Nga Phi Thi Nguyen1,2, Thuc Luong Cong3,4, Binh Thanh Vu5, Tuan Dinh Le2,6, Thi Thanh Hoa Tran7, Binh Nhu Do8, Son Tien Nguyen1,2, Lan Ho Thi Nguyen9, Manh Van Ngo10, Hoa Trung Dinh11, Hoang Duong Huy12, Nghia Xuan Vu13, Kien Nguyen Trung14, Duong Ngoc Vu15, Nghia The Pham15. 1. Department of Endocrinology, Military Hospital 103, Hanoi, Vietnam. 2. Department of Rheumatology and Endocrinology, Vietnam Military Medical University, Hanoi, Vietnam. 3. Cardiovascular Center, Military Hospital 103, Hanoi, Vietnam. 4. Department of Cardiology, Vietnam Military Medical University, Hanoi, Vietnam. 5. Department of Internal Medicine, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam. 6. Center of Emergency, Critical Care Medicine and Clinical Toxicology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam. 7. Emergency Resuscitation Department, National Hospital of Endocrinology, Hanoi, Vietnam. 8. Division of Military Science, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam. 9. Department of General Internal Medicine, National Hospital of Endocrinology, Hanoi, Vietnam. 10. Postgraduate Training Management Department, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam. 11. Department of Requested Treatment, National Hospital of Endocrinology, Hanoi, Vietnam. 12. Department of Neurology, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam. 13. Department of Blood Transfusion, 108 Military Central Hospital, Hanoi, Vietnam. 14. Department of Science Management, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam. 15. Department of Imaging Diagnosis, Hanoi Medical University, Hanoi, Vietnam.
Abstract
Introduction: Low albumin levels, high levels of high-sensitivity C-reactive protein (hs-CRP), and high white blood cell count were risk factors for changes in arterial intima-media thickness (IMT). Femoral artery IMT damages were one of the common peripheral artery type 2 diabetes. This study was conducted to determine the association between femoral artery IMT and plasma albumin, hs-CRP levels, and white blood cell count in newly diagnosed patients with type 2 diabetes mellitus (nT2D). Materials and Methods: From January 2015 to May 2020, 306 patients with nT2D were recruited for this cross-sectional descriptive study at Vietnam's National Endocrinology Hospital. We measured IMT by Doppler ultrasound. Results: There was a statistically significant difference in albumin, hs-CRP levels, hs-CRP-to-albumin ratio, and white blood cell counts between three different IMT groups namely normal IMT, thick IMT, and atherosclerosis (p = 0.003, p = 0.001, p = 0.001 and p = 0.049, respectively). In the multivariate linear regression analysis, white blood cell count, and hs-CRP levels showed a significantly positive correlation to IMT (standardized B and p of 0.17, 0.015 and 0.163, 0.024, respectively), but albumin levels were a significantly negative correlation to IMT (standardized B = -0.151, p = 0.029). The multivariate logistic regression analysis showed that albumin (OR = 0.79, 95% CI 0.65-0.90, p = 0.018), hs-CRP (OR = 1.09, 95% CI 1.01-1.18, p = 0.026), and white blood cell count (OR = 1.36, 95% CI 1.03-1.81, p = 0.033) had correlation to atherosclerosis of femoral artery. Conclusion: Reduced plasma albumin, elevated hs-CRP, and white blood cell count associated with IMT increased the odds for atherosclerosis of femoral artery among nT2D.
Introduction: Low albumin levels, high levels of high-sensitivity C-reactive protein (hs-CRP), and high white blood cell count were risk factors for changes in arterial intima-media thickness (IMT). Femoral artery IMT damages were one of the common peripheral artery type 2 diabetes. This study was conducted to determine the association between femoral artery IMT and plasma albumin, hs-CRP levels, and white blood cell count in newly diagnosed patients with type 2 diabetes mellitus (nT2D). Materials and Methods: From January 2015 to May 2020, 306 patients with nT2D were recruited for this cross-sectional descriptive study at Vietnam's National Endocrinology Hospital. We measured IMT by Doppler ultrasound. Results: There was a statistically significant difference in albumin, hs-CRP levels, hs-CRP-to-albumin ratio, and white blood cell counts between three different IMT groups namely normal IMT, thick IMT, and atherosclerosis (p = 0.003, p = 0.001, p = 0.001 and p = 0.049, respectively). In the multivariate linear regression analysis, white blood cell count, and hs-CRP levels showed a significantly positive correlation to IMT (standardized B and p of 0.17, 0.015 and 0.163, 0.024, respectively), but albumin levels were a significantly negative correlation to IMT (standardized B = -0.151, p = 0.029). The multivariate logistic regression analysis showed that albumin (OR = 0.79, 95% CI 0.65-0.90, p = 0.018), hs-CRP (OR = 1.09, 95% CI 1.01-1.18, p = 0.026), and white blood cell count (OR = 1.36, 95% CI 1.03-1.81, p = 0.033) had correlation to atherosclerosis of femoral artery. Conclusion: Reduced plasma albumin, elevated hs-CRP, and white blood cell count associated with IMT increased the odds for atherosclerosis of femoral artery among nT2D.