Literature DB >> 35250074

Effect of polymer addition on the physical properties of freeze-dried soup solid.

Tomochika Sogabe1, Koichi Ohira2, Kiyoshi Kawai1.   

Abstract

The effect of polymers (gelatin, starch, and maltodextrin) on the physical properties of freeze-dried model soup (sodium chloride, sucrose, and monosodium glutamate) was investigated. The polymers were added to the soup solution at 1 or 3% (w/v), which was then freeze-dried at 25 or 50 °C. Gelatin and maltodextrin prevented crystallization of sodium chloride to a greater extent than starch under freezing. Freeze-drying was conducted above the freeze-concentrated glass transition temperature. Polymer addition prolonged drying time, but prevented structural deformation. Gelatin enhanced the physical strength of the freeze-dried solid more than starch and maltodextrin because of its gel-network. In a dissolution test, 1% gelatin, and 1 and 3% maltodextrin exhibited greater dissolution than the other samples. The drying rate was lower at 50 °C, with minor modifications to the other properties. From these results, it was concluded that 1% gelatin was useful as a physical stabilizer for freeze-dried soup. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13197-021-05161-x. © Association of Food Scientists & Technologists (India) 2021.

Entities:  

Keywords:  Collapse; Drying rate; Freeze-concentrated glass transition; Freeze-drying; Gelatin

Year:  2021        PMID: 35250074      PMCID: PMC8882557          DOI: 10.1007/s13197-021-05161-x

Source DB:  PubMed          Journal:  J Food Sci Technol        ISSN: 0022-1155            Impact factor:   2.701


  12 in total

Review 1.  Lyophilization and development of solid protein pharmaceuticals.

Authors:  W Wang
Journal:  Int J Pharm       Date:  2000-08-10       Impact factor: 5.875

Review 2.  Design of freeze-drying processes for pharmaceuticals: practical advice.

Authors:  Xiaolin Tang; Michael J Pikal
Journal:  Pharm Res       Date:  2004-02       Impact factor: 4.200

3.  The role of formulation excipients in the development of lyophilised fast-disintegrating tablets.

Authors:  Rahul Chandrasekhar; Zahra Hassan; Farhan Alhusban; Alan M Smith; Afzal R Mohammed
Journal:  Eur J Pharm Biopharm       Date:  2008-12-03       Impact factor: 5.571

4.  Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method.

Authors:  X Wu; Y Liu; X Li; P Wen; Y Zhang; Y Long; X Wang; Y Guo; F Xing; J Gao
Journal:  Acta Biomater       Date:  2009-09-04       Impact factor: 8.947

Review 5.  The freezing step in lyophilization: physico-chemical fundamentals, freezing methods and consequences on process performance and quality attributes of biopharmaceuticals.

Authors:  Julia Christina Kasper; Wolfgang Friess
Journal:  Eur J Pharm Biopharm       Date:  2011-03-21       Impact factor: 5.571

6.  Use of a soft sensor for the fast estimation of dried cake resistance during a freeze-drying cycle.

Authors:  Serena Bosca; Antonello A Barresi; Davide Fissore
Journal:  Int J Pharm       Date:  2013-04-25       Impact factor: 5.875

7.  Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations.

Authors:  Christina Haeuser; Pierre Goldbach; Joerg Huwyler; Wolfgang Friess; Andrea Allmendinger
Journal:  Eur J Pharm Biopharm       Date:  2019-12-19       Impact factor: 5.571

Review 8.  Excipients in freeze-dried biopharmaceuticals: Contributions toward formulation stability and lyophilisation cycle optimisation.

Authors:  Maja Bjelošević; Alenka Zvonar Pobirk; Odon Planinšek; Pegi Ahlin Grabnar
Journal:  Int J Pharm       Date:  2020-01-15       Impact factor: 5.875

9.  Vial breakage during freeze-drying: crystallization of sodium chloride in sodium chloride-sucrose frozen aqueous solutions.

Authors:  N Milton; G Gopalrathnam; G D Craig; D S Mishra; M L Roy; L Yu
Journal:  J Pharm Sci       Date:  2007-07       Impact factor: 3.534

10.  Freeze-drying of mannitol-trehalose-sodium chloride-based formulations: the impact of annealing on dry layer resistance to mass transfer and cake structure.

Authors:  Xiaofeng Lu; Michael J Pikal
Journal:  Pharm Dev Technol       Date:  2004       Impact factor: 3.133

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