Literature DB >> 35266825

Relationship between Resistance to Ethambutol and Rifampin and Clinical Outcomes in Mycobacterium avium Complex Pulmonary Disease.

Seong Mi Moon1, Su-Young Kim2, Dae Hun Kim2, Hee Jae Huh3, Nam Yong Lee3, Byung Woo Jhun2.   

Abstract

We evaluated the associations between the in vitro activities of ethambutol and rifampin and clinical outcomes of Mycobacterium avium complex (MAC) pulmonary disease (PD). Among 158 patients with MAC-PD, there was no relationship between high MICs for ethambutol and/or rifampin and treatment failure for MAC-PD. Ethambutol and rifampin resistance was common among MAC isolates (rates of 87% and 59%, respectively), but mutations in embB, rpoB, and rpoC were rare, with detection in only 4% of the drug-resistant MAC isolates.

Entities:  

Keywords:  MIC; Mycobacterium avium complex; ethambutol; outcome; rifampin

Mesh：

Substances：

Year:  2022        PMID： 35266825      PMCID： PMC9017369          DOI： 10.1128/aac.02027-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  31 in total

1.  Relationship between clinical efficacy of treatment of pulmonary Mycobacterium avium complex disease and drug-sensitivity testing of Mycobacterium avium complex isolates.

Authors:  Yoshihiro Kobashi; Kouichiro Yoshida; Naoyuki Miyashita; Yoshihito Niki; Mikio Oka
Journal:  J Infect Chemother       Date:  2006-08       Impact factor: 2.211

2.  Prognostic factors associated with long-term mortality in 1445 patients with nontuberculous mycobacterial pulmonary disease: a 15-year follow-up study.

Authors:  Byung Woo Jhun; Seong Mi Moon; Kyeongman Jeon; O Jung Kwon; Heejin Yoo; Keumhee C Carriere; Hee Jae Huh; Nam Yong Lee; Sung Jae Shin; Charles L Daley; Won-Jung Koh
Journal:  Eur Respir J       Date:  2020-01-02       Impact factor: 16.671

3.  The absence of genetic markers for streptomycin and rifampicin resistance in Mycobacterium avium complex strains.

Authors:  L Portillo-Gomez; J Nair; D A Rouse; S L Morris
Journal:  J Antimicrob Chemother       Date:  1995-12       Impact factor: 5.790

4.  Evaluation of the rpoB gene in rifampicin-susceptible and -resistant Mycobacterium avium and Mycobacterium intracellulare.

Authors:  C Guerrero; L Stockman; F Marchesi; T Bodmer; G D Roberts; A Telenti
Journal:  J Antimicrob Chemother       Date:  1994-03       Impact factor: 5.790

5.  Effect of ethambutol on emergence of clarithromycin-resistant Mycobacterium avium complex in the beige mouse model.

Authors:  L E Bermudez; K A Nash; M Petrofsky; L S Young; C B Inderlied
Journal:  J Infect Dis       Date:  1996-12       Impact factor: 5.226

Review 6.  Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review.

Authors:  D Rebecca Prevots; Theodore K Marras
Journal:  Clin Chest Med       Date:  2014-11-06       Impact factor: 2.878

7.  Pulmonary disease caused by Mycobacterium avium-intracellulare in HIV-negative patients: five-year follow-up of patients receiving standardised treatment.

Authors: 
Journal:  Int J Tuberc Lung Dis       Date:  2002-07       Impact factor: 2.373

8.  Putative compensatory mutations in the rpoC gene of rifampin-resistant Mycobacterium tuberculosis are associated with ongoing transmission.

Authors:  M de Vos; B Müller; S Borrell; P A Black; P D van Helden; R M Warren; S Gagneux; T C Victor
Journal:  Antimicrob Agents Chemother       Date:  2012-12-03       Impact factor: 5.191

9.  Characterization of rifampin-resistance in pathogenic mycobacteria.

Authors:  D L Williams; C Waguespack; K Eisenach; J T Crawford; F Portaels; M Salfinger; C M Nolan; C Abe; V Sticht-Groh; T P Gillis
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

10.  Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

Authors:  Francesc Coll; Jody Phelan; Grant A Hill-Cawthorne; Mridul B Nair; Kim Mallard; Shahjahan Ali; Abdallah M Abdallah; Saad Alghamdi; Mona Alsomali; Abdallah O Ahmed; Stephanie Portelli; Yaa Oppong; Adriana Alves; Theolis Barbosa Bessa; Susana Campino; Maxine Caws; Anirvan Chatterjee; Amelia C Crampin; Keertan Dheda; Nicholas Furnham; Judith R Glynn; Louis Grandjean; Dang Minh Ha; Rumina Hasan; Zahra Hasan; Martin L Hibberd; Moses Joloba; Edward C Jones-López; Tomoshige Matsumoto; Anabela Miranda; David J Moore; Nora Mocillo; Stefan Panaiotov; Julian Parkhill; Carlos Penha; João Perdigão; Isabel Portugal; Zineb Rchiad; Jaime Robledo; Patricia Sheen; Nashwa Talaat Shesha; Frik A Sirgel; Christophe Sola; Erivelton Oliveira Sousa; Elizabeth M Streicher; Paul Van Helden; Miguel Viveiros; Robert M Warren; Ruth McNerney; Arnab Pain; Taane G Clark
Journal:  Nat Genet       Date:  2018-01-22       Impact factor: 38.330
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