A Clinical Review on Paroxetine and Emerging Therapies for the Treatment of Vasomotor Symptoms.

Most women experience vasomotor symptoms (VMS) during their menopausal transition. Menopausal hormone therapy (HT) is the most effective treatment for VMS, but some women choose not to use HT or have contraindications to using HT. Non-hormonal treatment options should be offered to these symptomatic menopausal women. Multiple large randomized controlled trials have demonstrated statistically significant reductions in hot flash severity and/or frequency with the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). To date, paroxetine mesylate remains the only non-hormonal treatment that has been approved by the United States Food and Drug Administration (FDA) for the management of moderate to severe postmenopausal vasomotor symptoms. Lower doses are needed to reduce VMS than those used to treat anxiety or depression, which is beneficial since side effects are typically dose dependent. The recommended dosage is 7.5 mg once daily at bedtime. Dose dependent side effects include nausea, fatigue, and dizziness. Knowing potential medication interactions is critical such as with medications that can lead to serotonin syndrome, concomitant use with monoamine oxidase inhibitors and being aware of p450 drug metabolism is essential for patients taking drugs that utilize the CYP2D6 enzyme for metabolism including tamoxifen. This review discusses in detail the available data supporting the use of paroxetine for the treatment of VMS, including side effects and considerations regarding prescribing. A discussion of other emerging treatments is included as well, including estetrol, oxybutynin and neurokinin 3 (NK3) receptor antagonists.

Introduction

Worldwide, approximately 80% of women experience bothersome hot flashes and night sweats, known as vasomotor symptoms (VMS), during the menopause transition and beyond.1,2 The central thermal regulatory neutral zone in the hypothalamus is altered when estradiol levels decline due to menopause.1 Innervation of hypothalamus involves neurons that coexpress kisspeptin, neurokinin B (NKB), and dynorphin known collectively as KNDy neurons.3–6 These KNDy neurons are stimulated by NKB and inhibited by estrogen.3–7 When estrogen levels decline in perimenopause and menopause, there is an increase in NKB signaling which then overstimulates KNDy neurons in the absence of estrogen, thereby increasing activity in the temperature control center, resulting in VMS.3–7 Consequently, this can lead to flushing, sweating and sensation of intense heat in menopausal and perimenopausal women.8 Women may also experience worsening anxiety or depression, irritability and brain fog as a result of the decline in circulating estradiol.8 Bothersome VMS have been shown to adversely impact sleep quality, work productivity, interpersonal relationships and quality of life for many postmenopausal women.9,10 Menopausal hormone therapy is an effective treatment for VMS and is considered to be a safe treatment option in healthy menopausal women when initiated before the age of 60 or within 10 years of menopause.11,12 In addition to managing bothersome menopausal symptoms, hormone therapy (HT) effectively reduces the risk of fractures associated with menopausal bone loss and osteoporosis.11,12 Multiple studies have demonstrated beneficial cardiovascular effects of timely HT use, especially in women who undergo menopause before the age of 45.13

Although HT is considered the standard treatment for managing menopausal symptoms, it is not always the best option for all women. Non-hormonal treatment options should be offered to menopausal women with bothersome VMS who have contraindications or prefer to avoid hormonal therapies. HT should be avoided in women with or at high risk for coronary heart disease, stroke, venous thromboembolism and in women with a history of estrogen dependent cancers.1,8 Multiple large randomized controlled trials (RCTs) have demonstrated statistically significant reductions in hot flash severity and/or frequency with the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) including paroxetine, escitalopram, citalopram, desvenlafaxine and venlafaxine.14–18 SSRIs contribute to VMS management through two proposed mechanisms: lowering core body temperature through central vasodilation to negate the effects that occur during menopause due to the narrowed thermoregulatory zone and by decreasing blood flow to the skin to counter the vasodilation during flushing.19 To date, paroxetine mesylate remains the only non-hormonal treatment that has been approved by the United States Food and Drug Administration (FDA) for the management of moderate to severe postmenopausal vasomotor symptoms.1 This article reviews available data for using paroxetine for the treatment of bothersome menopausal symptoms. In addition, other emerging treatments are reviewed. These emerging therapies include estetrol, oxybutynin and neurokinin 3 (NK3) receptor antagonists.

