A Retrospective Analysis of Death Among Chinese Han Patients with Schizophrenia from Shandong.

Purpose: To describe the mortality rate and cause of death among Han Chinese schizophrenia patients and to explore the risk factors affecting survival.
Methods: We performed a retrospective analysis of death among patients with schizophrenia from Jan 1, 2012, to Dec 31, 2019, using the Severe Mental Disorders Information System of Shandong Province (henceforth referred to as the SMDI system) in Shandong, China. The cohort included 72,102 patients, and 11,766 patients died during follow-up. The data in this cohort study were derived from the SMDI system. We calculated the crude mortality rate and standardized mortality rate (SMR, standardized according to the sex and age composition of the population in Shandong Province) for patients with schizophrenia. Cox regression analysis was used to analyze the risk factors affecting patient survival, and the statistical index was the hazard ratio (HR).
Results: The mean age of the cohort patients was 47.21±14.05 years; 51.79% were males, and 48.21% were females. Among them, 68.98% (49,735) had only a primary education level, 85.36% (61,549) were farmers, 64.37% (46,413) were married, and 94.01% (67,775) received community management. A total of 16.32% of the cohort died. The SMR in patients with schizophrenia was 4.9, and it was higher for males than females (4.99 versus 4.82). Among the 6 registered causes of death, physical illness had the highest SMR (5.15), followed by other causes of death (4.86), mental illness-related complications (4.57), homicide (4.31), accidents (4.13), and suicide (3.87). Higher levels of education, employment (in-service status), marriage, and urban residence were protective factors for survival among patients with schizophrenia.
Conclusion: In China, the SMR of schizophrenia is relatively high, and physical diseases are the main cause of death. We suggest that a variety of measures should be taken early to treat somatic diseases and reduce SMR in patients with schizophrenia.

Introduction

Schizophrenia is often described as one of the most severe mental disorders that affects approximately 1% of people.1 One major reason is that patients with schizophrenia have higher mortality rates than the general population, corresponding to a significant reduction in average life expectancy.2–4 Moreover, the gap between the mortality of patients with schizophrenia and the general population has widened in recent decades.5–8.Clearly, an improved evidence base is important for identifying at-risk groups, developing interventions, and addressing premature mortality.

In recent years, a series of studies have been carried out on premature mortality among patients with schizophrenia. Nevertheless, the causes have not been fully understood until now. Although unnatural causes such as suicide,7,8 and accidents9 account for a nontrivial part of the premature mortality, the vast majority of the premature mortality of patients with schizophrenia result from natural causes mainly composed of physical diseases such as cardiovascular diseases respiratory problems, diabetes and cancer.2,3,10–14 Underlying mechanisms that might explain the premature mortality of natural causes in patients with schizophrenia compared with the general population include unhealthy lifestyles, such as smoking, drinking, substance abuse and physical inactivity.15 In addition to schizophrenia per se, some antipsychotics increase the adverse effects of serious diseases such as metabolic syndrome, diabetes, and atherosclerosis, some of which are even life-threatening.16

To our knowledge, most studies on premature mortality in schizophrenia have primarily been conducted in Western countries. China’s domestic research on the mortality rate and causes of schizophrenia is insufficient. Most of the domestic studies were on schizophrenia patients in western China.17 Considering that China, especially mainland China, differs largely from Western countries in terms of background ethnicity, health care systems, availability of clinical and community services, and relevant health indexes such as obesity and smoking rates.18 Western mortality estimates for schizophrenia may not be generalizable to China.

In China, the National Continuing Management and Intervention Program for Psychoses (also known as the “686 Program”), which includes schizophrenia and five additional severe mental disorders, was implemented in 2004. Later, the “686 Program” evolved into the national essential public health service,19 which made it possible to provide free regular follow-up and rehabilitation guidance to these patients in their communities. Additionally, the establishment of a severe mental health disorder system (henceforth referred to as the SMHD system) provided an opportunity to revisit the improvements in schizophrenia mortality. By the end of 2019, Shandong province had managed nearly 440,000 patients with severe mental disorders, 66% of whom were schizophrenics. The Han nationality accounted for more than 99.7% of this population. The ratio of male to female was 97.62:100. The age distribution was mainly 18–59 years old. 81% of patients lived in rural areas. Doctors or nurses at community health centers follow up patients regularly to record their symptoms, social functioning, sleep and medication status.

