Arpan Haldar1, Kaushik Sadhukhan2, Subhrajyoti Naskar3. 1. Department of Anatomy, AIIMS DEOGHAR, India. 2. Department of Ophthalmology, AIIMS PATNA, India. 3. Department of Community Medicine, Diamond Harbour Government Medical College, West Bengal, India.
Abstract
Aim: To study the ultrastructural, histochemical, cytological features of retina in aborted fetuses of different gestational age and its probable implication in the disease process of retinitis pigmentosa. Methodology: This is a prospective randomized cross sectional study that has been carried out in AIIMS Bhubaneswar from June 2017 to May 2019, jointly by the Department of Anatomy and Obstetrics and Gynaecology, AIIMS, Bhubaneswar, India, after proper institutional approval. Three fetuses from each trimester were taken into the present study; their retina was collected and subsequently sent for cytological, immunohistochemical and ultrastructural explorations. Detailed information from all explorations were collected and properly documented. Results: Fetuses whose retinas that have been shown to contain very few to no rod cells and short-sized cone cells might tend to develop retinitis pigmentosa after birth. Moreover, those cone cells have been shown to contain melanolysosome, phagosomes, autophagic vacuoles, and membranous whorls.
Aim: To study the ultrastructural, histochemical, cytological features of retina in aborted fetuses of different gestational age and its probable implication in the disease process of retinitis pigmentosa. Methodology: This is a prospective randomized cross sectional study that has been carried out in AIIMS Bhubaneswar from June 2017 to May 2019, jointly by the Department of Anatomy and Obstetrics and Gynaecology, AIIMS, Bhubaneswar, India, after proper institutional approval. Three fetuses from each trimester were taken into the present study; their retina was collected and subsequently sent for cytological, immunohistochemical and ultrastructural explorations. Detailed information from all explorations were collected and properly documented. Results: Fetuses whose retinas that have been shown to contain very few to no rod cells and short-sized cone cells might tend to develop retinitis pigmentosa after birth. Moreover, those cone cells have been shown to contain melanolysosome, phagosomes, autophagic vacuoles, and membranous whorls.
Authors: D A Bessant; A M Payne; K P Mitton; Q L Wang; P K Swain; C Plant; A C Bird; D J Zack; A Swaroop; S S Bhattacharya Journal: Nat Genet Date: 1999-04 Impact factor: 38.330
Authors: P Banerjee; P W Kleyn; J A Knowles; C A Lewis; B M Ross; E Parano; S G Kovats; J J Lee; G K Penchaszadeh; J Ott; S G Jacobson; T C Gilliam Journal: Nat Genet Date: 1998-02 Impact factor: 38.330