| Literature DB >> 3529673 |
J A Anthoons, E A Van Marck, P L Gigase.
Abstract
Sera from rats with chronic Trypanosoma brucei gambiense infection were tested for autoantibodies by an indirect immunofluorescence assay. All the sera contained IgM autoantibodies which reacted with blood vessel walls. On cultured vascular smooth muscle cells positive sera reacted with cytoplasmic filaments which were rearranged into perinuclear coils of filaments in colcemid-pretreated smooth muscle cells. These observations strongly suggest that the cytoplasmic autoantigens are intermediate filaments (I.F.). It is probable that the anti-intermediate filament autoantibodies result from polyclonal lymphocyte activation, since in rats experimentally infected with T.b. gambiense the appearance of these autoantibodies occurs already 1 week post-infection.Entities:
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Year: 1986 PMID： 3529673 DOI： 10.1007/bf00927888
Source DB: PubMed Journal: Z Parasitenkd ISSN： 0044-3255