Literature DB >> 3527158

The 20,000 dalton structural variant of recombinant DNA-derived methionyl human growth hormone has early insulin-like effects in hypophysectomized rats.

F C Tinsley, E L Grinnan, S H Baker, J G Powell, K G Bemis, C J Shaar.   

Abstract

The 20,000 dalton variant of recombinant DNA-derived methionyl human growth hormone (20K-Met-hGH) induced decreases in blood glucose and free fatty acid concentrations one hour after intraperitoneal injection into fasted, hypophysectomized rats. Similar results were obtained using the 22,000 dalton form of recombinant DNA-derived methionyl human growth hormone (22K-Met-hGH). The data reported show that 20K-Met-hGH induces early insulin-like effects similar to the responses produced by 22K-Met-hGH in fasted hypophysectomized rats.

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Year:  1986        PMID： 3527158     DOI： 10.1016/0006-291x(86)90286-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  Use of calcium dependence as a means to study the interaction between growth hormones and their binding proteins in rabbit liver.

Authors:  R Barnard; M J Waters
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

2.  Soluble forms of the rabbit adipose tissue and liver growth hormone receptors are antigenically identical, but the integral membrane forms differ.

Authors:  R Barnard; S W Rowlinson; M J Waters
Journal:  Biochem J       Date:  1990-04-15       Impact factor: 3.857

3.  Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans.

Authors:  Jenny Tong; David D'Alessio; Juliane Ramisch; Harold W Davis; Elizabeth Stambrook; Matthias H Tschöp; Martin Bidlingmaier
Journal:  J Clin Endocrinol Metab       Date:  2012-06-28       Impact factor: 5.958
  3 in total

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