Gabby B Joseph1, Charles E McCulloch2, Michael C Nevitt2, John Lynch2, Nancy E Lane3, Thomas M Link1. 1. Department of Radiology and Biomedical Imaging, University of California, San Francisco. 2. Department of Epidemiology and Biostatistics, University of California, San Francisco. 3. Department of Medicine, University of California, Davis.
Abstract
OBJECTIVE: To assess the effects of weight loss and weight gain on hip and knee radiographic changes, pain, and joint replacement over 4 years. METHODS: Participants (n=2752) from the Osteoarthritis (OA) Initiative were classified as those with weight gain (>5% gain), weight loss (>-5% loss), or as controls (-3 to 3% change) over four years. Generalized estimating equations (adjusted for age, gender, and BMI) were used to assess the relationship between weight change group and 4-year changes in knee radiographic OA (Kellgren Lawrence grade (KL)), hip OA (Croft summary grade), joint space narrowing (JSN), and joint pain. RESULTS: For radiographic knee OA, weight loss was associated with significantly lower odds of KL grade worsening over four years (OR=0.69, 95%CI=0.53-0.91, p=0.009), and weight gain was significantly associated with higher odds of medial knee JSN (OR=1.29, 95%CI=1.01-1.64, p=0.038) compared to controls. For knee pain, weight loss was significantly associated with knee pain resolution over four years (OR=1.40, 95%CI=1.06-1.86, p=0.019) while weight gain was associated with knee pain development (OR=1.34, 95%CI= 1.08-1.67, p=0.009) compared to controls. For all hip outcomes, no significant associations (p>0.05) were found with weight change groups. The associations between weight change group and total hip or total knee replacement were not significant (p>0.05). CONCLUSION: This large, longitudinal study (n=2752 with 4-year follow-up) suggests that weight loss may protect against, and weight gain may exacerbate radiographic and symptomatic knee OA, while weight change (5% threshold) does not have significant effects on hip OA. This article is protected by copyright. All rights reserved.
OBJECTIVE: To assess the effects of weight loss and weight gain on hip and knee radiographic changes, pain, and joint replacement over 4 years. METHODS: Participants (n=2752) from the Osteoarthritis (OA) Initiative were classified as those with weight gain (>5% gain), weight loss (>-5% loss), or as controls (-3 to 3% change) over four years. Generalized estimating equations (adjusted for age, gender, and BMI) were used to assess the relationship between weight change group and 4-year changes in knee radiographic OA (Kellgren Lawrence grade (KL)), hip OA (Croft summary grade), joint space narrowing (JSN), and joint pain. RESULTS: For radiographic knee OA, weight loss was associated with significantly lower odds of KL grade worsening over four years (OR=0.69, 95%CI=0.53-0.91, p=0.009), and weight gain was significantly associated with higher odds of medial knee JSN (OR=1.29, 95%CI=1.01-1.64, p=0.038) compared to controls. For knee pain, weight loss was significantly associated with knee pain resolution over four years (OR=1.40, 95%CI=1.06-1.86, p=0.019) while weight gain was associated with knee pain development (OR=1.34, 95%CI= 1.08-1.67, p=0.009) compared to controls. For all hip outcomes, no significant associations (p>0.05) were found with weight change groups. The associations between weight change group and total hip or total knee replacement were not significant (p>0.05). CONCLUSION: This large, longitudinal study (n=2752 with 4-year follow-up) suggests that weight loss may protect against, and weight gain may exacerbate radiographic and symptomatic knee OA, while weight change (5% threshold) does not have significant effects on hip OA. This article is protected by copyright. All rights reserved.
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