy with 50 Gy in 25 fractions for initial irradiation of the left breast. After the initial irradiation of 50 Gy, the patient received 10 Gy in five fractions of a sequential boost for the tumor bed to a total dose of 60 Gy. Although the patient was administered tamoxifen after radiation therapy, solitary sternal metastasis occurred 6 months after radiation therapy. She refused chemotherapy and requested proton beam therapy for her sternal metastasis. The daily proton beam therapy fractions were 2.5 relative biological effectiveness, receiving a total dose of 70 Gy relative biological effectiveness. An acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. occurred during proton beam therapy, but there was no acute or late complication of more than grade 3. At 3 years after proton beam therapy, the patient remains in complete remission without surgery or chemotherapy. DISCUSSION AND
CONCLUSION: Proton beam therapy for solitary sternal metastasis of breast cancer is considered to be a therapeutic option.

Background

Bone metastasis of breast cancer generally tends to be multiple. However, breast cancer rarely metastasizes to the sternum as solitary metastasis [1]. Management of metastatic breast cancer (MBC) is based on systemic treatment, while the role of local therapy remains controversial.

Proton beam therapy (PBT) is effective because protons have excellent dose localization according to the Bragg peak compared with photons and are biologically equivalent to conventional X-ray treatment for cancer [2-5]. In general, bone metastases are multiple metastases and are not an indication for PBT. We herein report the achievement of successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of oligometastatic sternal metastasis with limited tolerance of normal tissue due to previous photon irradiation.

Case presentation

One year before presentation to our hospital, a 40-year-old Japanese female presented to another hospital with lumpiness in her left breast. The patient had no medical history or family history of breast or ovary cancer. There was no history of drinking or smoking. At the previous hospital, a core needle biopsy revealed invasive ductal carcinoma, estrogen receptor-positive, progesterone receptor-positive, and human epidermal growth factor receptor 2-negative with a Ki-67 index of 23%. On the basis of the examination results, the patient was diagnosed with early breast cancer (cT1N0M0, cStage I) and underwent partial mastectomy with axillary lymph node dissection. After the mastectomy, the patient received radiation therapy (RT) with 50 Gray (Gy) in 25 fractions as initial irradiation for the left breast. After the initial irradiation of 50 Gy, she received 10 Gy in five fractions of a sequential boost for the tumor bed to a total dose of 60 Gy (Fig. 1). Tamoxifen was administered after RT.

Fig. 1

Dose distribution of radiation therapy. The left breast after partial mastectomy was treated with 50 Gy

At 6 months after RT, she presented with a dull pain in her chest wall. Positron emission tomography–computed tomography (PET–CT) revealed uptake of 18F-2-fluoro-2-deoxy-d-glucose (FDG) in the sternum [maximum standardized uptake value (SUVmax) of 4.5] (Fig. 2). Because the patient had a history of breast cancer and FDG-PET results showed a low possibility of malignant disease other than breast cancer, biopsy examination was omitted. The diagnosis was sternal metastasis of breast cancer. The patient had an Eastern Cooperative Oncology Group Performance Score of 1.

Fig. 2

Positron emission tomography–CT revealed uptake of 18F-2-fluoro-2-deoxy-d-glucose in the sternum (maximum standardized uptake value of 4.5)

Although the patient was recommended chemotherapy and RT for bone metastasis of the sternum, she refused to receive chemotherapy and RT owing to concerns about damage caused by these therapies. She and her family requested PBT for her bone metastasis of the sternum. Treatment with the aromatase inhibitor and luteinizing-hormone-releasing hormone agonists was also started at the previous hospital.

The patient was informed of the option of receiving PBT as an alternative to RT. It was difficult to use definitive RT of more than 60 Gy for the metastasis because the sternal metastasis was located close to the initial field of RT. We also considered stereotactic radiotherapy or volumetric modulated arc therapy for her bone metastasis. However, we did not select these therapies because of the increased risk of radiation-induced cardiotoxicity by X-ray treatment.

We gave the patient an explanation about late complications after PBT. She agreed to receive PBT in favor of tumor control despite late complications. The PBT system at our institute (Proton beam system, Mitsubishi, Tokyo, Japan) uses synchrotron and scattering methods. The gross tumor volume (GTV) included the bone metastasis of the sternum. The clinical target volume (CTV) was defined as GTV plus 0.5-cm margins and the whole sternum. We determined the CTV on the basis of the margins that surgery is performed on a solitary sternal metastasis. The planning target volume (PTV) was CTV plus 0.5-cm margins. The daily PBT fractions were 2.5 relative biological effectiveness (RBE) for PTV that received a total dose of 70 Gy RBE in 28 fractions. The overall treatment duration was 41 days. After initial irradiation of 50 Gy RBE in 20 fractions (Fig. 3), the patient received 20 Gy RBE in 8 fractions of a sequential boost for the sternal metastasis alone to a total dose of 70 Gy RBE (Fig. 4). The dosimetric comparison between PBT and photon beam therapy is shown in Table 1 and Figure 5.

