Perspectives and Management Strategies for Acute Colonic Intramural Hematoma.

Acute intramural hematoma of the colon is a rarely encountered clinical condition with diverse precipitating factors. Different acute and chronic complications emerge following hematoma formation, mandating high clinical suspicion for early diagnosis and optimum management. CECT represents the cornerstone for the proper demonstration of colonic hematomas and possible detection of complications as well as the underlying etiology. There are multiple strategies for management of intramural hematoma and treatment should be tailored according to the etiology and the clinical condition of the patient, reserving surgical intervention for unstable or complicated cases. Endoscopic management of colonic hematomas offers a promising minimally invasive modality with potential safety and efficacy.

Introduction

Intramural hematoma may occur at any site from the esophagus to the rectum, with the duodenum being the most common site for it.1 On the other hand, intramural hematoma of the colon is a rare entity with only few cases reported where sigmoid colon is the typical site.2 Spontaneous colonic hematoma is an uncommon disease and it is usually diagnosed at a late stage.3 It has been most commonly associated with blunt trauma. However, other risk factors including bleeding diathesis, malignancies, chemotherapy, vasculitis, collagen diseases, H. Pylori infection and colonic diverticular disease can be incriminated.1,4 Additionally, a case report of a huge submucosal hematoma complicating an angiodysplastic lesion in the sigmoid colon was reported in the literature.5 Rarely did it occur as an iatrogenic sequale, or as a rare complication of anticoagulant therapy or vaginal delivery.2 According to Zhu et al and Yavari et al, despite the rarity of bowel hematoma incidence, it should be considered as an adverse drug reaction of low molecular weight heparin or warfarin therapy, especially among cases presenting with gastrointestinal symptoms with or without prolonged INR.6,7 Gastrointestinal hematomas are estimated to occur in only 1 in every 250,000 anti-coagulated patients; with small intestinal hematoma reported in 1/2500 anticoagulated patients per year and far fewer reported colonic hematoma cases.8,9 Colonic trauma can occur in only 0.5–5% of those exposed to blunt abdominal injuries,10 with a very uncommon incidence of colonic intramural hematoma. It is suggested that the taenia coli plays a major protective role in cases of blunt trauma resulting in rupture of intramural vessels as it prevents the extravasation of blood into the bowel wall, which explains the rare incidence of hematoma in the colon.1

Diagnosis is majorly accomplished radiologically with contrast-enhanced computed tomography (CECT) scan or magnetic resonance imaging. Surgical management used to be the standard treatment for traumatic acute colonic intramural hematoma in most of the reported cases. On the other hand, conservative management was reserved for very few cases where no local or systemic signs of hemodynamic instability were detected.

Pathophysiology

Traumatic acute intramural hematoma is thought to originate from blood reaching the bowel wall from mesentery as a result of crushing forces inducing shearing of bowel layers and rupture of terminal blood vessels.11 Another postulated mechanism leading to bowel intramural hematoma might be the rapid decompression of splanchnic circulation due to decreased abdominal pressure, causing the bowel to rupture and bleed in cases on therapeutic anticoagulation therapy.6 The most involved bowel segments with traumatic acute hematoma are those residing between retroperitoneally free and fixed structures; with duodenum being the most commonly affected region followed by ascending colon or caecum.12

Diagnosis and Complications

The clinical symptoms of colonic hematoma are usually nonspecific and can vary from mild, crampy abdominal pain to hemorrhagic shock. Nausea and vomiting are detected in 50% of cases and are related to intestinal obstruction.6 Physical examination might reveal rebound tenderness, abdominal guarding, hematochezia, or signs of bowel obstruction.2 Early and late complications can arise as a result of intramural hematoma. At the acute phase, it might lead to blood loss by free rupture of hematoma into the peritoneum causing hemodynamic instability, bowel gangrene, intestinal obstruction, and intussusception.12 On the other hand, late complications can be in the form of stenotic lesion causing luminal obstruction due to fibrosis. Contrast-enhanced CT (CECT) along with colonoscopy is the modality of choice for diagnosis of colonic intramural hematoma.13 It has been suggested that non-contrast CT should be performed for oral and intravenous contrast medium application, as contrast-enhanced CT alone may mask the presence of intramural hemorrhage.6 Computed tomography diagnostic criteria of colonic hematomas include eccentric or circumferential wall thickening, intramural hyper-density, narrowing of the lumen and intestinal obstruction, as shown in Figure 1.14 In addition to defining hemorrhagic areas, CT can also detect possible complications as well as the underlying etiology leading to hematoma formation. Two additional signs can be detected in intramural hematoma: “coiled spring” and “pseudokidney” signs.15 Ultrasonography and CT show 71.4% and 80–100% sensitivity, respectively, for detecting such findings.16 Rigid proctoscopy is considered a precious adjunctive diagnostic modality which demonstrates colonic intramural hematomas as round-shaped, dark-reddish submucosal masses or lesions often causing luminal obstruction of the lumen.17 On the other hand, colonoscopy could reveal a localized, submucosal mass with variable mucosal manifestations, as shown in Figure 2, which demonstrates a case of colonoscopy-induced intramural hematomas in a 16-year-old patient most likely secondary to looping of colonoscope and loop reduction maneuvers.2,18 Different signs can be illustrated by barium studies denoting the presence of intramural hematoma, including coiled spring or picket fence sign or stacked coin sign.11 Repeated abdominal ultrasonography can assist in follow up of patients.

