Younghee Park1, Kiryun Kim2, Hae Jin Park3, Ha-Jung Chun4, Dongho Choi5, Kyubo Kim6. 1. Department of Radiation Oncology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea. 2. Hanyang University College of Medicine, Seoul, Republic of Korea. 3. Department of Radiation Oncology, Hanyang University College of Medicine, Seoul, Republic of Korea; haejinpark@hanyang.ac.kr. 4. Department of Radiation Oncology, Hanyang University College of Medicine, Seoul, Republic of Korea. 5. Department of Surgery, Hanyang University College of Medicine, Seoul, Republic of Korea. 6. Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Abstract
AIM: To identify prognostic factors for surgically resected gallbladder cancer (GBC). PATIENTS AND METHODS: Medical records of 66 patients with GBC undergoing potentially curative resection between 2001 and 2017 were retrospectively reviewed. RESULTS: After a median follow-up of 39.9 months (range=0.5-216.4 months), 22 locoregional recurrences and 25 distant metastases occurred. Adjuvant radiotherapy and adjuvant chemotherapy failed to prove efficacy in all patient groups. In patients with stage III-IV GBC, adjuvant chemotherapy showed a marginally positive effect on locoregional control (p=0.064), and was significantly beneficial for overall survival (p=0.040), and adjuvant treatment improved both locoregional control and overall survival (p=0.029 and p=0.005, respectively). On multivariate analysis, a negative resection margin was a significant prognostic factor for superior local control, and disease-free and overall survival (p=0.003, p=0.010 and p=0.005, respectively) and adjuvant treatment was associated with improved overall survival (p=0.018). CONCLUSION: Adjuvant treatment is recommended for patients with stage III-IV GBC following curative surgical resection.
AIM: To identify prognostic factors for surgically resected gallbladder cancer (GBC). PATIENTS AND METHODS: Medical records of 66 patients with GBC undergoing potentially curative resection between 2001 and 2017 were retrospectively reviewed. RESULTS: After a median follow-up of 39.9 months (range=0.5-216.4 months), 22 locoregional recurrences and 25 distant metastases occurred. Adjuvant radiotherapy and adjuvant chemotherapy failed to prove efficacy in all patient groups. In patients with stage III-IV GBC, adjuvant chemotherapy showed a marginally positive effect on locoregional control (p=0.064), and was significantly beneficial for overall survival (p=0.040), and adjuvant treatment improved both locoregional control and overall survival (p=0.029 and p=0.005, respectively). On multivariate analysis, a negative resection margin was a significant prognostic factor for superior local control, and disease-free and overall survival (p=0.003, p=0.010 and p=0.005, respectively) and adjuvant treatment was associated with improved overall survival (p=0.018). CONCLUSION: Adjuvant treatment is recommended for patients with stage III-IV GBC following curative surgical resection.
Authors: Yuhree Kim; Neda Amini; Ana Wilson; Georgios A Margonis; Cecilia G Ethun; George Poultsides; Thuy Tran; Kamran Idrees; Chelsea A Isom; Ryan C Fields; Bradley Krasnick; Sharon M Weber; Ahmed Salem; Robert C G Martin; Charles Scoggins; Perry Shen; Harveshp D Mogal; Carl Schmidt; Eliza Beal; Ioannis Hatzaras; Rivfka Shenoy; Kenneth Cardona; Shishir K Maithel; Timothy M Pawlik Journal: Ann Surg Oncol Date: 2016-05-11 Impact factor: 5.344
Authors: William R Jarnagin; Leyo Ruo; Sarah A Little; David Klimstra; Michael D'Angelica; Ronald P DeMatteo; Raquel Wagman; Leslie H Blumgart; Yuman Fong Journal: Cancer Date: 2003-10-15 Impact factor: 6.860
Authors: Se-Il Go; Young Saing Kim; In Gyu Hwang; Eun Young Kim; Sung Yong Oh; Jun Ho Ji; Haa-Na Song; Se Hoon Park; Joon Oh Park; Jung Hun Kang Journal: Cancer Res Treat Date: 2016-02-12 Impact factor: 4.679
Authors: Tae Hyun Kim; Sang Myung Woo; Woo Jin Lee; Eun Sang Oh; Sang Hee Youn; Sung Ho Moon; Sang Soo Kim; Sung Sik Han; Sang-Jae Park; Dae Yong Kim Journal: Sci Rep Date: 2019-08-13 Impact factor: 4.379