Literature DB >> 35288674

Pyroptosis and pyroptosis-inducing cancer drugs.

Fan Yang1, Sahana N Bettadapura2, Mark S Smeltzer3, Hua Zhu4, Shanzhi Wang5.   

Abstract

Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death. In this review, we discuss the roles of the GSDM family for anti-cancer functions and various antitumor drugs that could activate the pyroptosis pathways.
© 2022. The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society.

Entities:  

Keywords:  GSDMD; GSDME; apoptosis; caspase; inflammasome; pyroptosis

Mesh：

Substances：

Year:  2022        PMID： 35288674      PMCID： PMC9525650          DOI： 10.1038/s41401-022-00887-6

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   7.169


  114 in total

1.  Delicious poison: arsenic trioxide for the treatment of leukemia.

Authors:  Y L Kwong; D Todd
Journal:  Blood       Date:  1997-05-01       Impact factor: 22.113

Review 2.  Anthocyanins: natural colorants with health-promoting properties.

Authors:  Jian He; M Monica Giusti
Journal:  Annu Rev Food Sci Technol       Date:  2010

3.  Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma.

Authors:  Er Yue; Gulnara Tuguzbaeva; Xi Chen; Ying Qin; Anqi Li; Xi Sun; Chaorun Dong; Yanyan Liu; Yahan Yu; Syeda Madiha Zahra; Qiusheng Shan; Yanan Jiang; Zhimin Du; Yunlong Bai
Journal:  Phytomedicine       Date:  2018-09-26       Impact factor: 5.340

4.  A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease.

Authors:  Kareem L Graham; Jian V Zhang; Susanna Lewén; Thomas M Burke; Ton Dang; Maria Zoudilova; Raymond A Sobel; Eugene C Butcher; Brian A Zabel
Journal:  PLoS One       Date:  2014-12-01       Impact factor: 3.240

5.  A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma.

Authors:  Mengjiao Wu; Yan Wang; Di Yang; Ying Gong; Feng Rao; Rui Liu; Yeerken Danna; Jinting Li; Jiawen Fan; Jie Chen; Weimin Zhang; Qimin Zhan
Journal:  EBioMedicine       Date:  2019-03-12       Impact factor: 8.143

6.  Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment.

Authors:  Jian Hu; Yi Dong; Li Ding; Yang Dong; Zhihua Wu; Wenping Wang; Ming Shen; Yourong Duan
Journal:  Signal Transduct Target Ther       Date:  2019-09-06

Review 7.  The NLRP1 and CARD8 inflammasomes.

Authors:  Cornelius Y Taabazuing; Andrew R Griswold; Daniel A Bachovchin
Journal:  Immunol Rev       Date:  2020-06-19       Impact factor: 12.988

Review 8.  Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity.

Authors:  Ayesha Zahid; Hazrat Ismail; Bofeng Li; Tengchuan Jin
Journal:  Front Immunol       Date:  2020-11-30       Impact factor: 7.561

9.  Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome.

Authors:  Shigekazu Tanaka; Youichi Mizushina; Yoriko Kato; Masaru Tamura; Toshihiko Shiroishi
Journal:  G3 (Bethesda)       Date:  2013-10-03       Impact factor: 3.154

10.  DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.

Authors:  Darren C Johnson; Cornelius Y Taabazuing; Marian C Okondo; Ashley J Chui; Sahana D Rao; Fiona C Brown; Casie Reed; Elizabeth Peguero; Elisa de Stanchina; Alex Kentsis; Daniel A Bachovchin
Journal:  Nat Med       Date:  2018-07-02       Impact factor: 53.440
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  6 in total

1.  Development and validation of a combined ferroptosis- and pyroptosis-related gene signatures for the prediction of clinical outcomes in lung adenocarcinoma.

Authors:  Xuyu Gu; Shiyou Wei; Bing Chen; Wentian Zhang; Shiya Zheng
Journal:  Am J Cancer Res       Date:  2022-08-15       Impact factor: 5.942

2.  A novel pyroptosis-related gene signature for predicting laryngeal carcinoma prognosis.

Authors:  Haopeng Zhang; Lihua Wang; Ziming Yin; Lin Ji; Yu Guo
Journal:  Int J Clin Exp Pathol       Date:  2022-08-15

3.  Exploring the Potential of Pyroptosis-Related Genes in Predicting Prognosis and Immunological Characteristics of Pancreatic Cancer From the Perspective of Genome and Transcriptome.

Authors:  Jing Zhang; Xiaomin You; Dong Kang; Guoxiong Zhou
Journal:  Front Oncol       Date:  2022-06-16       Impact factor: 5.738

4.  Pyroptosis-related gene-based prognostic signature for predicting the overall survival of oral squamous cell carcinoma patients.

Authors:  Deliang Zeng; Xiao Wang; Shuning Zhang; Ao Zheng; Qingfeng Huang; Lingyan Cao
Journal:  Front Surg       Date:  2022-08-19

5.  Cuproptosis-related gene index: A predictor for pancreatic cancer prognosis, immunotherapy efficacy, and chemosensitivity.

Authors:  Xufeng Huang; Shujing Zhou; János Tóth; András Hajdu
Journal:  Front Immunol       Date:  2022-08-25       Impact factor: 8.786

Review 6.  Pyroptosis and respiratory diseases: A review of current knowledge.

Authors:  Jialiang Sun; Yanan Li
Journal:  Front Immunol       Date:  2022-09-30       Impact factor: 8.786
  6 in total

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