BACKGROUND: Despite the importance of immune response and environmental stress on head and neck cancer (HNC) outcomes, no current pre-clinical stress model includes a humanized immune system. METHODS: We investigated the effects of chronic stress induced by social isolation on tumor growth and human immune response in subcutaneous HNC tumors grown in NSG-SGM3 mice engrafted with a human immune system. RESULTS: Tumor growth (p < 0.0001) and lung metastases (p = 0.035) were increased in socially isolated versus control animals. Chronic stress increased intra-tumoral CD4+ T-cell infiltrate (p = 0.005), plasma SDF-1 (p < 0.0001) expression, and led to tumor cell dedifferentiation toward a cancer stem cell phenotype (CD44+ /ALDHhigh , p = 0.025). CONCLUSIONS: Chronic stress induced immunophenotypic changes, increased tumor growth, and metastasis in HNC in a murine model with a humanized immune system. This model system may provide further insight into the immunologic and oncologic impact of chronic stress on patients with HNC.
BACKGROUND: Despite the importance of immune response and environmental stress on head and neck cancer (HNC) outcomes, no current pre-clinical stress model includes a humanized immune system. METHODS: We investigated the effects of chronic stress induced by social isolation on tumor growth and human immune response in subcutaneous HNC tumors grown in NSG-SGM3 mice engrafted with a human immune system. RESULTS: Tumor growth (p < 0.0001) and lung metastases (p = 0.035) were increased in socially isolated versus control animals. Chronic stress increased intra-tumoral CD4+ T-cell infiltrate (p = 0.005), plasma SDF-1 (p < 0.0001) expression, and led to tumor cell dedifferentiation toward a cancer stem cell phenotype (CD44+ /ALDHhigh , p = 0.025). CONCLUSIONS: Chronic stress induced immunophenotypic changes, increased tumor growth, and metastasis in HNC in a murine model with a humanized immune system. This model system may provide further insight into the immunologic and oncologic impact of chronic stress on patients with HNC.
Authors: Steven W Cole; Jesusa M G Arevalo; Rie Takahashi; Erica K Sloan; Susan K Lutgendorf; Anil K Sood; John F Sheridan; Teresa E Seeman Journal: Proc Natl Acad Sci U S A Date: 2010-02-22 Impact factor: 11.205
Authors: Jennifer M Knight; J Douglas Rizzo; Brent R Logan; Tao Wang; Jesusa M G Arevalo; Jeffrey Ma; Steve W Cole Journal: Clin Cancer Res Date: 2015-08-18 Impact factor: 12.531
Authors: Caroline P Le; Cameron J Nowell; Corina Kim-Fuchs; Edoardo Botteri; Jonathan G Hiller; Hilmy Ismail; Matthew A Pimentel; Ming G Chai; Tara Karnezis; Nicole Rotmensz; Giuseppe Renne; Sara Gandini; Colin W Pouton; Davide Ferrari; Andreas Möller; Steven A Stacker; Erica K Sloan Journal: Nat Commun Date: 2016-03-01 Impact factor: 14.919
Authors: Jennifer M Knight; J Douglas Rizzo; Tao Wang; Naya He; Brent R Logan; Stephen R Spellman; Stephanie J Lee; Michael R Verneris; Jesusa M G Arevalo; Steve W Cole Journal: JNCI Cancer Spectr Date: 2019-09-12