Literature DB >> 3530305

The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy.

S Jawad, J Oxley, W C Yuen, A Richens.   

Abstract

Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting. In a randomised double-blind trial it was found that oral lamotrigine (240 mg) was more effective than placebo, but less effective than diazepam (20 mg) in suppressing interictal spikes. Further clinical evaluation of lamotrigine is recommended in patients with epilepsy.

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Year:  1986        PMID： 3530305      PMCID： PMC1401113          DOI： 10.1111/j.1365-2125.1986.tb05249.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  4 in total

1.  Sensitive gas chromatographic method for the determination of diazepam and N-desmethyldiazepam in plasma.

Authors:  J J de Gier; B J 't Hart
Journal:  J Chromatogr       Date:  1979-07-21

Review 2.  Clinical pharmacokinetics of diazepam.

Authors:  M Mandelli; G Tognoni; S Garattini
Journal:  Clin Pharmacokinet       Date:  1978 Jan-Feb       Impact factor: 6.447

3.  Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG.

Authors:  N Milligan; S Dhillon; J Oxley; A Richens
Journal:  Epilepsia       Date:  1982-06       Impact factor: 5.864

4.  Acute effects of intravenous phenytoin on the frequency of inter-ictal spikes in man.

Authors:  N Milligan; J Oxley; A Richens
Journal:  Br J Clin Pharmacol       Date:  1983-09       Impact factor: 4.335
  4 in total
  10 in total

1.  Could lamotrigine be useful in status epilepticus? A case report.

Authors:  F Pisani; G Gallitto; R Di Perri
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-09       Impact factor: 10.154

Review 2.  The new antiepileptic drugs.

Authors:  R E Appleton
Journal:  Arch Dis Child       Date:  1996-09       Impact factor: 3.791

Review 3.  Lamotrigine. A review of its use in childhood epilepsy.

Authors:  C R Culy; K L Goa
Journal:  Paediatr Drugs       Date:  2000 Jul-Aug       Impact factor: 3.022

Review 4.  Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy.

Authors:  K L Goa; S R Ross; P Chrisp
Journal:  Drugs       Date:  1993-07       Impact factor: 9.546

Review 5.  Newer antiepileptic drugs. Towards an improved risk-benefit ratio.

Authors:  P N Patsalos; J W Sander
Journal:  Drug Saf       Date:  1994-07       Impact factor: 5.606

Review 6.  Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy.

Authors:  A Fitton; K L Goa
Journal:  Drugs       Date:  1995-10       Impact factor: 9.546

Review 7.  Lamotrigine clinical pharmacokinetics.

Authors:  B Rambeck; P Wolf
Journal:  Clin Pharmacokinet       Date:  1993-12       Impact factor: 6.447

8.  Mechanisms of use-dependent plasticity in the human motor cortex.

Authors:  C M Bütefisch; B C Davis; S P Wise; L Sawaki; L Kopylev; J Classen; L G Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205

9.  Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model - Phenytoin and Valproate, Lamotrigine and Valproate.

Authors:  Kim Det Taing; Terence J O'Brien; David A Williams; Chris R French
Journal:  PLoS One       Date:  2017-01-11       Impact factor: 3.240

10.  Usefulness of EEG for the differential diagnosis of possible transient ischemic attack.

Authors:  Carla Bentes; Patrícia Canhão; Ana Rita Peralta; Pedro Viana; Ana Catarina Fonseca; Ruth Geraldes; Teresa Pinho E Melo; Teresa Paiva; José Manuel Ferro
Journal:  Clin Neurophysiol Pract       Date:  2017-10-18
  10 in total

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