Hemender Singh1, Varun Sharma1,2, Indu Sharma1,2, Akash Sharma1, Sonakshi Modeel1, Nital Gupta3, Geetanjali Gupta4, Ajay K Pandita5, Mohammad Farooq Butt6, Rajesh Sharma7, Sarla Pandita8, Vinod Singh1, Ekta Rai1, Shiro Ikegawa9, Swarkar Sharma1. 1. Human Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University Katra, Jammu and Kashmir, India. 2. Ancient DNA laboratory, Birbal Sahni Institute of Palaeosciences Lucknow, Uttar Pradesh, India. 3. Department of Health and Family Welfare Union Territory, Jammu and Kashmir, India. 4. Department of Radiology, Shri Mata Vaishno Devi Narayana Superspeciality Hospital Katra, Jammu and Kashmir, India. 5. Accidental Hospital Chowki Choura, Jammu, Jammu and Kashmir, India. 6. Department of Orthopedics, Government Medical College Jammu, Jammu and Kashmir, India. 7. Department of Radio-Diagnosis, Government Medical College Jammu, Jammu and Kashmir, India. 8. Radiology Section, Chest Disease Hospital Bakshi Nagar, Jammu, Jammu and Kashmir, India. 9. Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences RIKEN, Tokyo, Japan.
Abstract
AIS is a heterogeneous 3D spinal deformity with Cobb angle ≥10°. It affects children in the age group of 10-16 years globally with 2-3% prevalence and significant female predominance. The exact etiology of AIS is not known however, it is supposed to be associated with factors such as anthropometric, metabolic, neuromuscular abnormalities and genetics. OBJECTIVES: To determine the prevalence of AIS and association of anthropometric factors with AIS in the studied population group. METHODOLOGY: Scoliosis screening of 9,500 individuals was carried out at different educational institutions of Jammu region in Jammu and Kashmir, India using a scoliosis-meter. The subjects were later examined radiologically. RESULTS: In population of the region, AIS was most prevalent among all types of scoliosis with overall prevalence of 0.61%. The prevalence was observed to be lower in females (0.31%) than males (0.88%). Based on angle of trunk rotation (ATR), lumbar curves were more prevalent than thoracic curves. Average Cobb angle in males and females were 24.9° and 22.6°, respectively. BMI showed significant association with AIS in the age group of 12-16 years (P value =0.028). Furthermore, height was significantly associated with AIS in the overall screened population (P-value =0.029). CONCLUSIONS: The AIS patients in the Jammu region of India have unique clinical features. In contrast to the global prevalence data, the prevalence of AIS in females in the region was less in comparison to males. Based on epidemiological literature and our findings, we hypothesized that genetic factors might be a major contributor in the AIS pathogenesis along with other confounding factors such as height, BMI, ethnicity, etc. AJTR
AIS is a heterogeneous 3D spinal deformity with Cobb angle ≥10°. It affects children in the age group of 10-16 years globally with 2-3% prevalence and significant female predominance. The exact etiology of AIS is not known however, it is supposed to be associated with factors such as anthropometric, metabolic, neuromuscular abnormalities and genetics. OBJECTIVES: To determine the prevalence of AIS and association of anthropometric factors with AIS in the studied population group. METHODOLOGY: Scoliosis screening of 9,500 individuals was carried out at different educational institutions of Jammu region in Jammu and Kashmir, India using a scoliosis-meter. The subjects were later examined radiologically. RESULTS: In population of the region, AIS was most prevalent among all types of scoliosis with overall prevalence of 0.61%. The prevalence was observed to be lower in females (0.31%) than males (0.88%). Based on angle of trunk rotation (ATR), lumbar curves were more prevalent than thoracic curves. Average Cobb angle in males and females were 24.9° and 22.6°, respectively. BMI showed significant association with AIS in the age group of 12-16 years (P value =0.028). Furthermore, height was significantly associated with AIS in the overall screened population (P-value =0.029). CONCLUSIONS: The AIS patients in the Jammu region of India have unique clinical features. In contrast to the global prevalence data, the prevalence of AIS in females in the region was less in comparison to males. Based on epidemiological literature and our findings, we hypothesized that genetic factors might be a major contributor in the AIS pathogenesis along with other confounding factors such as height, BMI, ethnicity, etc. AJTR
Authors: Swarkar Sharma; Douglas Londono; Walter L Eckalbar; Xiaochong Gao; Dongping Zhang; Kristen Mauldin; Ikuyo Kou; Atsushi Takahashi; Morio Matsumoto; Nobuhiro Kamiya; Karl K Murphy; Reuel Cornelia; John A Herring; Dennis Burns; Nadav Ahituv; Shiro Ikegawa; Derek Gordon; Carol A Wise Journal: Nat Commun Date: 2015-03-18 Impact factor: 14.919