The latest epidemiological studies reported that the overall lifetime prevalence of schizophrenia was 5.44 per 1000 up to July 2013.20 A 10-year prospective cohort reported that the standardized mortality ratio (SMR) for the whole cohort was 4.0; for men, it was 4.9, and for women, it was 3.3, with all 64 deaths in the schizophrenia group occurring from natural causes.21 Among these 64 deaths, the specific causes of death in 42 cases were known, including various cancers, heart disease, respiratory disease, and other diseases. A 10-year follow-up investigation among a 1994 cohort of patients with schizophrenia showed that SMR for both suicide and deaths due to other causes (accident and natural causes) was highest in young patients and lowest in geriatric patients.22 A population-based nested case–control study indicated considerably decreased mortality from natural death in patients with schizophrenia using antipsychotics.23

To protect patients’ health, China enacted a mental health law in 2013, and Shandong Province enacted mental health regulations in 2019. The Shandong provincial government released a document in 2018 to ensure free treatment for people with severe mental disorders. We conducted a retrospective study on Han Chinese patients with schizophrenia identified from the SMHDS of Shandong Province, China, to thoroughly clarify the characterizations of mortality in schizophrenia patients in the Chinese mainland after the implementation of the “686 Program”, especially to answer the following questions: 1. What are the main factors currently leading to mortality in Han Chinese patients with schizophrenia? 2. What are the effects of the policies introduced in recent years on the mortality rate of schizophrenia patients? By characterizing key sources of premature mortality in a large cohort with schizophrenia, the results provide a more comprehensive picture of the gap in mortality, thus highlighting the need for more effective strategies to improve the medical care of this patient population.

Materials and Methods

Study Population

The study population was identified based on the SMHD system, which includes the following conditions. (1) They had been registered in primary medical and health institutions before December 31, 2011. (2) They had lived in the location for more than half a year. (3) They were Han patients with schizophrenia in Shandong Province. These patients were first screened by the trained staff of primary medical and health institutions according to the “Identification List of Mental Behavior Abnormalities” (11 items) and then confirmed by senior psychiatrists designated by the local health department according to the ICD-10.

Normally, these patients come from two populations: they were either from primary medical and health institutions or they were treated at home after outpatient treatment in mental hospitals or hospitalization. With the patient’s consent, they will receive regular follow-up services from primary medical and health institutions. The SMHD system records the patient’s information as follows: (1) general demographic information (location, sex, age, race, marriage, education levels, income, and profession), (2) medical history (family history of mental illness, current diagnosis, date of initial diagnosis of schizophrenia, and the use of antipsychotic medicines), (3) information related to death (time of death, cause of death, and manner of death).

Ethical review batch number (Reference No. ECSHCMSMHC2019R42) was approved by the institutional research ethics committee of Shandong Mental Health Center. Before participating in community service management, patients or their family members were needed to sign a paper informed consent form.

There were 72,102 patients with schizophrenics in Shandong province at the end of 2011. Between 2012 and 2019, they received follow-up management services from community health services. The staff managed the patients according to their condition during each visit. A total of 11,766 patients died during that period show in Figure 1.

Figure 1

Community management process for patients with schizophrenia.

Selection of Study Subjects

We identified all patients from the study population who died between Jan 1, 2012, and Dec 31, 2019. The causes and manner of death were identified by the SMHD system administrator according to death certificates written generally by ordinary physicians or by forensic specialists if death was sudden or crime was suspected. The default causes and manner of death in the SMHD system were divided into six categories as follows: physical illness, comorbidities related to mental illness, suicide, homicide, accident, and others.

Statistical Analysis

We analyzed the crude mortality ratios (CMRs) and standardized mortality ratios (SMRs) in individuals with schizophrenia and compared them with the general population (Website of Shandong Bureau of Statistics). The death and population data were sorted out and standardized by age and sex. According to the death information of schizophrenia patients, the death composition of different feature stratifications was calculated. Cox survival analysis was adopted to analyze the characteristics of the cohort and establish a survival model to explore the factors affecting the survival of patients with schizophrenia. All statistical analyses were conducted using SPSS 22.0 software.

Results

Demographic Characteristics

The basic characteristics of the study population are shown in Table 1. A total of 72,102 patients with schizophrenia, including 34,758 males and 37,344 females, were included in the Severe Mental Disorders Management Program at the end of 2011 and were followed up from January 2012 to December 2019. The average age for males was 45.33 years (range 10–101) and 48.95 years for females (range 10–104). Elderly individuals (60- years old), primary school or below, rural residents, no family history, farmers, and married people were the majority. In male patients, the proportion gap between married and unmarried is small; among the female patients, the majority were married (83.23%), while the proportion of unmarried patients was relatively low. The mean follow-up time was 7.56 years (range: 0.1–8 years), and 11,766 patients died.