Fig. 3

Dose distribution of initial proton beam therapy (PBT) in an axial field (a) and a coronal field (b). The daily PBT fractions were 2.5 relative biological effectiveness (RBE) for PTV, receiving a total dose of 50 Gy RBE. The gross tumor volume was 16.21 cm3. The clinical target volume was 60.44 cm3, and the planning target volume was 147.31 cm3

Fig. 4

Dose distribution of boost proton beam therapy in an axial field (a) and a coronal field (b). The patient received 20 Gy relative biological effectiveness (RBE) in five fractions of a sequential boost for the sternal metastasis alone to a total dose of 70 Gy RBE. The gross tumor volume was 16.21 cm3. The clinical target volume was 29.89 cm3, and the planning target volume was 70.96 cm3

Table 1

Dosimetric comparison between proton beam therapy and photon beam therapy

OAR	DVH parameter	PBT	IMRT (VMAT)
Lung	V20 (%)	2.02	21.98
	V5 (%)	3.91	66.6
	Mean dose (Gy)	1.15	12.3
Heart	V40 (%)	4.39	7.8
	V30 (%)	5.75	19.7
	V20 (%)	7.33	44.1
	Mean dose (Gy)	3.92	18.65
Esophagus	Maximum dose (Gy)	0.84	32.5
Spinal cord	Maximum dose (Gy)	0	18.643

DVH dose–volume histogram; IMRT intensity-modulated radiation therapy; OAR organ at risk; PBT proton beam therapy; VMAT volumetric modulated arc therapy

Fig. 5

Dose distribution for proton beam therapy (a) and photon beam therapy (b). Photon beam therapy shows a dose distribution of 70 Gy in 28 fractions by intensity-modulated radiation therapy (IMRT). With the IMRT, a high-dose area was seen on the heart (white arrow), and a low-dose area was spread to the bilateral lungs (yellow arrow)

The acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. occurred during PBT (Fig. 6), but there was no acute or late complication higher than grade 3. Four months after PBT, the patient became aware of pain near the radiation field after exercising.

Fig. 6

Macroscopic findings of the chest on the final day of proton beam therapy. The acute side effect in skin was grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0

Although the symptoms resolved in about a month, the hormone therapy was continued. At 3 years after PBT, the patient remains in complete remission without surgery or chemotherapy (Fig. 7).

Fig. 7

Positron emission tomography 3 years after proton beam therapy (PBT). PBT resulted in the disappearance of high uptake of fluorodeoxyglucose in the sternum

The timeline for the present case is shown in Fig. 8.

Fig. 8

Timeline for intervention and clinical outcome

Discussion

Metastatic breast cancer is difficult to cure. The main treatment for MBC is systemic therapy, and the role of local therapy remains controversial. There are rare cases where only a few metastases occur in MBC. Bone metastases are the most common metastases of breast cancer. Patients with solitary bone metastasis account for approximately half of all breast cancer patients [6]. Sternal metastasis from breast cancer can occur as a result of direct spread from involved intramammary nodes or isolated intramanubrial bone metastases [7]. Kozumi et al. reported that the incidence of metastasis in the sternum was 34% in patients with solitary bone metastasis [1]. Solitary sternal metastasis can remain solitary and confined to the sternum for a long time because the blood in the sternum lacks communication to the paravertebral venous plexus flow [8, 9].

Cancer status with fewer than five metastatic or recurrent lesions and with controlled primary lesions can be considered as “oligo-metastases” or “oligo-recurrence” [10]. The term “oligo-metastases” was first reported in 1995 by Hellman and Weichselbaum [11]. Several retrospective studies showed that patients with oligo-metastases who received local therapy had a good prognosis. The overall survival rate in those patients was 82% at 10 years and 53% at 20 years [12]. It is reasonable to consider that our case was oligo-recurrence of a solitary sternal metastasis with a good prognosis.

In current guidelines for and reports on palliative radiation therapy for patients with breast cancer, a single fraction of 8–10 Gy or 20 Gy in 4–5 fractions is recommended for patients with poor performance status (PS), and 30 Gy in 10 fractions or 50 Gy in 25 fractions is recommended for patients with good PS [13-15].

It is difficult to cure bone metastases with radiation therapy at doses less than 50 Gy. Li et al. reported that a single fraction of RT with 20 Gy for sternal metastases in oligometastatic breast cancer was beneficial for local disease control. In their study, in-field control was achieved in nine of ten patients at a median follow-up of 32 months; however, they also reported that seven of the ten patients had distant relapse after RT, and the median time to distant relapse was 11 months. Kamiyoshihara et al. also reported a severe complication after radiation therapy for sternal metastasis. Although there was no detailed information about the radiation therapy in their report, aortic hemorrhage due to mediastinal infection occurred in one patient after irradiation for sternal metastasis [16].

We experienced successful treatment with PBT for a case of sternal metastasis of breast cancer. It is not surprising that bone metastasis is controlled well locally by PBT; however, no case similar to our case was found in the English literature in a PubMed search (available at http://www.ncbi.nlm.nih.gov/pubmed/) using “breast cancer” and “sternal metastasis” connected with “proton beam therapy” as index words. This is the first report of successful treatment with proton beam therapy for sternal metastasis from breast cancer.

Conclusion

Because this study was a case study, it is difficult to define the indication for PBT for solitary sternal metastasis of breast cancer. However, it is possible that some patients with solitary sternal metastasis of breast cancer were treated only by surgery, chemotherapy, or radiation therapy despite being potential candidates for PBT. PBT for solitary sternal metastasis of breast cancer is considered to be a therapeutic option.