Figure 1

Contrast-enhanced computed tomography (CECT) abdomen showing intramural hematoma (arrow) of ascending colon. (A) Coronal view and (B) sagittal view.

Figure 2

Colonic vascular lesions. Four discrete lesions seen in splenic flexure, descending colon and sigmoid colon, which are most likely intramural hematomas resulting from colonoscopy-induced trauma.

Management

The diagnosis of intramural hematoma poses a challenge, particularly in the absence of clinical suspicion. An early recognition is mandatory for a positive outcome.19 The optimum treatment should be tailored according to the underlying cause in addition to the patient’s clinical condition.2 Conservative management can be considered in case of clinically and hemodynamically stable cases without signs of peritoneal affection.20 It consists of anticoagulation cessation with reversal of coagulation if the patient was anticoagulated, total parenteral nutrition and intravenous hydration for resuscitation.2,6 Nevertheless, the patient should be under close observation for alarming manifestations including acute anemia, evidence of expanding hematoma, and abdominal tenderness, guarding or rigidity. Usually, a minority of cases of colonic hematomas stabilize under conservative management alone. It should be noted that identification of patients with self-limiting intramural hematoma from those with more severe pathology represents a serious clinical challenge as routine clinical examination is insufficient to identify serious life-threatening cases and even a simple hematoma may also present with hyperthermia, leukocytosis and peritoneal signs.17

Indications of surgical intervention are variable and include evidence of ongoing arterial bleeding into hematoma detected in CECT arterial phase, evolving signs of peritonitis or a failure of stabilization despite conservative management.21 In patients undergoing laparotomy, a diversion stoma is one treatment option.3 It should be mentioned that diverting colostomies were required in about 80% of cases with distal colonic hematomas, as demonstrated in many case series.22

It is of utmost importance to manage a hematoma in an early stage as this prevents intestinal obstruction and obviates the need for surgery and bowel resection.16 Alternative treatment modalities have been described in case reports and series including endoscopic drainage; however, it requires colonic wall viability and it can cause relief of the “tamponade effect” of the hematoma.23 Another valuable line of treatment includes selective mesenteric embolization in patients with active bleeding into the colonic wall, with an 85% success rate, and an overall 20% of complications as a result of the procedure. A recent review of the literature demonstrates a shift in the management of colonic hematomas over the past 50 years where surgical management was the treatment of choice;24 however, since 2010 there has been a recent trend towards more conservative management.6,7,16

Endoscopic Management

Endoscopic procedures can be incriminated in many cases of acute intramural hematomas of the gastrointestinal tract, especially in those receiving anticoagulant therapy or those with concomitant hematological disorders.25 Although an intramural hematoma can be primarily associated with an invasive endoscopic procedure, including biopsy or therapeutic procedures, an incidence of spontaneous intramural hematomas during a diagnostic colonoscopy has been reported in a few cases.13

While CT offers the most sensitive diagnostic modality of intramural colonic hematoma, colonoscopy could be an adjunctive method revealing a localized submucosal lesion.2 Echo-endoscopy or endoscopic ultrasound (EUS) can be a valuable diagnostic tool in cases of intramural hematoma at an accessible location of the lesion. EUS can assist in determining the wall thickness and involvement and evaluating intra-lesional structures.26

By reviewing different case reports of colonic hematoma, it was illustrated that, as mentioned earlier, management options vary from conservative management in stable patients and surgical management for unstable or complicated patients.3,16 Nevertheless, there remain some cases where endoscopy might pose a potential role not only in diagnosis but also in offering a minimally invasive interventional modality for management of colonic hematoma. However, performing colonoscopy in the setting of an intramural hematoma might further complicate the hemorrhage as the tissue contained in hematoma can be fragile.1

Kwon et al reported a case of colonic hematoma which was developed in the sigmoid colon during colonoscopy. It was supposed to be precipitated by a continuous suctioning process applied during the procedure due to poor bowel preparation. At the suspected site of bleeding, endoscopic clips were applied, which successfully led to cessation of hematoma growth, followed by a dual knife which was used to excise and evacuate the hematoma with an electrosurgical unit and Endocut I setting as a power source.27

Similarly, Ulla-Rocha et al reported two cases of perigastric and perirectal hematomas, which were successfully managed endoscopically with fine needle aspiration (EUS-FNA)-guided drainage and stent placement, highlighting the safety and efficacy of endoscopic intervention in management of colonic hematoma.28

Another case of intramural hematoma but in the duodenum was approached endoscopically using a similar perspective by Kwon et al. The site of the suspected hematoma was punctured and incised with an electrical needle knife. After the site was punctured, a large amount of liquefied dark red-colored material gushed out from the hematoma, relieving the luminal obstruction and stenosis.23

In conclusion, intramural hematoma of the colon is a rare clinical entity which has variable precipitating factors and non-specific manifestations. High clinical suspicion is required and early recognition helps to avoid complications and abates the need for unnecessary surgical interference. Endoscopic management of intramural hematoma might offer an alternative less-invasive modality and has been reported in sporadic cases with successful and favorable outcomes.