Jamie E Collins1, Swastina Shrestha2, Elena Losina3, Robert G Marx4, Ali Guermazi5, Mohamed Jarraya6, Morgan H Jones2, Bruce A Levy7, Lisa A Mandl4, Emma E Williams2, Rick W Wright8, Kurt P Spindler9, Jeffrey N Katz1. 1. Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 2. Brigham and Women's Hospital, Boston, Massachusetts. 3. Brigham and Women's Hospital, Harvard Medical School, and Boston University School of Public Health, Boston, Massachusetts. 4. Hospital for Special Surgery and Weill Cornell Medicine, New York, New York. 5. Boston University School of Medicine, Boston, Massachusetts. 6. Massachusetts General Hospital, Boston, Massachusetts. 7. Mayo Clinic, Rochester, Minnesota. 8. Vanderbilt University Medical Center, Nashville, Tennessee. 9. Cleveland Clinic, Cleveland, Ohio.
Abstract
OBJECTIVE: To estimate the risk of magnetic resonance imaging (MRI)-based structural changes in knee osteoarthritis (OA) among individuals with meniscal tear and knee OA, using MRIs obtained at baseline and 18 and 60 months after randomization in a randomized controlled trial of arthroscopic partial meniscectomy (APM) versus physical therapy (PT). METHODS: We used data from the Meniscal Tear in Osteoarthritis Research (METEOR) trial. MRIs were read using the MRI OA Knee Score (MOAKS). We used linear mixed-effects models to examine the association between treatment group and continuous MOAKS summary scores, and Poisson regression to assess categorical changes in knee joint structure. Analyses assessed changes in OA between baseline and month 18 and between months 18 and 60. We performed both intention-to-treat and as-treated analyses. RESULTS: The analytic sample included 302 participants. For both treatment groups, more OA changes were seen during the early interval than during the later interval. ITT analysis revealed that, between baseline and month 18, APM was significantly associated with an increased risk of having a worsening cartilage surface area score, involving both any worsening across all knee joint subregions (risk ratio [RR] 1.35 [95% confidence interval (95% CI) 1.14, 1.61]) and the number of subregions damaged (RR 1.44 [95% CI 1.13, 1.85]) having a worsening effusion-synovitis score (RR 2.62 [95% CI 1.32, 5.21]), and having ≥1 additional subregion with osteophytes (RR 1.24 [95% CI 1.02, 1.50]). Significant associations were detected between months 18 and 60 only for having any subregion with a worsening osteophyte score (RR 1.28 [95% CI 1.04, 1.58]). CONCLUSION: These findings suggest that the association between APM and MRI-based structural changes in knee OA is most apparent during the initial 18 months after surgery. The reason for attenuation of this association over longer follow-up merits further investigation.
OBJECTIVE: To estimate the risk of magnetic resonance imaging (MRI)-based structural changes in knee osteoarthritis (OA) among individuals with meniscal tear and knee OA, using MRIs obtained at baseline and 18 and 60 months after randomization in a randomized controlled trial of arthroscopic partial meniscectomy (APM) versus physical therapy (PT). METHODS: We used data from the Meniscal Tear in Osteoarthritis Research (METEOR) trial. MRIs were read using the MRI OA Knee Score (MOAKS). We used linear mixed-effects models to examine the association between treatment group and continuous MOAKS summary scores, and Poisson regression to assess categorical changes in knee joint structure. Analyses assessed changes in OA between baseline and month 18 and between months 18 and 60. We performed both intention-to-treat and as-treated analyses. RESULTS: The analytic sample included 302 participants. For both treatment groups, more OA changes were seen during the early interval than during the later interval. ITT analysis revealed that, between baseline and month 18, APM was significantly associated with an increased risk of having a worsening cartilage surface area score, involving both any worsening across all knee joint subregions (risk ratio [RR] 1.35 [95% confidence interval (95% CI) 1.14, 1.61]) and the number of subregions damaged (RR 1.44 [95% CI 1.13, 1.85]) having a worsening effusion-synovitis score (RR 2.62 [95% CI 1.32, 5.21]), and having ≥1 additional subregion with osteophytes (RR 1.24 [95% CI 1.02, 1.50]). Significant associations were detected between months 18 and 60 only for having any subregion with a worsening osteophyte score (RR 1.28 [95% CI 1.04, 1.58]). CONCLUSION: These findings suggest that the association between APM and MRI-based structural changes in knee OA is most apparent during the initial 18 months after surgery. The reason for attenuation of this association over longer follow-up merits further investigation.
Authors: Jamie E Collins; Elena Losina; Robert G Marx; Ali Guermazi; Mohamed Jarraya; Morgan H Jones; Bruce A Levy; Lisa A Mandl; Scott D Martin; Rick W Wright; Kurt P Spindler; Jeffrey N Katz Journal: Arthritis Care Res (Hoboken) Date: 2020-05 Impact factor: 4.794
Authors: Bhushan R Deshpande; Jeffrey N Katz; Daniel H Solomon; Edward H Yelin; David J Hunter; Stephen P Messier; Lisa G Suter; Elena Losina Journal: Arthritis Care Res (Hoboken) Date: 2016-11-03 Impact factor: 4.794
Authors: Jeffrey N Katz; Robert H Brophy; Christine E Chaisson; Leigh de Chaves; Brian J Cole; Diane L Dahm; Laurel A Donnell-Fink; Ali Guermazi; Amanda K Haas; Morgan H Jones; Bruce A Levy; Lisa A Mandl; Scott D Martin; Robert G Marx; Anthony Miniaci; Matthew J Matava; Joseph Palmisano; Emily K Reinke; Brian E Richardson; Benjamin N Rome; Clare E Safran-Norton; Debra J Skoniecki; Daniel H Solomon; Matthew V Smith; Kurt P Spindler; Michael J Stuart; John Wright; Rick W Wright; Elena Losina Journal: N Engl J Med Date: 2013-03-18 Impact factor: 91.245
Authors: Frank W Roemer; Ali Guermazi; Jamie E Collins; Elena Losina; Michael C Nevitt; John A Lynch; Jeffrey N Katz; C Kent Kwoh; Virginia B Kraus; David J Hunter Journal: BMC Musculoskelet Disord Date: 2016-11-10 Impact factor: 2.362
Authors: Raine Sihvonen; Mika Paavola; Antti Malmivaara; Ari Itälä; Antti Joukainen; Juha Kalske; Heikki Nurmi; Jaanika Kumm; Niko Sillanpää; Tommi Kiekara; Aleksandra Turkiewicz; Pirjo Toivonen; Martin Englund; Simo Taimela; Teppo L N Järvinen Journal: Br J Sports Med Date: 2020-08-27 Impact factor: 13.800
Authors: Denise O'Connor; Renea V Johnston; Romina Brignardello-Petersen; Rudolf W Poolman; Sheila Cyril; Per O Vandvik; Rachelle Buchbinder Journal: Cochrane Database Syst Rev Date: 2022-03-03