Wilson Chen1, Heather M Ochs-Balcom2, Changxing Ma3, Paul J Isackson4, Georgirene D Vladutiu4,5,6, Jasmine A Luzum1. 1. Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI 48109, USA. 2. Department of Epidemiology & Environmental Health, School of Public Health & Health Professions, University at Buffalo, Buffalo, NY 14214, USA. 3. Department of Biostatistics, School of Public Health & Health Professions, University at Buffalo, Buffalo, NY 14214, USA. 4. Department of Pediatrics, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA. 5. Department of Neurology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA. 6. Department of Pathology & Anatomical Sciences, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Abstract
Aim: To determine the association of coenzyme Q10 (CoQ10) use with the resolution of statin-associated muscle symptoms (SAMS). Patients & methods: Retrospective analysis of a large, multicenter survey study of SAMS (total n = 511; n = 64 CoQ10 users). Univariate and multivariate logistic regression models assessed the association between CoQ10 use and the resolution of SAMS. Results: The frequency of SAMS resolution was similar between CoQ10 users and non-users (25% vs 31%, respectively; unadjusted odds ratio [OR]: 0.75 [95% CI: 0.41-1.38]; p = 0.357). Similarly, CoQ10 use was not significantly associated with the resolution of SAMS in multivariable models adjusted for SAMS risk factors (OR: 0.84 [95% CI: 0.45-1.55]; p = 0.568) or adjusted for significant differences among CoQ10 users and non-users (OR: 0.82 [95% CI: 0.45-1.51]; p = 0.522). Conclusion: CoQ10 was not significantly associated with the resolution of SAMS.
Aim: To determine the association of coenzyme Q10 (CoQ10) use with the resolution of statin-associated muscle symptoms (SAMS). Patients & methods: Retrospective analysis of a large, multicenter survey study of SAMS (total n = 511; n = 64 CoQ10 users). Univariate and multivariate logistic regression models assessed the association between CoQ10 use and the resolution of SAMS. Results: The frequency of SAMS resolution was similar between CoQ10 users and non-users (25% vs 31%, respectively; unadjusted odds ratio [OR]: 0.75 [95% CI: 0.41-1.38]; p = 0.357). Similarly, CoQ10 use was not significantly associated with the resolution of SAMS in multivariable models adjusted for SAMS risk factors (OR: 0.84 [95% CI: 0.45-1.55]; p = 0.568) or adjusted for significant differences among CoQ10 users and non-users (OR: 0.82 [95% CI: 0.45-1.51]; p = 0.522). Conclusion: CoQ10 was not significantly associated with the resolution of SAMS.
Authors: Jasmine A Luzum; Joseph P Kitzmiller; Paul J Isackson; Changxing Ma; Marisa W Medina; Anees M Dauki; Eduard B Mikulik; Heather M Ochs-Balcom; Georgirene D Vladutiu Journal: Cell Metab Date: 2015-04-07 Impact factor: 27.287
Authors: Heather M Ochs-Balcom; Ly Minh Nguyen; Changxing Ma; Paul J Isackson; Jasmine A Luzum; Joseph P Kitzmiller; Mark Tarnopolsky; Michael Weisman; Lisa Christopher-Stine; Wendy Peltier; Robert L Wortmann; Georgirene D Vladutiu Journal: Muscle Nerve Date: 2019-01-11 Impact factor: 3.217
Authors: Rhonda M Cooper-DeHoff; Mikko Niemi; Laura B Ramsey; Jasmine A Luzum; E Katriina Tarkiainen; Robert J Straka; Li Gong; Sony Tuteja; Russell A Wilke; Mia Wadelius; Eric A Larson; Dan M Roden; Teri E Klein; Sook Wah Yee; Ronald M Krauss; Richard M Turner; Latha Palaniappan; Andrea Gaedigk; Kathleen M Giacomini; Kelly E Caudle; Deepak Voora Journal: Clin Pharmacol Ther Date: 2022-03-11 Impact factor: 6.903