Overview of Paroxetine for VMS

Paroxetine mesylate 7.5 mg once daily at bedtime was approved by the United States FDA in 2013 solely for the treatment of VMS. While higher doses of paroxetine mesylate and paroxetine hydrochloride are available, they are reserved for the treatment of depression and other psychiatric disorders.10,20 With low dose paroxetine mesylate, improvements were found in VMS frequency and severity up to 6 months along with improvements in sleep disruption attributed to VMS without negative effects on libido or weight gain.21,22 In a position statement put out by the North American Menopause Society (NAMS) on non-hormonal options, paroxetine is considered Level I evidence for the treatment of VMS.10 Paroxetine comes in two forms: paroxetine mesylate and paroxetine hydrochloride. The mesylate and hydrochloride salts are both inactive and disassociate from active paroxetine in the gastrointestinal tract. The differences between the two salts are minor and there is no evidence that the differences have any clinical implications.23 The effect of paroxetine on reducing VMS for severe symptoms is seen as early as 1 week and as early as 2 weeks for moderate VMS symptoms, while the effect on reducing depression is seen at 6 weeks.22,24 Counseling patients on the benefits of early symptom relief of VMS without affecting weight or libido are essential. It also important for clinicians and patients to understand that the low dose is not indicated for the treatment of depression.

Clinical Studies for Use of Paroxetine for VMS

Paroxetine Hydrochloride

Initially, studies were done with paroxetine hydrochloride. Two early pilot studies in 2000 and 2002 were conducted as open-label studies for 6 weeks that showed significant hot flash reduction.25,26 In 2005, Stearns et al conducted a 4 week, double-blind, randomized, controlled, crossover study in 151 menopausal women, with the majority being breast cancer survivors. With 10 mg paroxetine HCl vs placebo, hot flash frequency was decreased by 40.6% vs 13.7% (P=0.0006). Furthermore, hot flash frequency was significantly decreased by 51.7% vs 26.6% (P=0.0002) with 20 mg paroxetine HCl vs placebo. Seventeen (11%) patients withdrew due to adverse effects. Most of the withdrawals were in the 20 mg paroxetine HCl group (n=13), with fewer in the 10 mg paroxetine HCl group (n=4). The most reported adverse effects were drowsiness and nausea.27 Overall, paroxetine HCl was associated with a 40–67% reduction in hot flash frequency with 4–6 weeks of treatment compared to 14–27% reductions with placebo. It was also associated with significant reductions in hot flash severity. The benefits of paroxetine HCl on VMS were observed within 1–2 weeks of therapy and were shown to persist throughout a 6-week treatment duration in this patient population. These trials showed both doses of paroxetine HCl – 10 mg and 20 mg – to be effective for VMS, however the 10 mg dose was better tolerated.28

Paroxetine Mesylate

Following this, 4 RCTs were conducted to assess paroxetine and VMS in women without breast cancer, including two Phase 3 placebo-controlled clinical trials looking at paroxetine mesylate.22 In these 4 trials, paroxetine was associated with a 33–65% reduction in hot flash frequency with 6–12 weeks of treatment compared to 17–38% reductions with placebo. Additionally, paroxetine was also associated with significant reductions in hot flash severity. Patient-perceived improvement was seen at 4 weeks, however patient-perceived improvement did not remain significant at 12 weeks. A 50% reduction in hot flash frequency was observed within 2 weeks of therapy and persisted throughout the 24-week treatment duration (p=0.006).22 In these trials, sleep quality was also evaluated while on paroxetine 7.5 mg daily. Patients reported a mean baseline of 3.6 awakenings per night due to VMS. They found a significant reduction in nighttime awakening from VMS at 4 weeks (39% reduction for paroxetine vs 28% placebo; P=0.0049), and these results were sustained through the 24-week treatment period (62% reduction for paroxetine vs 43% placebo; P, 0.0001). The paroxetine mesylate group also had significantly increased nighttime sleep duration at all assessments, but no differences were found in sleep-onset latency or sleep-related adverse events such as sedation.29 Although most literature supporting use of paroxetine consists of doses between 10 mg and 25 mg, significant reductions in VMS were observed with the low dose of paroxetine mesylate (7.5 mg/day). Additionally, the lower dose had a tolerable adverse effect profile and no significant withdrawal symptoms at discontinuation without tapering.28