Table 1

Baseline Characteristics

Characteristics		Male		Female
		N	%	N	%
Age Group	10–39 years	11,881	34.18	9240	24.74
	40–59 years	10,715	30.83	11,270	30.18
	60- years	12,162	34.99	16,834	45.08
Education Level	Primary schools and below	21,968	63.20	27,767	74.35
	Junior/senior high school	10,205	29.36	7912	21.19
	Junior college and above	2585	7.44	1665	4.46
Urban and rural areas	Urban	3771	10.85	3336	8.93
	Rural	30,987	89.15	34,008	91.07
Family history	No	27,663	79.59	31,103	83.29
	Yes	7095	20.41	6241	16.71
Professional	Farmers	29,129	83.81	32,420	86.81
	Workers and technicians	2208	6.35	2152	5.76
	Laid off/unemployed/retired	3421	9.84	2772	7.42
Marriage status	Unmarried	15,740	45.28	3310	8.86
	Married	15,706	45.19	30,707	82.23
	Divorced/widowed	3312	9.53	3327	8.91
Follow-up time	0–2 years	33,762	97.13	36,228	97.01
	2–4 years	32,337	93.03	35,269	94.44
	4–6 years	30,421	87.52	33,643	90.09
	6–8 years	28,643	82.41	31,880	85.37

Notes: The data of the study cohort were obtained from the Mental Disorders Information System of Shandong Province.

All Causes Mortality

Differences in SMR for different characteristics of schizophrenia are shown in Table 2.The SMR was the highest in patients aged 10–39 years (5.49), followed by those aged over 60 years. The SMR of patients with primary school education or below (5.14) was higher than that of patients with other education. The SMR of rural patients (4.91) was higher than that of urban patients (4.74). 491 patients had a family history of mental illness, with a slightly higher SMR than patients without a family history. SMR varied according to the patient’s occupation. The SMR of farmers was higher than that of other occupational patients. Divorced and widowed patients had the highest SMR (5.33), while unmarried patients had the lowest (5.16). From 2011 to 2013, the SMR of patients with schizophrenia showed an increasing trend, and gradually decreased after 2014 show in Figure 2.

Table 2

Different Characteristics of Death in Schizophrenia Patients, SMRs and 95% CIs

Characteristics		Total			Male			Female
		N	CMR	SMR (95% CI)	N	CMR	SMR (95% CI)	N	CMR	SMR (95% CI)
Age Groups	10–39 years	1502	275.19	5.49 (5.34–5.63)	961	368.64	5.52 (5.38–5.66)	541	189.87	5.46 (5.32–5.60)
	40–59 years	2434	892.43	4.01 (3.88–4.13)	1458	1091.36	3.99 (3.87–4.11)	976	711.04	4.03 (3.91–4.15)
	60- years	7830	988.07	4.85 (4.72–4.99)	3784	919.50	4.50 (4.37–4.63)	4046	1051.47	5.16 (5.02–5.29)
Education Level	Primary schools and below	9571	1753.53	5.14 (5.01–5.28)	4744	1819.82	5.09 (5.01–5.19)	4827	1990.61	5.17 (5.04–5.31)
	Junior/senior high school	1829	335.10	4.06 (3.93–4.18)	1208	463.39	4.11 (3.93–4.19)	621	256.09	4.02 (3.90–4.14)
	Junior college and above	366	67.06	4.10 (3.98–4.22)	251	96.28	4.14 (4.14–4.26)	115	47.42	4.10 (3.98–4.23)
Urban and rural areas	Urban	705	129.17	4.74 (4.61–4.87)	423	162.26	4.68 (4.61–4.74)	282	116.29	4.87 (4.74–5.01)
	Rural	11,061	2026.52	4.91 (4.78–5.05)	5780	2217.24	4.83 (4.78–4.90)	5281	2177.83	4.99 (4.86–5.13)
Family history	No	11,275	2085.00	4.90 (4.76–5.03)	5847	2281.30	4.81 (4.68–4.95)	5328	1869.90	4.99 (4.85–5.12)
	Yes	491	90.80	4.96 (4.83–5.10)	256	98.20	4.94 (4.81–5.08)	235	82.48	4.98 (4.85–5.12)
Professional	Farmers	10,265	1898.24	4.92 (4.78–5.05)	5346	2050.75	4.83 (4.70–4.97)	4919	1726.36	5.00 (4.87–5.14)
	Workers and technicians	475	87.84	4.73 (4.59–4.86)	259	99.35	4.68 (4.55–4.81)	216	75.80	4.78 (4.65–4.92)
	Laid off/unemployed/retired	1026	189.73	4.81 (4.68–4.95)	598	229.40	4.76 (4.63–4.89)	428	150.21	4.92 (4.79–5.06)
Marriage status	Unmarried	2734	500.90	4.13 (4.01–4.26)	2374	910.68	4.25 (4.12–4.38)	360	148.46	3.88 (3.76–4.00)
	Married	7329	1342.77	5.16 (5.02–5.30)	3018	1157.72	5.34 (5.20–5.17)	4311	1777.81	4.99 (4.85–5.12)
	Divorced/widowed	1703	312.01	5.33 (5.19–5.47)	811	311.10	4.98 (4.85–5.11)	892	313.05	5.64 (5.50–5.78)

