Literature DB >> 35248130

Correction to: Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting.

Ryan P Cheng1, Puneet Dang1, Alemji A Taku1, Yoon Ji Moon1, Vi Pham1, Xiaohe Sun1, Ethan Zhao1, Jonathan A Raper2.   

Abstract

Entities:  

Year:  2022        PMID: 35248130      PMCID: PMC8898399          DOI: 10.1186/s13064-022-00160-w

Source DB:  PubMed          Journal:  Neural Dev        ISSN: 1749-8104            Impact factor:   3.842


× No keyword cloud information.
Correction to: Neural Dev 17, 1 (2022) 10.1186/s13064-021-00157-x Following publication of the original article [1], the last two figures in the paper were misordered during the publication process and references to one of the figures were omitted. The figure entitled “Both nrp2a and nrp2b act in the same pathway with sema3fa” formerly appeared as Fig. 6 and now appears correctly as Fig. 5. The figure entitled “Misprojecting growth cones fail to retract in nrp2a and in sema3fa mutants” formerly appeared as Fig. 5 and now appears as Fig. 6. The correct figures are given below. Text referring to the corrected Fig. 5 was amended to: “Neither the number of misprojections nor the pattern of misprojections were significantly different between sema3fa−/− and nrp2a−/−;sema3fa−/− animals (Fig. 5A,B). Similarly, the number of misprojections and the pattern of misprojections were not significantly different between sema3fa−/− and nrp2b−/−;sema3fa−/− animals (Fig. 5C,D). Also, the following typographical errors, TRCP2 and TPRC2 on page 14 and TRCP2 on figure 6 caption were amended to TRPC2. This version of the paper now reflects these corrections to the original.
Fig. 6

Misprojecting growth cones fail to retract in nrp2a and in sema3fa mutants. A Live imaging sequences of nrp2a heterozygote and mutant siblings, showing misprojecting axons occupying the dorsal-medial OB. The yellow dotted lines indicate the dorsal boundary of the developing DZ and CZ protoglomeruli and denote the edge of the dorsal-medial OB region. Yellow arrows indicate misprojecting axons. B The cumulative time that the dorsal-medial OB is occupied by TRPC2-class OSNs is greater in nrp2a mutants as compared to nrp2a heterozygous siblings. C The maximum distance TRPC2-class axons project into the dorsal-medial OB is greater in nrp2a mutants as compared to heterozygotes. D Live imaging sequences of sema3fa heterozygote and mutant siblings, showing misprojecting axons occupying the dorsal-medial OB. E The cumulative time that the dorsal-medial OB is occupied by TRPC2-class OSNs is greater in sema3fa mutants as compared to heterozygous siblings. F The maximum distance TRPC2-class axons project into the dorsal-medial OB is greater in sema3fa mutants as compared to heterozygotes. G Model of average TRPC2-class axon locations in sema3fa heterozygotes and mutants during live imaging sequence. TRPC2-class axons are shown in green and magenta, and OMP-class axons in grey. The three TRPC2 surfaces encompass axon location probabilities, from most transparent to most opaque, of 5.6, 18.7, and 31.8%. Yellow dotted line represents the edge of the dorsal-medial OB region

Fig. 5

Both nrp2a and nrp2b act in the same pathway with sema3fa A Representative confocal sections of sema3fa mutant and nrp2a;sema3fa double mutant siblings. Yellow arrows indicate misprojecting axons. B The misprojection phenotype in nrp2a;sema3fa double mutants is not significantly different from sema3fa mutant siblings. C Representative confocal sections of sema3fa mutant and nrp2b;sema3fa double mutant siblings. Yellow arrows indicate misprojecting axons. D The misprojection phenotype in nrp2b;sema3fa double mutants is not significantly different from sema3fa mutant siblings. Model of average TRPC2-class axon locations in sema3fa heterozygotes and mutants during live imaging sequence. TRPC2-class axons are shown in green and magenta, and OMP-class axons in grey. The three TRCP2 surfaces encompass axon location probabilities, from most transparent to most opaque, of 5.6, 18.7, and 31.8%. Yellow dotted line represents the edge of the dorsal-medial OB region

Both nrp2a and nrp2b act in the same pathway with sema3fa A Representative confocal sections of sema3fa mutant and nrp2a;sema3fa double mutant siblings. Yellow arrows indicate misprojecting axons. B The misprojection phenotype in nrp2a;sema3fa double mutants is not significantly different from sema3fa mutant siblings. C Representative confocal sections of sema3fa mutant and nrp2b;sema3fa double mutant siblings. Yellow arrows indicate misprojecting axons. D The misprojection phenotype in nrp2b;sema3fa double mutants is not significantly different from sema3fa mutant siblings. Model of average TRPC2-class axon locations in sema3fa heterozygotes and mutants during live imaging sequence. TRPC2-class axons are shown in green and magenta, and OMP-class axons in grey. The three TRCP2 surfaces encompass axon location probabilities, from most transparent to most opaque, of 5.6, 18.7, and 31.8%. Yellow dotted line represents the edge of the dorsal-medial OB region Misprojecting growth cones fail to retract in nrp2a and in sema3fa mutants. A Live imaging sequences of nrp2a heterozygote and mutant siblings, showing misprojecting axons occupying the dorsal-medial OB. The yellow dotted lines indicate the dorsal boundary of the developing DZ and CZ protoglomeruli and denote the edge of the dorsal-medial OB region. Yellow arrows indicate misprojecting axons. B The cumulative time that the dorsal-medial OB is occupied by TRPC2-class OSNs is greater in nrp2a mutants as compared to nrp2a heterozygous siblings. C The maximum distance TRPC2-class axons project into the dorsal-medial OB is greater in nrp2a mutants as compared to heterozygotes. D Live imaging sequences of sema3fa heterozygote and mutant siblings, showing misprojecting axons occupying the dorsal-medial OB. E The cumulative time that the dorsal-medial OB is occupied by TRPC2-class OSNs is greater in sema3fa mutants as compared to heterozygous siblings. F The maximum distance TRPC2-class axons project into the dorsal-medial OB is greater in sema3fa mutants as compared to heterozygotes. G Model of average TRPC2-class axon locations in sema3fa heterozygotes and mutants during live imaging sequence. TRPC2-class axons are shown in green and magenta, and OMP-class axons in grey. The three TRPC2 surfaces encompass axon location probabilities, from most transparent to most opaque, of 5.6, 18.7, and 31.8%. Yellow dotted line represents the edge of the dorsal-medial OB region The original article [1] has been corrected.
  1 in total

1.  Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting.

Authors:  Ryan P Cheng; Puneet Dang; Alemji A Taku; Yoon Ji Moon; Vi Pham; Xiaohe Sun; Ethan Zhao; Jonathan A Raper
Journal:  Neural Dev       Date:  2022-01-03       Impact factor: 3.800

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.