Literature DB >> 3524427

Complementation analysis of resistance to 5-fluorocytosine in Candida albicans.

W L Whelan, D Markie, K J Kwon-Chung.   

Abstract

A complementation test was devised to study allelism among the genetic determinants of resistance to 5-fluorocytosine in Candida albicans. Complementation was demonstrated in control hybrids produced by crossing a resistant strain that was deficient in cytosine deaminase activity with four other resistant strains deficient in UMP pyrophosphorylase activity. This complementation test was used to test allelism of the resistance determinants present in five clinical isolates. All were found to bear recessive alleles of the locus (FCY1) that determined 5-fluorocytosine resistance associated with low levels of UMP pyrophosphorylase activity.

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Year:  1986        PMID： 3524427      PMCID： PMC284142          DOI： 10.1128/AAC.29.5.726

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Mode of action of 5-fluorocytosine and mechanisms of resistance.

Authors:  A Polak; H J Scholer
Journal:  Chemotherapy       Date:  1975       Impact factor: 2.544

3.  Candida albicans resistance to 5-fluorocytosine: frequency of partially resistant strains among clinical isolates.

Authors:  K S Defever; W L Whelan; A L Rogers; E S Beneke; J M Veselenak; D R Soll
Journal:  Antimicrob Agents Chemother       Date:  1982-11       Impact factor: 5.191

4.  Susceptibility to 5-fluorocytosine and prevalence of serotype in 402 Candida albicans isolates from the United States.

Authors:  R L Stiller; J E Bennett; H J Scholer; M Wall; A Polak; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1982-09       Impact factor: 5.191

5.  Segregation of 5-fluorocytosine-resistance variants by Candida albicans.

Authors:  W L Whelan; E S Beneke; A L Rogers; D R Soll
Journal:  Antimicrob Agents Chemother       Date:  1981-06       Impact factor: 5.191

6.  Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae.

Authors:  R Jund; F Lacroute
Journal:  J Bacteriol       Date:  1970-06       Impact factor: 3.490

7.  Heterozygosity and segregation in Candida albicans.

Authors:  W L Whelan; R M Partridge; P T Magee
Journal:  Mol Gen Genet       Date:  1980

8.  Parasexual genetic analysis of Candida albicans by spheroplast fusion.

Authors:  R Poulter; K Jeffery; M J Hubbard; M G Shepherd; P A Sullivan
Journal:  J Bacteriol       Date:  1981-06       Impact factor: 3.490

9.  Hybridization of Candida albicans through fusion of protoplasts.

Authors:  A Sarachek; D D Rhoads; R H Schwarzhoff
Journal:  Arch Microbiol       Date:  1981-03       Impact factor: 2.552

10.  Natural heterozygosity in Candida albicans.

Authors:  W L Whelan; P T Magee
Journal:  J Bacteriol       Date:  1981-02       Impact factor: 3.490
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  5 in total

1.  Genetic analysis of prototrophic natural variants of Candida albicans.

Authors:  A K Goshorn; S Scherer
Journal:  Genetics       Date:  1989-12       Impact factor: 4.562

Review 2.  Genetics of Candida albicans.

Authors:  S Scherer; P T Magee
Journal:  Microbiol Rev       Date:  1990-09

3.  Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies.

Authors:  M B Kurtz; G Abruzzo; A Flattery; K Bartizal; J A Marrinan; W Li; J Milligan; K Nollstadt; C M Douglas
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

4.  A Candida albicans dispersed, repeated gene family and its epidemiologic applications.

Authors:  S Scherer; D A Stevens
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

5.  Correlation between the presence of a self-splicing intron in the 25S rDNA of C.albicans and strains susceptibility to 5-fluorocytosine.

Authors:  S Mercure; S Montplaisir; G Lemay
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971
  5 in total

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