Background: Since December 2019, (COVID-19) has had a significant impact on global health systems. Because little is known about the clinical characteristics and risk factors connected with COVID-19 severity in Sudanese patients, it is vital to summarize the clinical characteristics of COVID-19 patients and to investigate the risk factors linked to COVID-19 severity. Objectives: We aimed to assess the clinical characteristics of COVID-19 patients and look into risk factors associated with COVID-19 severity. Methods: This is a retrospective cross-sectional study that took place in two Isolation Centers in Wad Medani, Gezira State, Sudan. Four hundred and eighteen patients were included between May 2020 and May 2021. All COVID-19 patients over the age of 18 who were proven COVID-19 positive by nucleic acid testing or had characteristics suggestive of COVID-19 on a chest CT scan and had a complete medical record in the study period were included. Results: The participants in this study were 418 confirmed COVID-19 cases with a median age of 66.313 years. There were 279 men (66.7%) among the patients. The most prevalent comorbidities were hypertension (n = 195; 46.7%) and diabetes (n = 187; 44.7%). Fever (n = 303; 72.5%), cough (n = 278; 66.5%), and dyspnea (n = 256; 61.2%) were the most prevalent symptoms at the onset of COVID-19. The overall mortality rate (n = 148) was 35.4%. Patients with severe illness had a mortality rate of 42.3% (n = 118). Older age, anemia, neutrophilia, and lymphocytopenia, as well as higher glucose, HbA1c, and creatinine levels, were all linked to severe COVID-19, according to the chi-square test and analysis of variance analysis. Conclusion: Sixteen variables were found to be associated with COVID-19 severity. These patients are more prone to go through a serious infection and as a result have a greater death rate than those who do not have these characteristics.
Background: Since December 2019, (COVID-19) has had a significant impact on global health systems. Because little is known about the clinical characteristics and risk factors connected with COVID-19 severity in Sudanese patients, it is vital to summarize the clinical characteristics of COVID-19 patients and to investigate the risk factors linked to COVID-19 severity. Objectives: We aimed to assess the clinical characteristics of COVID-19 patients and look into risk factors associated with COVID-19 severity. Methods: This is a retrospective cross-sectional study that took place in two Isolation Centers in Wad Medani, Gezira State, Sudan. Four hundred and eighteen patients were included between May 2020 and May 2021. All COVID-19 patients over the age of 18 who were proven COVID-19 positive by nucleic acid testing or had characteristics suggestive of COVID-19 on a chest CT scan and had a complete medical record in the study period were included. Results: The participants in this study were 418 confirmed COVID-19 cases with a median age of 66.313 years. There were 279 men (66.7%) among the patients. The most prevalent comorbidities were hypertension (n = 195; 46.7%) and diabetes (n = 187; 44.7%). Fever (n = 303; 72.5%), cough (n = 278; 66.5%), and dyspnea (n = 256; 61.2%) were the most prevalent symptoms at the onset of COVID-19. The overall mortality rate (n = 148) was 35.4%. Patients with severe illness had a mortality rate of 42.3% (n = 118). Older age, anemia, neutrophilia, and lymphocytopenia, as well as higher glucose, HbA1c, and creatinine levels, were all linked to severe COVID-19, according to the chi-square test and analysis of variance analysis. Conclusion: Sixteen variables were found to be associated with COVID-19 severity. These patients are more prone to go through a serious infection and as a result have a greater death rate than those who do not have these characteristics.
Authors: Michael G Argenziano; Samuel L Bruce; Cody L Slater; Jonathan R Tiao; Matthew R Baldwin; R Graham Barr; Bernard P Chang; Katherine H Chau; Justin J Choi; Nicholas Gavin; Parag Goyal; Angela M Mills; Ashmi A Patel; Marie-Laure S Romney; Monika M Safford; Neil W Schluger; Soumitra Sengupta; Magdalena E Sobieszczyk; Jason E Zucker; Paul A Asadourian; Fletcher M Bell; Rebekah Boyd; Matthew F Cohen; MacAlistair I Colquhoun; Lucy A Colville; Joseph H de Jonge; Lyle B Dershowitz; Shirin A Dey; Katherine A Eiseman; Zachary P Girvin; Daniella T Goni; Amro A Harb; Nicholas Herzik; Sarah Householder; Lara E Karaaslan; Heather Lee; Evan Lieberman; Andrew Ling; Ree Lu; Arthur Y Shou; Alexander C Sisti; Zachary E Snow; Colin P Sperring; Yuqing Xiong; Henry W Zhou; Karthik Natarajan; George Hripcsak; Ruijun Chen Journal: BMJ Date: 2020-05-29
Authors: Runzhen Zhao; Zhenlei Su; Andrey A Komissarov; Shan-Lu Liu; Guohua Yi; Steven Idell; Michael A Matthay; Hong-Long Ji Journal: Front Immunol Date: 2021-05-07 Impact factor: 7.561
Authors: Basmah M Azad Allarakia; Hattan S Gattan; Rawan H Abdeen; Bassam M Al-Ahmadi; Abdullah F Shater; Mohammed B Bazaid; Omar W Althomali; Abdulrahman S Bazaid Journal: Dis Markers Date: 2022-05-26 Impact factor: 3.464