Literature DB >> 35250397

Are Antiviral Flavonoids Part of the Solution to the COVID-19 Pandemic?

Joseph Pizzorno.   

Abstract

The relentless continuation of the COVID-19 (coronavirus disease 2019) pandemic clearly indicates the need to broaden our approach to this serious, worldwide problem. An important factor that has received little attention is the protective role of dietary antiviral flavonoids. Many flavonoids have been shown through molecular docking assays, as well as in silico studies, and in vitro and in vivo studies to inhibit virtually every mechanism needed by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) to penetrate cells and hijack molecular processes. These inhibitory effects have shown clinical benefit in a few preliminary studies. In this editorial I present research which makes the case for dietary flavonoids as part of the solution to the COVID-19 pandemic.
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Entities:  

Year:  2021        PMID: 35250397      PMCID: PMC8887228     

Source DB:  PubMed          Journal:  Integr Med (Encinitas)        ISSN: 1546-993X


  41 in total

1.  Screening of potential bio-molecules from Moringa olifera against SARS-CoV-2 main protease using computational approaches.

Authors:  Shalini Mathpal; Priyanka Sharma; Tushar Joshi; Tanuja Joshi; Veena Pande; Subhash Chandra
Journal:  J Biomol Struct Dyn       Date:  2021-06-21

2.  Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation.

Authors:  R R Ortiz-Andrade; J C Sánchez-Salgado; G Navarrete-Vázquez; S P Webster; M Binnie; S García-Jiménez; I León-Rivera; P Cigarroa-Vázquez; R Villalobos-Molina; S Estrada-Soto
Journal:  Diabetes Obes Metab       Date:  2008-03-18       Impact factor: 6.577

3.  Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.

Authors:  Kanchan Anand; John Ziebuhr; Parvesh Wadhwani; Jeroen R Mesters; Rolf Hilgenfeld
Journal:  Science       Date:  2003-05-13       Impact factor: 47.728

4.  The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake.

Authors:  Jie Cao; Ying Zhang; Wei Chen; Xiujuan Zhao
Journal:  Br J Nutr       Date:  2009-09-14       Impact factor: 3.718

5.  Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro.

Authors:  Hongbo Liu; Fei Ye; Qi Sun; Hao Liang; Chunmei Li; Siyang Li; Roujian Lu; Baoying Huang; Wenjie Tan; Luhua Lai
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

6.  Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain.

Authors:  Seokho Hong; Sang Hwan Seo; Sun-Je Woo; Yonghoon Kwon; Manki Song; Nam-Chul Ha
Journal:  J Agric Food Chem       Date:  2021-05-21       Impact factor: 5.279

7.  Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study.

Authors:  Francesco Di Pierro; Giuseppe Derosa; Pamela Maffioli; Alexander Bertuccioli; Stefano Togni; Antonella Riva; Pietro Allegrini; Amjad Khan; Saeed Khan; Bilal Ahmad Khan; Naireen Altaf; Maria Zahid; Ikram Din Ujjan; Roohi Nigar; Mehwish Imam Khushk; Maryam Phulpoto; Amanullah Lail; Bikha Ram Devrajani; Sagheer Ahmed
Journal:  Int J Gen Med       Date:  2021-06-08

8.  Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2.

Authors:  Ahmed Kandeil; Ahmed Mostafa; Omnia Kutkat; Yassmin Moatasim; Ahmed A Al-Karmalawy; Adel A Rashad; Ahmed E Kayed; Azza E Kayed; Rabeh El-Shesheny; Ghazi Kayali; Mohamed A Ali
Journal:  Pathogens       Date:  2021-06-15

9.  Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach.

Authors:  Luis Daniel Goyzueta-Mamani; Haruna Luz Barazorda-Ccahuana; Karel Mena-Ulecia; Miguel Angel Chávez-Fumagalli
Journal:  Molecules       Date:  2021-06-25       Impact factor: 4.411

10.  Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches.

Authors:  Hossam M Abdallah; Ali M El-Halawany; Alaa Sirwi; Amr M El-Araby; Gamal A Mohamed; Sabrin R M Ibrahim; Abdulrahman E Koshak; Hani Z Asfour; Zuhier A Awan; Mahmoud A Elfaky
Journal:  Pharmaceuticals (Basel)       Date:  2021-03-04
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