Samannay Das1, Archana Kashyap2, Nidhi Chopra1, Kailash C Aggarwal2, Aroonima Misra3, Amitabh Singh1. 1. Division of Pediatric Hematology/Oncology, Department of Pediatrics, VMMC and Safdarjung Hospital New Delhi 110029, India. 2. Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital New Delhi 110029, India. 3. ICMR-National Institute of Pathology, Safdarjung Hospital Campus New Delhi 110029, India.
Abstract
INTRODUCTION: Hodgkin lymphoma is a malignant proliferation of lymphatic system which when advanced can involve the bone marrow. It is usually indolent and responds to chemotherapy. However the prediction of rapidly progressive disease is often dependent on lot of clinicopathological parameters. Serum ferritin may act as a marker for disease activity in these patients. But the prior studies have failed to establish its role or group the patients into prognostic categories. AIMS: To study the status of serum ferritin at time of admission and after completion of chemotherapy and also iron overload induced organ involvement in the form of hepatic, cardiovascular and thyroid dysfunction in nine patients admitted in our ward with Hodgkin lymphoma and receiving treatment in the form of chemotherapy. METHODOLOGY: A spectrum of clinicopathological variables were tested at baseline and after treatment liver function test, thyroid function test, 2D echocardiography, Ultrasound abdomen, PET scan and serum ferritin level. CONCLUSION: Serum ferritin at baseline statistically correlated with disease activity however the final ferritin values reduced to significant values in patient that underwent remission, and hence grouping of patients based on serum ferritin values can serve as better outcome predictors. Although transfusion requirement was very rare in the patients the levels of serum ferritin correlated with disease activity. Serum ferritin level may act as a predictor of disease activity and remission. AJBR
INTRODUCTION: Hodgkin lymphoma is a malignant proliferation of lymphatic system which when advanced can involve the bone marrow. It is usually indolent and responds to chemotherapy. However the prediction of rapidly progressive disease is often dependent on lot of clinicopathological parameters. Serum ferritin may act as a marker for disease activity in these patients. But the prior studies have failed to establish its role or group the patients into prognostic categories. AIMS: To study the status of serum ferritin at time of admission and after completion of chemotherapy and also iron overload induced organ involvement in the form of hepatic, cardiovascular and thyroid dysfunction in nine patients admitted in our ward with Hodgkin lymphoma and receiving treatment in the form of chemotherapy. METHODOLOGY: A spectrum of clinicopathological variables were tested at baseline and after treatment liver function test, thyroid function test, 2D echocardiography, Ultrasound abdomen, PET scan and serum ferritin level. CONCLUSION: Serum ferritin at baseline statistically correlated with disease activity however the final ferritin values reduced to significant values in patient that underwent remission, and hence grouping of patients based on serum ferritin values can serve as better outcome predictors. Although transfusion requirement was very rare in the patients the levels of serum ferritin correlated with disease activity. Serum ferritin level may act as a predictor of disease activity and remission. AJBR
Authors: Kyung Ah Yoh; Ho Sup Lee; Lee Chun Park; Eun Mi Lee; Seong Hoon Shin; Dae Jin Park; Byeong Jin Ye; Yang Soo Kim Journal: Clin Lymphoma Myeloma Leuk Date: 2013-10-01