Razieh Khalooeifard1, Jamal Rahmani2, Roozbeh Tavanaei3, Oladimeji Adebayo4, Mohsen Keykhaee3, Amirahmad Ahani3, Alireza Zali3, Zahra Vahdat Shariatpanahi5, Saeed Oraee-Yazdani6. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Community Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Shohada Tajrish Neurosurgical Center of Excellence, Functional Neurosurgery Research Center, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Department of Medicine, University College Hospital, Ibadan, Nigeria. 5. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Shohada Tajrish Neurosurgical Center of Excellence, Functional Neurosurgery Research Center, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Saeed_o_yazdani@sbmu.ac.ir.
Abstract
OBJECTIVES: Vitamin D plays a major role in bone metabolism, regulating calcium and phosphorus homeostasis, along with bone growth and remodeling processes. The objective of the present study was to assess the effect of vitamin D deficiency on clinical outcomes following elective spinal fusion surgery by conducting a meta-analysis on the relevant literature. METHODS: Studies included in this analysis involved patients older than 18 years who underwent elective spinal fusion surgery. The number of patients as well as visual analog scale (VAS) and Oswestry Disability Index (ODI) in groups with and without vitamin D deficiency were required to be reported in eligible studies. Of the 179 articles identified, 7 met the inclusion criteria and were included in the analysis. RESULTS: Seven studies, including 1188 patients, reported the relationship between vitamin D deficiency and clinical outcomes in patients undergoing elective spinal fusion surgery. Five studies reported VAS as a primary outcome. The combined results using a random-effects model showed reduction in VAS after elective spinal fusion surgery in group with vitamin D deficiency, but no statistically significant association was identified between vitamin D deficiency and VAS. ODI was assessed and reported as an outcome measure in 5 of the included studies. The combined results showed an increase in ODI following elective spinal fusion surgery in the vitamin D-deficient group compared to the group with normal levels of vitamin D. In addition, a significant association was observed between ODI and vitamin D deficiency. CONCLUSIONS: Vitamin D deficiency may negatively affect the postoperative outcomes in elective spinal fusion surgery. Preoperative optimization of vitamin D levels would seem appropriate. Future high-quality studies are highly warranted to evaluate this. CLINICAL RELEVANCE: This meta-analysis demonstrated a significant association between vitamin D deficiency and postoperative ODI scores in patients undergoing elective spinal fusion surgery. This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery.
OBJECTIVES: Vitamin D plays a major role in bone metabolism, regulating calcium and phosphorus homeostasis, along with bone growth and remodeling processes. The objective of the present study was to assess the effect of vitamin D deficiency on clinical outcomes following elective spinal fusion surgery by conducting a meta-analysis on the relevant literature. METHODS: Studies included in this analysis involved patients older than 18 years who underwent elective spinal fusion surgery. The number of patients as well as visual analog scale (VAS) and Oswestry Disability Index (ODI) in groups with and without vitamin D deficiency were required to be reported in eligible studies. Of the 179 articles identified, 7 met the inclusion criteria and were included in the analysis. RESULTS: Seven studies, including 1188 patients, reported the relationship between vitamin D deficiency and clinical outcomes in patients undergoing elective spinal fusion surgery. Five studies reported VAS as a primary outcome. The combined results using a random-effects model showed reduction in VAS after elective spinal fusion surgery in group with vitamin D deficiency, but no statistically significant association was identified between vitamin D deficiency and VAS. ODI was assessed and reported as an outcome measure in 5 of the included studies. The combined results showed an increase in ODI following elective spinal fusion surgery in the vitamin D-deficient group compared to the group with normal levels of vitamin D. In addition, a significant association was observed between ODI and vitamin D deficiency. CONCLUSIONS: Vitamin D deficiency may negatively affect the postoperative outcomes in elective spinal fusion surgery. Preoperative optimization of vitamin D levels would seem appropriate. Future high-quality studies are highly warranted to evaluate this. CLINICAL RELEVANCE: This meta-analysis demonstrated a significant association between vitamin D deficiency and postoperative ODI scores in patients undergoing elective spinal fusion surgery. This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery.
Authors: Vijay M Ravindra; Jian Guan; Christopher M Holland; Andrew T Dailey; Meic H Schmidt; Jakub Godzik; Robert S Hood; Wilson Z Ray; Erica F Bisson Journal: J Neurosurg Sci Date: 2016-09-02 Impact factor: 2.279
Authors: Varun Puvanesarajah; Francis H Shen; Jourdan M Cancienne; Wendy M Novicoff; Amit Jain; Adam L Shimer; Hamid Hassanzadeh Journal: J Neurosurg Spine Date: 2016-05-06
Authors: Vijay M Ravindra; Jakub Godzik; Andrew T Dailey; Meic H Schmidt; Erica F Bisson; Robert S Hood; Andrew Cutler; Wilson Z Ray Journal: Spine (Phila Pa 1976) Date: 2015-10-01 Impact factor: 3.468
Authors: Lars G Johnsen; Christian Hellum; Oystein P Nygaard; Kjersti Storheim; Jens I Brox; Ivar Rossvoll; Gunnar Leivseth; Margreth Grotle Journal: BMC Musculoskelet Disord Date: 2013-04-26 Impact factor: 2.362