Literature DB >> 35237358

Retracted: Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats.

Behavioural Neurology.   

Abstract

[This retracts the article DOI: 10.1155/2020/9370891.].
Copyright © 2022 Behavioural Neurology.

Entities:  

Year:  2022        PMID: 35237358      PMCID: PMC8885268          DOI: 10.1155/2022/9840256

Source DB:  PubMed          Journal:  Behav Neurol        ISSN: 0953-4180            Impact factor:   3.342


Behavioural Neurology and the authors have retracted the article titled “Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats” [1], due to concerns with the methodology which invalidates the conclusions. Following publication of the article, the authors identified concerns that the use of sodium pentobarbital as an anaesthetic may interfere with the function of propofol due to its interaction with the GABA-A receptor [2, 3]. The conclusions drawn in the article are therefore considered unreliable. The authors apologize for this error and agree to the retraction of the article, which is also with the agreement of the editorial board.
  3 in total

1.  Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABAA receptors.

Authors:  Francisco Javier Sierra-Valdez; J C Ruiz-Suárez; Ilse Delint-Ramirez
Journal:  Biochim Biophys Acta       Date:  2016-07-25

2.  Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture.

Authors:  R L MacDonald; C J Rogers; R E Twyman
Journal:  J Physiol       Date:  1989-10       Impact factor: 5.182

3.  Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats.

Authors:  Yunlong Xing; Kai Li; Yuan Jiao; Zinan Li
Journal:  Behav Neurol       Date:  2020-02-20       Impact factor: 3.342

  3 in total

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