Yongyan Cai1, Xiuli Wang2, Cuimin Li1, Fangfang Li1, Zhixin Yan1, Na Ma1, Mei Sun1. 1. Department of Pediatrics, Cangzhou Central Hospital Cangzhou 061000, Hebei Province, China. 2. Department of Clinical Laboratory, Cangzhou Central Hospital Cangzhou 061000, Hebei Province, China.
Abstract
OBJECTIVE: To investigate clinical effect of probiotics combined with zinc and selenium preparation in the treatment of child rotavirus enteritis. METHODS: In this retrospective study, the patients were divided into two groups based on treatment method. The control group (n=42) received probiotic therapy, while the experimental group (n=43) received probiotics combined with zinc and selenium preparation. Clinical efficacy, stool frequency and incidence of adverse reactions after treatment were compared to assess the clinical effect. RESULTS: The clinical effect was improved after intervention (P<0.05), and the total effective rate of two groups was 88.4% (38/43), 50% (21/42), respectively. Time to symptom disappearance was significantly decreased in the experimental group as compared to the control group. The myocardial zymogram indices (CK, CK-MB and AST) were decreased after treatment, and the levels in the experimental group were significantly lower than in the control group (P<0.05). Moreover, we observed that the levels of inflammatory factors (IL-6, IL-8 and hsCRP) in the experimental group were significantly lower than those of the control group after intervention (all P<0.05). CONCLUSION: Probiotics combined with zinc and selenium preparation can not only significantly improve the clinical effect, but also shorten the course of disease. AJTR
OBJECTIVE: To investigate clinical effect of probiotics combined with zinc and selenium preparation in the treatment of child rotavirus enteritis. METHODS: In this retrospective study, the patients were divided into two groups based on treatment method. The control group (n=42) received probiotic therapy, while the experimental group (n=43) received probiotics combined with zinc and selenium preparation. Clinical efficacy, stool frequency and incidence of adverse reactions after treatment were compared to assess the clinical effect. RESULTS: The clinical effect was improved after intervention (P<0.05), and the total effective rate of two groups was 88.4% (38/43), 50% (21/42), respectively. Time to symptom disappearance was significantly decreased in the experimental group as compared to the control group. The myocardial zymogram indices (CK, CK-MB and AST) were decreased after treatment, and the levels in the experimental group were significantly lower than in the control group (P<0.05). Moreover, we observed that the levels of inflammatory factors (IL-6, IL-8 and hsCRP) in the experimental group were significantly lower than those of the control group after intervention (all P<0.05). CONCLUSION: Probiotics combined with zinc and selenium preparation can not only significantly improve the clinical effect, but also shorten the course of disease. AJTR
Authors: Shailendra Singh; Rajendra Singh; K P Singh; V Singh; Y P S Malik; Bhupesh Kamdi; Rahul Singh; Gayatri Kashyap Journal: Microb Pathog Date: 2019-10-19 Impact factor: 3.738