Hongyu Du1,2, Jie Xia1, Jie Fan1, Feng Gao1, Xiang Wang1, Yan Han1, Changlian Tan3, Xiongzhao Zhu4,5,6. 1. Medical Psychological Center, the Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People's Republic of China. 2. Medical Psychological Institute of Central South University, Changsha, Hunan, 410011, People's Republic of China. 3. Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. 4. Medical Psychological Center, the Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People's Republic of China. xiongzhaozhu@csu.edu.cn. 5. Medical Psychological Institute of Central South University, Changsha, Hunan, 410011, People's Republic of China. xiongzhaozhu@csu.edu.cn. 6. National Clinical Research Center for Mental Disorders, Changsha, Hunan, 410011, People's Republic of China. xiongzhaozhu@csu.edu.cn.
Abstract
BACKGROUND: Accumulating evidence indicated that anhedonia as a transdiagnostic construct might be an inherent feature of obsessive-compulsive disorder(OCD). Moreover, our recent study demonstrated that OCD patients exhibited consummatory anhedonia but not anticipatory anhedonia. However, neural mechanisms of consummatory anhedonia in OCD has not been explored. This study aimed to investigate this issue using resting-state functional magnetic resonance imaging (fMRI). METHODS: 44 OCD patients with high consummatory anhedonia(OCD-HCA), 41 OCD patients with low consummatory anhedonia(OCD-LCA) and 47 healthy controls (HC) underwent fMRI scan. Spontaneous neural activity was analyzed and compared among the three groups by adopting the amplitude of low-frequency fluctuation (ALFF). Relationships between the consummatory anhedonia levels and regional ALFFs were examined in OCD patients. RESULTS: Compared with HC, OCD-HCA showed decreased ALFF in the right putamen and right thalamus, and OCD-LCA showed increased ALFF in the right orbitofrontal cortex and decreased ALFF in the right fusiform gyrus, left Precentral/postcentral gyrus. Notably, ALFF values differed between the two patient groups in the right putamen (OCD-HCA < OCD-LCA), and right fusiform gyrus (OCD-HCA > OCD-LCA). Further analysis revealed that the consummatory anhedonia was positively correlated with ALFF values in the right fusiform, and negatively correlated with ALFFs in the right putamen. CONCLUSIONS: Spontaneous neural activity in right fusiform gyrus and right putamen is associated with consummatory anhedonia in OCD. The findings provided first insights into neural mechanism of consummatory anhedonia in OCD and confirmed the importance of exploring the transdiagnostic role of anhedonia.
BACKGROUND: Accumulating evidence indicated that anhedonia as a transdiagnostic construct might be an inherent feature of obsessive-compulsive disorder(OCD). Moreover, our recent study demonstrated that OCD patients exhibited consummatory anhedonia but not anticipatory anhedonia. However, neural mechanisms of consummatory anhedonia in OCD has not been explored. This study aimed to investigate this issue using resting-state functional magnetic resonance imaging (fMRI). METHODS: 44 OCD patients with high consummatory anhedonia(OCD-HCA), 41 OCD patients with low consummatory anhedonia(OCD-LCA) and 47 healthy controls (HC) underwent fMRI scan. Spontaneous neural activity was analyzed and compared among the three groups by adopting the amplitude of low-frequency fluctuation (ALFF). Relationships between the consummatory anhedonia levels and regional ALFFs were examined in OCD patients. RESULTS: Compared with HC, OCD-HCA showed decreased ALFF in the right putamen and right thalamus, and OCD-LCA showed increased ALFF in the right orbitofrontal cortex and decreased ALFF in the right fusiform gyrus, left Precentral/postcentral gyrus. Notably, ALFF values differed between the two patient groups in the right putamen (OCD-HCA < OCD-LCA), and right fusiform gyrus (OCD-HCA > OCD-LCA). Further analysis revealed that the consummatory anhedonia was positively correlated with ALFF values in the right fusiform, and negatively correlated with ALFFs in the right putamen. CONCLUSIONS: Spontaneous neural activity in right fusiform gyrus and right putamen is associated with consummatory anhedonia in OCD. The findings provided first insights into neural mechanism of consummatory anhedonia in OCD and confirmed the importance of exploring the transdiagnostic role of anhedonia.
Authors: Heather A Berlin; Kurt P Schulz; Sam Zhang; Rachel Turetzky; David Rosenthal; Wayne Goodman Journal: Psychiatry Res Date: 2015-09-30 Impact factor: 3.222