Paroxetine Use in Men with Vasomotor Symptoms

Men who undergo androgen ablation therapy for prostate cancer are at risk for VMS, and up to 75% of men will have VMS that affect their quality of life considerably.30 A prospective pilot study was conducted using paroxetine in men experiencing VMS due to androgen ablation therapy for prostate cancer. Patients were evaluated with an initial dose of extended-release paroxetine 12.5 mg daily, escalating to 37.5 mg daily over 5 weeks. Of the 18 patients who completed the study, when compared to baseline, by week 5 study participants had a significant improvement in hot flashes, sweating, trouble sleeping and with quality of life (p<0.05).31 Thus, paroxetine may be effective for men with VMS although the United States FDA indication for the 7.5 mg paroxetine mesylate dose is for vasomotor symptoms of menopause. Additional studies are needed to evaluate the efficacy of paroxetine for vasomotor symptoms in men.

Side Effects

Compared to placebo, the most common side effects reported with paroxetine mesylate were nausea (3.8% vs 1.4%), fatigue (3.4% vs 1.5%), and dizziness (2% vs 0.8%). Reasons that prompted discontinuation that occurred in at least 2% of patients and twice as often compared with placebo included muscle cramps, spasms, and/or twitching (3.4% vs 1.5%); restless leg feeling (2.6% vs 1.2%); and insomnia (2.6% vs 1.2%).22 Although uncommon, there is a black box warning for the potential of paroxetine HCl to increase the risk of suicidal thinking and behavior, however low dose paroxetine mesylate was not tested in women who have a history of depression, suicide attempts, or psychiatric conditions.22 Other adverse effects linked to SSRI use in general include syndrome of inappropriate antidiuretic hormone secretion, bone fractures,32,33 seizures, akathisia, acute angle closure glaucoma, and cognitive and/or motor impairment.34 In the pooled analysis evaluation of the treatment’s effect on weight and sexual dysfunction, there were no statistically significant changes observed from baseline in terms of weight or sexual function in the paroxetine mesylate 7.5 mg group.35

Most adverse effects reported were of mild-to-moderate severity, with improved tolerability associated with lower doses (7.5–12.5 mg/day).28 If lower doses are not effective, dose escalation can be done, however patients may develop side effects necessitating switching to other SSRIs/SNRIs. Suggested dosing for treating VMS include paroxetine mesylate, 7.5 mg per day; paroxetine HCl, 10 to 25 mg per day; escitalopram, 10 to 20 mg per day; citalopram, 10 to 20 mg per day; desvenlafaxine, 100 to 150 mg per day; and venlafaxine, 37.5 to 150 mg per day.10 Additionally, gabapentinoids such as gabapentin 900–2400 mg per day or pregabalin 150–300 mg per day may be used for VMS.10

Contraindications and Inhibition of CYP2D6

Contraindications to SSRIs and SNRIs include serotonin syndrome (consider possible synergy with other medications such as triptans), prior neuroleptic syndrome and concurrent use of monoamine oxidase inhibitors.36 Clinicians should be aware of potential interactions with paroxetine and patients with bipolar disease, uncontrolled seizures, liver or kidney insufficiency, uncontrolled hyponatremia or poorly controlled hypertension, concurrent use of other SSRIs or SNRIs, or relevant polymorphisms in cytochrome P450 enzyme pathways. In women using tamoxifen, concurrent use of SSRIs may lead to inhibition of CYP2D6 (the enzyme that converts tamoxifen to its most active metabolite, endoxifen). The most potent inhibition of CYP2D6 occurs with paroxetine and fluoxetine, so these should be avoided in tamoxifen users. Safer choices include venlafaxine or desvenlafaxine (SNRIs) or escitalopram or citalopram (SSRIs)10 (Table 1).

