Xuan Ma1, Facheng Li1. 1. The 18th Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100144, P. R. China.
Abstract
Objective: To review the application progress, mechanism, application points, limitations, and oncological safety of external volume expansion (EVE) assisted autologous fat grafting for breast reconstruction and provide a reference for optimizing the design of EVE. Methods: Based on the latest relevant articles, the basic experiments and clinical applications of EVE were summarized. Results: EVE can reduce interstitial fluid pressure, increase blood supply, and promote adipogenic differentiation, thereby benefiting the survival of transplanted fat. EVE assisted autologous fat grafting in clinical practice can improve the retention rate of breast volume and the outcome of breast reconstruction, meanwhile it doesn't increase the risk of local recurrence. But there is no standard parameters for application, and there are many complications and limitations. Conclusion: EVE improves the survival of transplanted fat, but its complications and poor compliance are obvious, so it is urgent to further investigate customized products for breast reconstruction after breast cancer and establish relevant application guidelines.
Objective: To review the application progress, mechanism, application points, limitations, and oncological safety of external volume expansion (EVE) assisted autologous fat grafting for breast reconstruction and provide a reference for optimizing the design of EVE. Methods: Based on the latest relevant articles, the basic experiments and clinical applications of EVE were summarized. Results: EVE can reduce interstitial fluid pressure, increase blood supply, and promote adipogenic differentiation, thereby benefiting the survival of transplanted fat. EVE assisted autologous fat grafting in clinical practice can improve the retention rate of breast volume and the outcome of breast reconstruction, meanwhile it doesn't increase the risk of local recurrence. But there is no standard parameters for application, and there are many complications and limitations. Conclusion: EVE improves the survival of transplanted fat, but its complications and poor compliance are obvious, so it is urgent to further investigate customized products for breast reconstruction after breast cancer and establish relevant application guidelines.
Entities:
Keywords:
Breast reconstruction; breast cancer; external volume expansion; fat grafting
Authors: G Giatsidis; L Cheng; Anthony Haddad; K Ji; J Succar; L Lancerotto; J Lujan-Hernandez; P Fiorina; H Matsumine; D P Orgill Journal: Angiogenesis Date: 2017-11-17 Impact factor: 9.596
Authors: Roger K Khouri; Roger K Khouri; Gingo Rigotti; Alessandra Marchi; Eufemiano Cardoso; Silvia C Rotemberg; Thomas M Biggs Journal: Plast Reconstr Surg Date: 2014-04 Impact factor: 4.730
Authors: Michael S Chin; Rei Ogawa; Luca Lancerotto; Giorgio Pietramaggiori; Kevin T Schomacker; Jasmine C Mathews; Saja S Scherer; Paul Van Duyn; Michael J Prsa; Mark P Ottensmeyer; Aristidis Veves; Dennis P Orgill Journal: Tissue Eng Part C Methods Date: 2010-06 Impact factor: 3.056
Authors: Luca Lancerotto; Michael S Chin; Brian Freniere; Jorge R Lujan-Hernandez; Qiong Li; Alessandro Valderrama Vasquez; Franco Bassetto; Daniel A Del Vecchio; Janice F Lalikos; Dennis P Orgill Journal: Plast Reconstr Surg Date: 2013-09 Impact factor: 4.730
Authors: Yvonne I Heit; Luca Lancerotto; Ildiko Mesteri; Maximilian Ackermann; Maria F Navarrete; Collin T Nguyen; Srinivasan Mukundan; Moritz A Konerding; Daniel A Del Vecchio; Dennis P Orgill Journal: Plast Reconstr Surg Date: 2012-09 Impact factor: 4.730