Notes: The death data of schizophrenia patients were obtained from the Mental Disorders Information System of Shandong Province. The general population data was obtained from the 11th National Population Census of Shandong Province (Shandong Statistical Bulletin).

Abbreviation: SMR, standardized mortality ratio (standardized for age and sex).

Figure 2

Trends in SMR-follow-up time in patients with schizophrenia (Jan 1, 2012–Dec 31, 2019). The death data of schizophrenia patients were obtained from the Mental Disorders Information System of Shandong Province. The general population data was obtained from the 11th National Population Census of Shandong Province (Shandong Statistical Bulletin).

Natural Causes of Death

Differences in SMR for different causes of schizophrenia are shown in Table 3. The CMR for schizophrenia was 2155.51 per 100,000 years, and the SMR was 4.90. Male’s CMR was higher than that of females, but the opposite was true for the SMR.In schizophrenia, 66.88% of patients died of natural causes, and 11.40% died of unnatural causes. The CMR from natural causes was 1441.70 per 100,000 years, and the SMR was 5.10 (95% CI, 4.97–5.24), with the SMR of female patients slightly higher than that of male patients (5.14 vs 5.06). For patients who died of natural causes, 92.46% died from physical illness, and the SMR was 5.15 (95% CI, 5.02–5.20); 7.54% of patients died from mental illness-related complications, and the SMR was 4.57 (95% CI, 4.44–4.71).

Table 3

Causes of Death in Schizophrenia Patients, SMRs and 95% CI

Causes of Death	Total			Male			Female
	N	CMR	SMR (95% CI)	N	CMR	SMR (95% CI)	N	CMR	SMR (95% CI)
All causes	11,766	2155.51	4.90 (4.77–5.03)	6203	2379.12	4.82 (4.69–4.95)	5563	1952.37	4.99 (4.85–5.12)
Natural causes	7869	1441.70	5.10 (4.97–5.24)	4076	1563.57	5.06 (4.92–5.19)	3793	1331.38	5.14 (5.01–5.28)
Mental illness related complications	593	108.65	4.57 (4.44–4.71)	320	122.75	4.40 (4.28–4.44)	273	95.81	4.86 (4.73–4.90)
Physical illness	7276	1333.06	5.15 (5.02–5.20)	3756	1440.82	5.13 (5.00–5.18)	3520	1235.37	5.17 (5.03–5.21)
Unnatural causes	1341	245.69	4.02 (3.90–4.15)	769	294.99	3.96 (3.83–4.08)	572	200.75	4.13 (4.00–4.25)
Accident	807	147.85	4.13 (4.01–4.17)	487	186.82	4.06 (3.93–4.09)	320	112.31	4.27 (4.14–4.31)
Homicide	13	2.38	4.31 (4.19–4.35)	6	2.30	5.44 (5.30–5.48)	7	2.46	3.65 (3.54–3.69)
Suicide	521	95.45	3.87 (3.75–3.90)	276	105.87	3.77 (3.65–3.81)	245	85.98	3.97 (3.85–4.01)
Other causes	2556	468.11	4.86 (4.73–4.99)	1358	520.55	4.73 (4.60–4.77)	1198	420.43	5.01 (4.87–5.05)

Notes: CMR are expressed per 100 000 person-years. Male and female SMRs are standardized for age.

