Matthew R LeBlanc1, Ashley Leak Bryant2, Thomas W LeBlanc3,4, Qing Yang5, Emily Sellars3, Cristiana Costa Chase3, Sophia K Smith4,5. 1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel, Hill 101 Manning Drive, , Chapel Hill, NC, 27514, USA. matthew_leblanc@unc.edu. 2. University of North Carolina at Chapel Hill School of Nursing, Chapel Hill, USA. 3. Duke University School of Medicine, Durham, USA. 4. Duke Cancer Institute, Durham, USA. 5. Duke University School of Nursing, Durham, USA.
Abstract
BACKGROUND: The purpose of this manuscript is to describe health-related quality of life (HRQoL) outcomes in a United States (US)-based sample of multiple myeloma (MM) patients and identify characteristics associated with poor HRQoL. PATIENTS AND METHODS: MM patients identified through the Tumor Registry of a Southeastern US medical center were mailed surveys assessing patient characteristics and HRQoL outcomes. HRQoL outcomes were measured using PROMIS short form instruments which included measures of global health (global physical health and global mental health), physical function, and ability to participate in social roles and activities (social function). HRQoL domain scores were summarized, and best subset linear regression was used to identify predictors of HRQoL. RESULTS: A total of 690 patients completed and returned surveys for a response rate of 64.7%. Respondents reported global physical health (44.9), global mental health (47.5), and physical function (44.1) significantly worse than the general population mean of 50 (p < .0001). Social function (49.5) did not differ significantly (p = .09). Worse socioeconomic status, higher comorbidities, not being in remission, and past receipt of radiation therapy were significantly associated with worse HRQoL. Treatment status and time since diagnosis were not associated with HRQoL outcomes. CONCLUSIONS: Patients with MM have significantly worse HRQoL than the general population. These findings warrant increased attention from clinicians and researchers. More research is needed to better describe the relationship between treatment patterns and HRQoL in patients with MM, and to identify effective interventions.
BACKGROUND: The purpose of this manuscript is to describe health-related quality of life (HRQoL) outcomes in a United States (US)-based sample of multiple myeloma (MM) patients and identify characteristics associated with poor HRQoL. PATIENTS AND METHODS: MM patients identified through the Tumor Registry of a Southeastern US medical center were mailed surveys assessing patient characteristics and HRQoL outcomes. HRQoL outcomes were measured using PROMIS short form instruments which included measures of global health (global physical health and global mental health), physical function, and ability to participate in social roles and activities (social function). HRQoL domain scores were summarized, and best subset linear regression was used to identify predictors of HRQoL. RESULTS: A total of 690 patients completed and returned surveys for a response rate of 64.7%. Respondents reported global physical health (44.9), global mental health (47.5), and physical function (44.1) significantly worse than the general population mean of 50 (p < .0001). Social function (49.5) did not differ significantly (p = .09). Worse socioeconomic status, higher comorbidities, not being in remission, and past receipt of radiation therapy were significantly associated with worse HRQoL. Treatment status and time since diagnosis were not associated with HRQoL outcomes. CONCLUSIONS: Patients with MM have significantly worse HRQoL than the general population. These findings warrant increased attention from clinicians and researchers. More research is needed to better describe the relationship between treatment patterns and HRQoL in patients with MM, and to identify effective interventions.
Authors: Honghu Liu; David Cella; Richard Gershon; Jie Shen; Leo S Morales; William Riley; Ron D Hays Journal: J Clin Epidemiol Date: 2010-08-05 Impact factor: 6.437
Authors: Elizabeth A Hahn; Robert F Devellis; Rita K Bode; Sofia F Garcia; Liana D Castel; Susan V Eisen; Hayden B Bosworth; Allen W Heinemann; Nan Rothrock; David Cella Journal: Qual Life Res Date: 2010-04-25 Impact factor: 4.147
Authors: Ethan Basch; Angela M Stover; Deborah Schrag; Arlene Chung; Jennifer Jansen; Sydney Henson; Philip Carr; Brenda Ginos; Allison Deal; Patricia A Spears; Mattias Jonsson; Antonia V Bennett; Gita Mody; Gita Thanarajasingam; Lauren J Rogak; Bryce B Reeve; Claire Snyder; Lisa A Kottschade; Marjory Charlot; Anna Weiss; Deborah Bruner; Amylou C Dueck Journal: JCO Clin Cancer Inform Date: 2020-10
Authors: Karin Jordan; Irina Proskorovsky; Philip Lewis; Jack Ishak; Krista Payne; Noreen Lordan; Charalampia Kyriakou; Cathy D Williams; Sarah Peters; Faith E Davies Journal: Support Care Cancer Date: 2014-02 Impact factor: 3.603
Authors: Sikander Ailawadhi; Sundar Jagannath; Mohit Narang; Robert M Rifkin; Howard R Terebelo; Kathleen Toomey; Brian G M Durie; James W Hardin; Cristina J Gasparetto; Lynne Wagner; James L Omel; Vivek Kumar; Lihua Yue; Amani Kitali; Amit Agarwal; Rafat Abonour Journal: Cancer Med Date: 2019-11-07 Impact factor: 4.452
Authors: Christina Ramsenthaler; Thomas R Osborne; Wei Gao; Richard J Siegert; Polly M Edmonds; Stephen A Schey; Irene J Higginson Journal: BMC Cancer Date: 2016-07-07 Impact factor: 4.430