Derrick Ssewanyana1,2, Julia A Knight2,3, Stephen G Matthews1,4,5,6,7, Jody Wong2, Nadya Adel Khani2, Jennifer Lye2, Kellie E Murphy6,7, Kim Foshay7, Justin Okeke7, Stephen J Lye1,4,5,6,7, Rayjean J Hung8,9. 1. Alliance for Human Development, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada. 2. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada. 3. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. 4. Department of Physiology, University of Toronto, Toronto, ON, Canada. 5. Department of Medicine, University of Toronto, Toronto, ON, Canada. 6. Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada. 7. Department of Obstetrics and Gynaecology, Sinai Health System, Toronto, ON, Canada. 8. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca. 9. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.
Abstract
BACKGROUND: Maternal prenatal psychological distress (PPD) is increasingly linked to sub-optimal child neurodevelopment. Daily intake of prenatal vitamin during pre-conception and early pregnancy may ameliorate the effects of PPD on cognition in the offspring. METHODS: PPD was assessed in early (12-16 weeks) and late (28-32 weeks) gestation in the Ontario Birth Study. Prenatal vitamin supplement intake information was collected in early gestation. Child cognition at 4 years was assessed using the NIH Toolbox. Poisson regression was used to investigate associations between PPD and/or prenatal vitamin intake and child cognition. RESULTS: Four hundred and eighteen mother-child dyads were assessed. Moderate-severe PPD experienced during early gestation was associated with reduced cognition (adjusted incidence rate ratio (IRRadj) = 3.71, 95% confidence interval (CI): 1.57-8.77, P = 0.003). Daily intake of prenatal vitamins was not associated with cognition (IRRadj = 1.34, 95% CI: 0.73-2.46, P = 0.34). Upon stratification, the experience of mild-severe PPD with daily intake of prenatal vitamins was associated with higher incident rates of suboptimal cognition compared to children of women with daily prenatal vitamin intake without any episode of PPD (IRRadj = 2.88, 95% CI: 1.1-7.4). CONCLUSIONS: Moderate-severe PPD in early pregnancy is associated with poor cognition in children and daily intake of prenatal vitamin did not ameliorate this association. IMPACT: Our findings expand on existing literature by highlighting that exposure to prenatal psychological distress (PPD), in moderate-to-severe form, in the early stages of pregnancy, can have detrimental effects on the offspring's cognitive development at 4 years. Overall, prenatal vitamin intake did not ameliorate the effects of PPD. Early screening and treatment of prenatal maternal mental illness is crucial.
BACKGROUND: Maternal prenatal psychological distress (PPD) is increasingly linked to sub-optimal child neurodevelopment. Daily intake of prenatal vitamin during pre-conception and early pregnancy may ameliorate the effects of PPD on cognition in the offspring. METHODS: PPD was assessed in early (12-16 weeks) and late (28-32 weeks) gestation in the Ontario Birth Study. Prenatal vitamin supplement intake information was collected in early gestation. Child cognition at 4 years was assessed using the NIH Toolbox. Poisson regression was used to investigate associations between PPD and/or prenatal vitamin intake and child cognition. RESULTS: Four hundred and eighteen mother-child dyads were assessed. Moderate-severe PPD experienced during early gestation was associated with reduced cognition (adjusted incidence rate ratio (IRRadj) = 3.71, 95% confidence interval (CI): 1.57-8.77, P = 0.003). Daily intake of prenatal vitamins was not associated with cognition (IRRadj = 1.34, 95% CI: 0.73-2.46, P = 0.34). Upon stratification, the experience of mild-severe PPD with daily intake of prenatal vitamins was associated with higher incident rates of suboptimal cognition compared to children of women with daily prenatal vitamin intake without any episode of PPD (IRRadj = 2.88, 95% CI: 1.1-7.4). CONCLUSIONS: Moderate-severe PPD in early pregnancy is associated with poor cognition in children and daily intake of prenatal vitamin did not ameliorate this association. IMPACT: Our findings expand on existing literature by highlighting that exposure to prenatal psychological distress (PPD), in moderate-to-severe form, in the early stages of pregnancy, can have detrimental effects on the offspring's cognitive development at 4 years. Overall, prenatal vitamin intake did not ameliorate the effects of PPD. Early screening and treatment of prenatal maternal mental illness is crucial.
Authors: Lisa Underwood; Karen Waldie; Stephanie D'Souza; Elizabeth R Peterson; Susan Morton Journal: Arch Womens Ment Health Date: 2016-04-16 Impact factor: 3.633
Authors: Cathryn Gordon Green; Vanessa Babineau; Alexia Jolicoeur-Martineau; Andrée-Anne Bouvette-Turcot; Klaus Minde; Roberto Sassi; Martin St-André; Normand Carrey; Leslie Atkinson; James L Kennedy; Meir Steiner; John Lydon; Helene Gaudreau; Jacob A Burack; Robert Levitan; Michael J Meaney; Ashley Wazana Journal: Dev Psychopathol Date: 2016-07-18