Abbreviation: SMR, standardized mortality ratio (standardized for age and sex).

Unnatural Causes of Death

Patients with schizophrenia who died of unnatural causes had a CMR of 245.69 per 100,000 years and a SMR of 4.02 (95% CI, 3.90–4.15), which was higher in female than in male (4.13 vs 3.96) show in Table 3. Accident accounted for approximately 60% of unnatural deaths, and the SMR was 4.13 (4.01–4.17). Suicide accounts for nearly 38.85% of unnatural deaths, and female have a higher SMR than male (3.97 vs 3.77). In this cohort, a total of 13 patients with schizophrenia died from homicide (6 males and 7 females), and the SMR of male was higher than that of female.

Factors Influencing Patient Survival

We incorporated all patient data into the Cox regression analysis model and used the first group of each variable as the reference group show in Table 4. For patients with schizophrenia, workers and technicians, high education and being married are protective factors for survival (HR=0.678, 0.664, 0.791). Divorced/widowed and living in rural areas are risk factors (HR=1.270, 1.778).

Table 4

Adjusted HRs for All-Cause Mortality in Patients with Schizophrenia

Characteristics		Reference	All Causes		Natural Causes		Unnatural Causes
			HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P value
Professional	Workers and technicians	Farmers	0.678 (0.618–0.743)	0.000	0.691 (0.618–0.773)	0.000	0.491 (0.365–0.662)	0.000
	Laid off/unemployed		0.998 (0.936–1.065)	0.963	3.966 (3.892–31.046)	0.396	0.704 (0.567–0.875)	0.002
Education Level	Junior/senior high school	Primary schools and below	0.664 (0.631–0.699)	0.000	0.647 (0.607–0.690)	0.000	1.500 (1.162–1.937)	0.002
	Junior college and above		0.566 (0.509–0.628)	0.000	0.532 (0.465–0.609)	0.000	1.180 (0.902–1.545)	0.227
Marriage status	Married	Unmarried	0.791 (0.753–0.831)	0.000	0.781 (0.734–0.831)	0.000	0.960 (0.836–1.103)	0.564
	Divorced/widowed		1.270 (1.191–1.353)	0.000	1.275 (1.179–1.379)	0.000	1.150 (0.938–1.409)	0.180
Urban and rural areas	Rural	Urban	1.778 (1.647–1.918)	0.000	1.760 (1.604–1.930)	0.000	3.250 (2.436–4.336)	0.000

Notes: Models derived from Cox regression analyses. Adjusted for age and sex. Family history was not included because of coefficient no convergence.

Abbreviation: HR, hazard ratio.

Discussion

SMR in Patients with Schizophrenia

Over the past decade, several studies have shown that people with schizophrenia have higher mortality rates than the general population.24 Our research also proves this point. The SMR among Han patients with schizophrenia was 4.9 in eastern China. It is not only higher than the general population but also higher than other regions in our study. Some previous studies reported significantly higher all-cause mortality in patients with schizophrenia (2.4) among South Korean participants.5 A study in Finland showed that all-cause SMR remained stable from 1984 (2.6) to 2014 (2.7).25 A national retrospective longitudinal cohort of adults with schizophrenia in the United States showed that the all-cause SMR was 3.7.14

Our study showed that male patients had a higher CMR than female patients, and after the age structure was standardized, SMR was the opposite. The reason for this difference may be that the proportion of male elderly patients in the total population is higher than that of female patients. Some studies have shown the opposite, with men having a higher SMR than women.26

Divorced/widowed patients had a higher SMR than unmarried and married patients, which was also a risk factor for patient survival. The loss of life partners and lack of emotional support in daily life are not conducive to the recovery of the disease. A study in China showed that being married also endowed persons with schizophrenia with more familial support than their counterparts who were not married.27 Married persons with schizophrenia lived in families with higher economic status, were more likely to have a caregiver, were surrounded by more family members and were less likely to be maltreated by other family members. Female patients, in particular, have a low family economic status, and after divorce/widowhood, they generally lose their financial resources and are not guaranteed medical treatment.

