Literature DB >> 35282153

A Mathematical Model for early HBV and -HDV Kinetics during Anti-HDV Treatment.

Rami Zakh1, Alexander Churkin2, William Bietsch3, Menachem Lachiany4, Scott J Cotler3, Alexander Ploss5, Harel Dahari3, Danny Barash1.   

Abstract

Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.

Entities:  

Keywords:  HDV-HBV coinfection; hepatitis delta virus; viral kinetic models

Year:  2021        PMID： 35282153      PMCID： PMC8916717          DOI： 10.3390/math9243323

Source DB:  PubMed          Journal:  Mathematics (Basel)        ISSN： 2227-7390


  21 in total

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Journal:  J Hepatol       Date:  2003       Impact factor: 25.083

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Authors:  Wornei Silva Miranda Braga; Cintia Mara Costa de Oliveira; José Ribamar de Araújo; Marcia da Costa Castilho; Joelma Martins Rocha; Joao Bosco de Lima Gimaque; Maria Luana Cristiny Rodrigues Silva; Heline Lira Vasconcelos; Rajendranath Ramasawmy; Raymundo Paraná
Journal:  J Hepatol       Date:  2014-06-04       Impact factor: 25.083

3.  Hepatitis D infection: from initial discovery to current investigational therapies.

Authors:  Ben L Da; Theo Heller; Christopher Koh
Journal:  Gastroenterol Rep (Oxf)       Date:  2019-06-23

4.  Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. The European Concerted Action on Viral Hepatitis (Eurohep).

Authors:  G Fattovich; G Giustina; E Christensen; M Pantalena; I Zagni; G Realdi; S W Schalm
Journal:  Gut       Date:  2000-03       Impact factor: 23.059

5.  Numerical schemes for solving and optimizing multiscale models with age of hepatitis C virus dynamics.

Authors:  Vladimir Reinharz; Harel Dahari; Danny Barash
Journal:  Math Biosci       Date:  2018-03-15       Impact factor: 2.144

6.  Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling.

Authors:  Jeremie Guedj; Yaron Rotman; Scott J Cotler; Christopher Koh; Peter Schmid; Jeff Albrecht; Vanessa Haynes-Williams; T Jake Liang; Jay H Hoofnagle; Theo Heller; Harel Dahari
Journal:  Hepatology       Date:  2014-10-27       Impact factor: 17.425

7.  delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees.

Authors:  M Rizzetto; B Hoyer; M G Canese; J W Shih; R H Purcell; J L Gerin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

8.  Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric Mice.

Authors:  Vladimir Reinharz; Yuji Ishida; Masataka Tsuge; Karina Durso-Cain; Tje Lin Chung; Chise Tateno; Alan S Perelson; Susan L Uprichard; Kazuaki Chayama; Harel Dahari
Journal:  J Virol       Date:  2021-06-24       Impact factor: 5.103

9.  Early virological response in six patients with hepatitis D virus infection and compensated cirrhosis treated with Bulevirtide in real-life.

Authors:  Tarik Asselah; Dimitri Loureiro; Fréderic Le Gal; Stéphanie Narguet; Ségolène Brichler; Valérie Bouton; Malek Abazid; Nathalie Boyer; Nathalie Giuly; Athenais Gerber; Issam Tout; Sarah Maylin; Cheikh M Bed; Patrick Marcellin; Corinne Castelnau; Emmanuel Gordien; Abdellah Mansouri
Journal:  Liver Int       Date:  2021-06-08       Impact factor: 8.754

10.  Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg.

Authors:  Louis Shekhtman; Scott J Cotler; Leeor Hershkovich; Susan L Uprichard; Michel Bazinet; Victor Pantea; Valentin Cebotarescu; Lilia Cojuhari; Pavlina Jimbei; Adalbert Krawczyk; Ulf Dittmer; Andrew Vaillant; Harel Dahari
Journal:  Sci Rep       Date:  2020-05-12       Impact factor: 4.379
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