| Literature DB >> 35255205 |
Hubert Santuz1, Phuong H Nguyen1, Fabio Sterpone1, Philippe Derreumaux1,2.
Abstract
Aggregation of amyloid-β (Aβ42) protein is one hallmark of Alzheimer's disease, and the conformations of the smallest Aβ42 oligomers are largely unknown. Here, we explore the application of the deep learning AlphaFold2 method to the structure determination of Aβ42 monomers up to hexamers. The results shed light on the early Aβ42 aggregation steps in the bulk solution.Entities:
Keywords: AlphaFold2; Alzheimer’s disease; Amyloid-β; monomers and small oligomers; simulations
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Year: 2022 PMID： 35255205 DOI： 10.1021/acschemneuro.2c00122
Source DB: PubMed Journal: ACS Chem Neurosci ISSN： 1948-7193 Impact factor: 4.418