In our study, 90% of patients with schizophrenia lived in rural areas, with an SMR higher than those living in urban areas. The difference in the distribution of mental health resources between urban and rural areas is due to the difference in the distribution of mental health resources. Most mental health institutions are concentrated in cities, and rural patients have poor access to medical and health services. Furthermore, the economic income of urban and rural patients is also a major influencing factor. A study in northern Europe showed that patterns of contact were different in rural, town and city surroundings, and with the exception of psychotherapy, the rural pattern was characterized by the use of less specialized services.28

Schizophrenia is a complex polygenic disease. The SMR is higher in patients with a family history of mental illness, suggesting that genetic factors may play a role in the outcome of schizophrenia deaths. A 14-year follow-up study in rural China showed that compared with individuals with a negative family history of schizophrenia, those with a positive family history of schizophrenia had a significantly higher rate of death.29 A case-control study by Laursen also found that a family history of mental disorders was associated with higher mortality from schizophrenia.30 A Danish population-based study showed that schizophrenia was associated with the polygenic risk score, family psychiatric history, and socioeconomic status.31 Our study demonstrated that a family history of schizophrenia/psychoses is partly mediated through the individual’s genetic liability.

From 2021 to 2019, SMR in patients with schizophrenia showed a trend of first increasing and then decreasing. This has something to do with the government attaching importance to mental health work and issuing a series of policies during this period. In 2013, the Mental Health Law of the People’s Republic of China was promulgated to protect the legitimate rights and interests of people with mental disorders and regulate mental health services. In 2018, the Shandong Provincial People’s government issued a document requiring free treatment for all patients with severe mental disorders, including schizophrenia. The economic burden and disease burden of patients are reduced, and treatment is guaranteed. In 2019, Shandong Province issued the Mental Health Regulations of Shandong Province in light of local conditions, clarifying the responsibilities of all departments in the service management of severe mental disorders, and making project management more standardized and normalized.

Causes of Death

Multiple studies have shown that natural death is the leading cause of death in people with schizophrenia. In a US national cohort of adults with schizophrenia, excess deaths were from cardiovascular and respiratory diseases.14 The majority of deaths (52.2%) were caused by natural diseases such as cardiovascular diseases and cancer (Finland).5 Natural (somatic) causes of death were the main cause of excess deaths, with more than half of the excess deaths in females (Sweden).32 In our study, natural causes were also the main cause of death in patients with schizophrenia, causing 66.88% of deaths, and the SMR was 5.10. Physical diseases account for more than 90% of natural causes of death. Some physical diseases are more common in people with schizophrenia, such as cardiovascular disease, cerebrovascular disease hyperlipidemia, and diabetes. Studies have shown that people with schizophrenia have fewer primary care contacts than controls who receive poorer treatment of their medical diseases.33 Additionally, some chronic physical diseases are associated with unhealthy lifestyles (such as smoking, alcohol abuse, or high-fat and high-sugar diets).34

This suggests that physical diseases that account for a greater proportion of natural deaths should be preventable by taking a series of measures. Patients can reduce the occurrence of chronic diseases by adopting a healthy lifestyle, such as quitting smoking and drinking alcohol, eating a low-salt diet, avoiding high-calorie foods, and increasing physical exercise. Additionally, going to medical institutions to receive regular physical examinations can also be early detection of physical diseases and early intervention.

The main causes of unnatural death are accidents and suicide. In Denmark, a survey based on the national registry shows that Schizophrenia is a strong independent risk factor for accidental Deaths.9 A National Cohort study of all Swedish adult has revealed accidental death are more common than suicides.35 In addition to the influencing factors indicated by previous studies, drinking is a more significant characteristic of Shandong province population. Drinking alcohol has an effect on accidents. Our previous study also showed that the prevalence of alcohol use disorder among residents over 18 years old in Shandong province was 5.27%.36

We can promote health education in the future to strengthen the responsibility of relevant departments and guardians’ consciousness as week as their safety consciousness to mobilize them to provide more attention. Additionally, strengthening the control of drugs and toxic substances and establishing a sound, long-term social and family support system are important measures for reducing the accidental death of patients with schizophrenia.

Limitations

There was bias in the selection of research objects. Schizophrenia patients with documented management in 2011 were not included in our study if their diagnoses changed over the next few years (no schizophrenia). The causes of death of patients with schizophrenia are determined out by doctors in primary health care institutions, and there may have been inaccurate categorizations. In this study, the description of the complications of physical and mental diseases was relatively macroscopic, and the names of diseases were not specified.

Conclusions

The SMR of Han Chinese schizophrenia patients is higher than that of the general population and higher than that of some countries. Natural death stations account for more than 60% of deaths from schizophrenia. These causes of death can be prevented and controlled through early intervention.