| Literature DB >> 35271334 |
Luke Campagnola1, Stephanie C Seeman1, Thomas Chartrand1, Lisa Kim1, Alex Hoggarth1, Clare Gamlin1, Shinya Ito1, Jessica Trinh1, Pasha Davoudian1, Cristina Radaelli1, Mean-Hwan Kim1, Travis Hage1, Thomas Braun2, Lauren Alfiler1, Julia Andrade1, Phillip Bohn1, Rachel Dalley1, Alex Henry1, Sara Kebede1, Mukora Alice1, David Sandman1, Grace Williams1, Rachael Larsen1, Corinne Teeter1, Tanya L Daigle1, Kyla Berry1, Nadia Dotson1, Rachel Enstrom1, Melissa Gorham1, Madie Hupp1, Samuel Dingman Lee1, Kiet Ngo1, Philip R Nicovich1, Lydia Potekhina1, Shea Ransford1, Amanda Gary1, Jeff Goldy1, Delissa McMillen1, Trangthanh Pham1, Michael Tieu1, La'Akea Siverts1, Miranda Walker1, Colin Farrell1, Martin Schroedter1, Cliff Slaughterbeck1, Charles Cobb3, Richard Ellenbogen4, Ryder P Gwinn5, C Dirk Keene6, Andrew L Ko4,7, Jeffrey G Ojemann4,7, Daniel L Silbergeld4, Daniel Carey1, Tamara Casper1, Kirsten Crichton1, Michael Clark1, Nick Dee1, Lauren Ellingwood1, Jessica Gloe1, Matthew Kroll1, Josef Sulc1, Herman Tung1, Katherine Wadhwani1, Krissy Brouner1, Tom Egdorf1, Michelle Maxwell1, Medea McGraw1, Christina Alice Pom1, Augustin Ruiz1, Jasmine Bomben1, David Feng1, Nika Hejazinia1, Shu Shi1, Aaron Szafer1, Wayne Wakeman1, John Phillips1, Amy Bernard1, Luke Esposito1, Florence D D'Orazi1, Susan Sunkin1, Kimberly Smith1, Bosiljka Tasic1, Anton Arkhipov1, Staci Sorensen1, Ed Lein1, Christof Koch1, Gabe Murphy1, Hongkui Zeng1, Tim Jarsky1.
Abstract
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.Entities:
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Year: 2022 PMID： 35271334 DOI： 10.1126/science.abj5861
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714