Table 1

SSRI/SNRI and CYP2D6 Activity

Potent Inhibitors	Moderate Inhibitors	Weak Inhibitors	No Activity CYP2D6
Fluoxetine	Sertraline	Citalopram	Venlafaxine
Paroxetine	Duloxetine	Escitalopram	Desvenlafaxine
Bupropion	Fluvoxetine		Mirtazapine

An in vivo study of 12 women found that paroxetine decreased the mean serum concentration of the active metabolite endoxifen by 6.9 ng/mL (CI: 2.7–11.2 ng/mL; P=0.004).24,27 A study of 80 newly diagnosed breast cancer patients found that women taking potent CYP2D6 inhibitors, including paroxetine, had levels of endoxifen that were 58% lower (CI: −86.1 to −19.5; P=0.0025).37 Aubert and others conducted a trial of 1298 patients with breast cancer and compared the rate of breast cancer recurrence in patients treated with tamoxifen with or without a CYP2D6 inhibitor. Patients who were receiving a CYP2D6 inhibitor had significantly higher rates of breast cancer recurrence at 2 years, 13.9% vs 7.5%.38 Additionally, a retrospective study found that patients on paroxetine and tamoxifen had a significant increase in risk of death from breast cancer. The study consisted of 2430 women breast cancer survivors who were prescribed an SSRI along with tamoxifen were assessed for all-cause mortality and breast cancer mortality. Women who were prescribed and took paroxetine had increased breast cancer mortality. The risk was further increased based on the amount of overlapped time patients took tamoxifen with paroxetine (overlap percentage of 25% of time caused a 24% increase, 50% overlap generated a 54% increase, and 75% overlap resulted in 91% increase: P<0.05 for all). Based on the results from this study, there would be an additional death from breast cancer for every 19.7 patients who took paroxetine and tamoxifen together 41% of the time (median overlap in this study population). The risk with more extensive overlap would be even greater. This increased risk was not observed among other SSRIs that do not inhibit CYP2D6 in this study.39

It is important to consider this drug interaction because patients with a history of breast cancer who are on tamoxifen tend to report increased rates of VMS (up to 80%) and may rely on certain SSRIs or SNRIs to help with VMS.10,19,24 As a result of this interaction resulting in decreased efficacy of tamoxifen, both the National Comprehensive Cancer Network (NCCN) and the American Society of Clinical Oncology recommend using caution with concomitant use of paroxetine and tamoxifen. The NCCN and International Menopause Society specifically prefer citalopram and venlafaxine over paroxetine and fluoxetine.40

Emerging Uses for Paroxetine

A study published in 2019 showed that paroxetine caused apoptosis of breast cancer cells. Specifically, it mostly reduced the viability of MCF-7 cells in a time-and dose-dependent manner. Paroxetine also showed a synergistic effect on cell death induced by chemotherapeutic drugs in MCF-7 and MDA-MB-231 cells. Paroxetine may serve as an anticancer adjuvant to current cancer therapies for breast cancer patients with or without depression.41 It has been clinically observed that paroxetine has shown cytotoxicity on human tumor cell lines including brain, breast and colon cancers. This is due to kinase pathways involved in tumorigenesis. Studies have established that this is due to the structural similarities including size, shape, and physicochemical properties of paroxetine with many known kinase inhibitors. Consequently, it is not surprising that paroxetine is very compatible with the kinase active site.42 This provides a possibility for a new role for paroxetine in patients with breast cancer. Certainly, consideration needs to be made in those patients with breast cancer on tamoxifen therapy due to CYP2D6 inhibition as previously described.

Discussion of Patient Selection and Relevant Counseling

One must counsel patients on potential side effects that are dose dependent including nausea, fatigue, and dizziness. Bothersome side effects that can lead to discontinuation include muscle cramping, restless leg symptoms and insomnia. Knowing potential medication interactions is critical such as with medications that can lead to serotonin syndrome, concomitant use with monoamine oxidase inhibitors. Lastly, being aware of p450 drug metabolism is essential for patients taking drugs that utilize the CYP2D6 enzyme for metabolism including tamoxifen. Paroxetine can be used in women who do not wish to be on HT or breast cancer patients who are not on tamoxifen.

Due to saturable CYP2D6 metabolism, paroxetine (HCl and mesylate) exhibits nonlinear pharmacokinetics, and therefore dose adjustments can lead to disproportional changes in plasma drug levels.23 Consequently, adverse effects may be observed with dose increases. Although there are no trials directly comparing the 7.5 mg, 10 mg, and 12.5 mg doses, tolerability is comparable based on adverse event rates in similar patient populations. Additionally, there is currently no evidence that doses of 20–25 mg provide significantly greater relief than doses less than or equal to 12.5 mg, and the 25 mg dose was associated with increased frequencies of adverse effects.28 Initiate paroxetine at a low dose and titrate if there is a suboptimal response after 2 weeks.

