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Literature DB >> 352377

Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.

Abstract

1 Plasma concentrations of diazepam and its metabolite, desmethyldiazepam, have been measured in both in- and out-patient groups treated with diazepam for periods varying between 1 month and 10 years. 2 The diazepam concentration was directly related to the dose of diazepam ingested and inversely related to the age of the patient. 3 A highly significant relationship was obtained between the concentration of desmethyldiazepam and diazepam. 4 The plasma concentrations of both diazepam and its metabolite were independent of sex, duration fo therapy and patient group.

Entities: Chemical Species

Mesh：

Substances：
Nordazepam
Diazepam

Year: 1978 PMID： 352377 PMCID： PMC1429378 DOI： 10.1111/j.1365-2125.1978.tb01684.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

10 in total

1. Rapid micro-method for the measurement of diazepam and desmethyldiazepam in blood plasma by gas-liquid chromatography.

Authors: D M Rutherford
Journal: J Chromatogr Date: 1977-07-21

2. The concentrations of diazepam and its metabolites in the plasma after an acute and chronic administration.

Authors: J Kanto; E Iisalo; V Lehtinen; J Salminen
Journal: Psychopharmacologia Date: 1974-04-08

3. Diazepam metabolism in normal man. II. Serum concentration and clinical effect after oral administration and cumulation.

Authors: L Hillestad; T Hansen; H Melsom
Journal: Clin Pharmacol Ther Date: 1974-09 Impact factor: 6.875

4. Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration.

Authors: L Hillestad; T Hansen; H Melsom; A Drivenes
Journal: Clin Pharmacol Ther Date: 1974-09 Impact factor: 6.875

5. Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine.

Authors: I A Zingales
Journal: J Chromatogr Date: 1973-01-03

6. Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administrations.

Authors: S A Kaplan; M L Jack; K Alexander; R E Weinfeld
Journal: J Pharm Sci Date: 1973-11 Impact factor: 3.534

7. Plasma concentrations of benzodiazepines.

Authors: A J Bond; D M Hailey; M H Lader
Journal: Br J Clin Pharmacol Date: 1977-02 Impact factor: 4.335

8. The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

Authors: U Klotz; G R Avant; A Hoyumpa; S Schenker; G R Wilkinson
Journal: J Clin Invest Date: 1975-02 Impact factor: 14.808

9. Comparison of the pharmacokinetics of diazepam after single and subchronic doses.

Authors: U Klotz; K H Antonin; P R Bieck
Journal: Eur J Clin Pharmacol Date: 1976-06-15 Impact factor: 2.953

Review 10. Pharmacokinetics in the elderly.

Authors: J Crooks; K O'Malley; I H Stevenson
Journal: Clin Pharmacokinet Date: 1976 Impact factor: 6.447

10 in total

1. Radioreceptor assay for checking benzodiazepine intake.

Authors: S J Dencker; G Johansson
Journal: Psychopharmacology (Berl) Date: 1989 Impact factor: 4.530

2. Clearance of diazepam can be impaired by its major metabolite desmethyldiazepam.

Authors: U Klotz; I Reimann
Journal: Eur J Clin Pharmacol Date: 1981 Impact factor: 2.953

3. Time-course of transplacental passage of diazepam: Influence of injection-delivery interval on neonatal drug concentrations.

Authors: O M Bakke; K Haram
Journal: Clin Pharmacokinet Date: 1982 Jul-Aug Impact factor: 6.447

Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.

1. Rapid micro-method for the measurement of diazepam and desmethyldiazepam in blood plasma by gas-liquid chromatography.

2. The concentrations of diazepam and its metabolites in the plasma after an acute and chronic administration.

3. Diazepam metabolism in normal man. II. Serum concentration and clinical effect after oral administration and cumulation.

4. Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration.

5. Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine.

6. Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administrations.

7. Plasma concentrations of benzodiazepines.

8. The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

9. Comparison of the pharmacokinetics of diazepam after single and subchronic doses.

Review 10. Pharmacokinetics in the elderly.

1. Radioreceptor assay for checking benzodiazepine intake.

2. Clearance of diazepam can be impaired by its major metabolite desmethyldiazepam.

3. Time-course of transplacental passage of diazepam: Influence of injection-delivery interval on neonatal drug concentrations.

4. Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors.

Review 5. Time-dependence in benzodiazepine pharmacokinetics. Mechanisms and clinical significance.

6. Disposition of intravenous diazepam in young men and women.

Review 7. Benzodiazepine dependence. A review of the evidence.

8. Comparison of the placental transfer of thiopental and diazepam in caesarean section.

9. Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy.

10. Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin.