Hormones in milk.

Protein hormones (especially prolactin) and steroid hormones (gestagens, estrogens, corticoids, and androgens) can be detected by bioassay and radioimmunoassay in milk in a variety of species. In addition, milk contains vitamin D and beta-casomorphins (opiate-like peptides). It has been assumed that most of the hormones are transferred into milk by diffusion. However, evidence is available for active mechanisms like those for progesterone in goats and prolactin in cows. Most of the hormone profiles in milk are similar to the ones in blood plasma. Hormone concentrations in milk seem to be a good estimate of the average hormone content in plasma, especially for the measurement of longer-lasting secretory activities like progesterone and estrogen release during the estrous cycle or seasonal changes of prolactin in ruminants. Determination of progesterone and estrone sulfate in milk serves as a diagnostic tool in fertility control, especially in cows. Enzyme immunoassay kits are available for this monitoring purpose. Exogenously administered hormones are also transferred into milk. Residue studies have shown that the dilution is so great that it may be assumed that there is no potential risk for the consumer.