Emerging Options for Vasomotor Symptom Management

Paroxetine can be an effective alternative to HT for treatment of vasomotor symptoms, but still has some limitations for use. The NAMS 2015 provides additional guidance on other evidence based medications and treatments that could be considered for women with VMS who cannot or choose not to use HT.10 Additionally, the following emerging medications may become acceptable alternatives for VMS treatment. Table 2 summarizes all current and emerging medications for vasomotor symptoms.

Table 2

Comparison of Non-Hormonal Options for Vasomotor Symptoms4,39,41,42,46,57,58

Medication Name and Dose	Vasomotor Symptom Effect	Common Side Effects (%)	Additional concerns
SSRIParoxetine mesylate 7.5 mg/d*Paroxetine HCl 10-25 mg/d**Citalopram 10-20 mg/d**Escitalopram 10-20 mg/d**SNRIDesvenlafaxine100-150 mg/d**Venlafaxine 37.5-150 mg/d**	Hot flash reduction from 25 – 69%Composite hot flash frequency and severity improved from 27 – 61%	Nausea or dizziness, which usually improves after 1 to 2 weeks	Avoid potent CYP2D6 inhibitors in Tamoxifen usersPatients with bipolar disease, uncontrolled seizures, liver or kidney insufficiency, uncontrolled hyponatremia or poorly controlled hypertension, concurrent use of other SSRIs or SNRIsBlack box warnings: uncommon suicidal thoughts within first few months
GabapentinoidsGabapentin 900-2,400 mg/d**Pregabalin 150-300 mg/d**	31 – 89.5% reductions in VMS	Dizziness, unsteadiness, and drowsiness which usually improves by week 4	Lower doses often effective. Start with 100-300 mg at night and up titrate until effective doseSince drowsiness is a common adverse side effect of gabapentin, it may be a good choice for women with disruptive sleep from VMS
Emerging Options
Oxybutynin 5-15 mg/d**	50-77% reduction in hot flash frequency	Dry mouth, urinary issues, constipation	Anticholinergic side effects best tolerated at lower doses
Estetrol ** ‡	Reduction of weekly hot flashes: 66% at 4 weeks; 82% at 12 weeks	Further study needed	Further study needed to establish effective dose and safety
(NK3R) antagonists ** ‡	45% to 93% reduction in number of hot flashes	Further study needed	Further study needed to establish effective dose and safety

Abbreviations: SSRI = Selective Reuptake Inhibitor; SNRI = Selective Norepinephrine Reuptake Inhibitor; NK3R = Neurokinin 3 Receptor

Notes: *FDA approved for the treatment of VMS. **Off label. ‡Further study needed to establish dose

Estetrol (E4)

In rodents, the human fetal steroid estetrol (E4) has estrogenic agonist properties in bone, vaginal tissues, endometrium, for temperature regulation and inhibiting ovulation while acting as an estrogen antagonist in breast tumor tissue.43 Early human study evaluating escalating doses of E4 (2, 5, and 10 mg) revealed that E4 appears to be safe when used for VMS, without serious adverse events over an 8-week period.44 However, a multicenter randomized study to evaluate lowest effective dose of E4 for vasomotor symptoms found 15 mg of estetrol as the minimum effective dose, while lower doses failed to reach statistical significance.44 Early studies suggested that estetrol was a weak estrogen; however, advancement of our understanding has shown that E4 has varying pharmacodynamic and metabolic properties as compared to estradiol.43,45 Estetrol has high oral bioavailability, does not enter enterohepatic circulation, and is minimally metabolized giving it a long half-life.46 While traditional forms of estrogen-containing hormone therapy have been associated with thromboembolism and increases in breast cancer E4 is suggested to have an enhanced safety profile.43,45 It does not stimulate sex hormone binding globulin, has less cytochrome inhibition than other synthetic estrogens and therefore, theoretically, has fewer drug interactions and lower venous thromboembolism risk.46,47 While encouraging, further study is needed to identify effective doses and confirm safety and side effect profiles at these doses as well as verify additional estrogenic properties of E4 in post-menopausal women.48

Oxybutynin

Oxybutynin is an anticholinergic, antimuscarinic medication traditionally used for urinary urge incontinence and overactive bladder. Anecdotal evidence suggested that oxybutynin was beneficial for generalized hyperhidrosis49 and for vasomotor symptoms in post-menopausal women taking the medication for overactive bladder.50 One prospective analysis reviewed the safety and effectiveness of oxybutynin for secondary, post-menopausal hyperhidrosis in 21 women using doses of 5 and 10 mg daily.49 A larger, multicenter, randomized, double-blind study of post-menopausal women, with moderate to severe vasomotor symptoms, evaluated doses of 15 mg extended-release oxybutynin versus placebo.50 Women treated with oxybutynin had significant improvements in moderate-to-severe vasomotor symptoms, sleep, and quality of life measures at both 4 and 12 weeks.50 In 2019 a study evaluated lower doses of oxybutynin (2.5 mg or 5 mg twice daily) in a population of women with and without breast cancer in a randomized double-blind placebo-controlled trial.51 These doses were effective at improving hot flashes, sleep, and quality of life and were safe in patients with breast cancer, not on cytotoxic therapy.51 In each of these analyses, oxybutynin was generally well tolerated, the most common side effects were dry mouth and urinary difficulties and appear to be dose dependent.49–51 At higher doses side effects may contribute to discontinuation of the medication limiting its use for some patients.50,51 Additionally, long-term use of anticholinergic medications may be associated with cognitive effects and contribute to medication interactions, especially in elderly patients.52 A recent systematic review of medications used for overactive bladder has shown an association between cognitive decline and oxybutynin use, even in patients without baseline cognitive impairment. Caution should be undertaken if using this medication in older patients.53

Neurokinin 3 (NK3) Receptor Antagonists

Study to further understand the mechanism behind vasomotor hot flashes has implicated neurokinin B (NKB) signaling on the neurokinin 3 receptor (NK3R) in specialized kisspeptin, neurokinin B and dynorphin (KNDy) neurons as a mediator in the hypothalamic-pituitary-gonadal axis and potential target for intervention.4,54,55 In rat models KNDy neurons act on thermoregulatory areas in the brain; activating NK3R reduces rat body temperature and ablation of KNDy neurons reduced cutaneous vasodilation implicated in hot flushes.4 In healthy, post-menopausal women, intravenous infusion of NKB induced hot flashes consistent with their vasomotor symptoms.6 In addition, genetic variation in the gene encoding the NK3R may be able to account for the experienced variability of hot flashes in post-menopausal women.56 A Phase 2, randomized, double-blind, placebo-controlled study evaluated the effectiveness of an oral NK3R antagonist to reduce the number of hot flashes in post-menopausal women.55 A crossover method showed proof-of-concept and overall safety in both groups of participants. Over a four-week treatment period, administration of a twice daily oral NK3R antagonist significantly reduced the number and severity of hot flashes as compared to placebo. It was generally well tolerated but was associated with rise in transaminase concentrations in a subgroup of participants.55 Of the NK3R antagonists currently in clinical development for the treatment of VMS, fezolinetant is the most advanced with several Phase III trials underway.57 A phase IIb trial of fezolinetant, the VESTA trial, showed a significant reduction in VMS frequency and severity when compared to placebo. After 12 weeks, 93% in the fezolinetant group had an improvement of moderate to severe VMS compared to 39% in the placebo group. Similarly, there was a reduction in VMS frequency with a mean of 80.7 weekly episodes at baseline to 5.7 at week 12 in the fezolinetant group compared to reduction of a mean of 72.0 weekly episodes at baseline to 39.0 at week 12 in the placebo group.58

Conclusion

Given that HT is not indicated or preferred by all patients who present with moderate to severe VMS, clinicians need to look to alternatives such as paroxetine. Paroxetine has shown excellent VMS reduction in clinical trials, is considered Level 1 evidence by NAMS as a non-hormonal treatment option for VMS. Choices include the United States FDA approved paroxetine mesylate at 7.5 mg nightly (now available in a generic) or off-label doses of paroxetine hydrochloride 10 −20 mg daily. Since both salts have shown efficacy in clinical trials, initiating therapy with paroxetine HCl 10 mg or 12.5 mg CR may be an option when availability or cost is an issue. Other options beyond paroxetine also exist, as outlined in the NAMS non hormonal management position statement. It is promising that additional non hormonal treatments have also been identified for off label use (oxybutynin) and others are being studied in clinical trials. Ultimately, having many tools available to alleviate bothersome VMS in menopause or other circumstances that lead to VMS improves patient care and outcomes.