Literature DB >> 35236964

Therapeutically harnessing extracellular vesicles.

Lesley Cheng1, Andrew F Hill2,3.   

Abstract

The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of significant clinical relevance. The potential of harnessing EVs in the diagnosis and treatment of diseases - including cancer and neurological and cardiovascular disorders - is now being recognized. Accordingly, the applications of EVs as therapeutic targets, biomarkers, novel drug delivery agents and standalone therapeutics are being actively explored. This Review provides a brief overview of the characteristics and physiological functions of the various classes of EV, focusing on their association with disease and emerging strategies for their therapeutic exploitation.
© 2022. Springer Nature Limited.

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Year:  2022        PMID： 35236964     DOI： 10.1038/s41573-022-00410-w

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  237 in total

1.  Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons.

Authors:  Karine Laulagnier; Charlotte Javalet; Fiona J Hemming; Mathilde Chivet; Gaëlle Lachenal; Béatrice Blot; Christine Chatellard; Rémy Sadoul
Journal:  Cell Mol Life Sci       Date:  2017-09-27       Impact factor: 9.261

2.  Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells.

Authors:  Bas W M van Balkom; Olivier G de Jong; Michiel Smits; Jolanda Brummelman; Krista den Ouden; Petra M de Bree; Monique A J van Eijndhoven; D Michiel Pegtel; Willem Stoorvogel; Thomas Würdinger; Marianne C Verhaar
Journal:  Blood       Date:  2013-03-26       Impact factor: 22.113

3.  Human tumor virus utilizes exosomes for intercellular communication.

Authors:  David G Meckes; Kathy H Y Shair; Aron R Marquitz; Che-Pei Kung; Rachel H Edwards; Nancy Raab-Traub
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-08       Impact factor: 11.205

4.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.

Authors:  Hadi Valadi; Karin Ekström; Apostolos Bossios; Margareta Sjöstrand; James J Lee; Jan O Lötvall
Journal:  Nat Cell Biol       Date:  2007-05-07       Impact factor: 28.824

5.  Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells.

Authors:  Xiaohong Wang; Wei Huang; Guansheng Liu; Wenfeng Cai; Ronald W Millard; Yigang Wang; Jiang Chang; Tianqing Peng; Guo-Chang Fan
Journal:  J Mol Cell Cardiol       Date:  2014-05-10       Impact factor: 5.000

6.  B lymphocytes secrete antigen-presenting vesicles.

Authors:  G Raposo; H W Nijman; W Stoorvogel; R Liejendekker; C V Harding; C J Melief; H J Geuze
Journal:  J Exp Med       Date:  1996-03-01       Impact factor: 14.307

7.  Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism.

Authors:  Felix Jansen; Xiaoyan Yang; Katharina Baumann; David Przybilla; Theresa Schmitz; Anna Flender; Kathrin Paul; Adil Alhusseiny; Georg Nickenig; Nikos Werner
Journal:  J Cell Mol Med       Date:  2015-06-17       Impact factor: 5.310

8.  Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology.

Authors:  Jennifer Ngolab; Ivy Trinh; Edward Rockenstein; Michael Mante; Jazmin Florio; Margarita Trejo; Deborah Masliah; Anthony Adame; Eliezer Masliah; Robert A Rissman
Journal:  Acta Neuropathol Commun       Date:  2017-06-09       Impact factor: 7.801

9.  Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.

Authors:  Zuzana Krejciova; James Alibhai; Chen Zhao; Robert Krencik; Nina M Rzechorzek; Erik M Ullian; Jean Manson; James W Ironside; Mark W Head; Siddharthan Chandran
Journal:  J Exp Med       Date:  2017-11-15       Impact factor: 14.307

10.  Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.

Authors:  Johan Skog; Tom Würdinger; Sjoerd van Rijn; Dimphna H Meijer; Laura Gainche; Miguel Sena-Esteves; William T Curry; Bob S Carter; Anna M Krichevsky; Xandra O Breakefield
Journal:  Nat Cell Biol       Date:  2008-11-16       Impact factor: 28.824
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  16 in total

Review 1.  Efficacy and safety of small extracellular vesicle interventions in wound healing and skin regeneration: A systematic review and meta-analysis of animal studies.

Authors:  Maimonah Eissa Al-Masawa; Mohammed Abdullah Alshawsh; Chiew Yong Ng; Angela Min Hwei Ng; Jhi Biau Foo; Ubashini Vijakumaran; Revatyambigai Subramaniam; Nur Azurah Abdul Ghani; Kenneth Whitaker Witwer; Jia Xian Law
Journal:  Theranostics       Date:  2022-09-06       Impact factor: 11.600

2.  Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with 89Zr Radioisotope in Mice and Rats.

Authors:  Hojun Choi; Myung-Yoon Kim; Dae-Hwan Kim; Hanoul Yun; Byung-Koo Oh; Su-Bin Kim; In-Ho Song; Hyun-Soo Park; Sang-Eun Kim; Cheolhyoung Park; Chulhee Choi
Journal:  Pharmaceutics       Date:  2022-05-24       Impact factor: 6.525

3.  PAI/MRI Visualization of Tumor Derived Cellular Microvesicles with Endogenous Biopolymer Nanoparticles Modification.

Authors:  Shuxin Lv; Jinghua Sun; Chunyan Guo; Yufei Qin; Ruiping Zhang
Journal:  Int J Nanomedicine       Date:  2022-06-30

4.  Amelioration of ligamentum flavum hypertrophy using umbilical cord mesenchymal stromal cell-derived extracellular vesicles.

Authors:  Cheng Ma; Xin Qi; Yi-Fan Wei; Zhi Li; He-Long Zhang; He Li; Feng-Lei Yu; Ya-Nan Pu; Yong-Can Huang; Yong-Xin Ren
Journal:  Bioact Mater       Date:  2022-04-08

Review 5.  Mesenchymal Stem Cells and Their Small Extracellular Vesicles as Crucial Immunological Efficacy for Hepatic Diseases.

Authors:  Yuting Tang; Peipei Wu; Linli Li; Wenrong Xu; Jiajia Jiang
Journal:  Front Immunol       Date:  2022-05-06       Impact factor: 8.786

Review 6.  Hydrogels for Exosome Delivery in Biomedical Applications.

Authors:  Yaxin Xie; Qiuyue Guan; Jiusi Guo; Yilin Chen; Yijia Yin; Xianglong Han
Journal:  Gels       Date:  2022-05-24

Review 7.  Circulating Exosome Cargoes Contain Functionally Diverse Cancer Biomarkers: From Biogenesis and Function to Purification and Potential Translational Utility.

Authors:  Megan I Mitchell; Junfeng Ma; Claire L Carter; Olivier Loudig
Journal:  Cancers (Basel)       Date:  2022-07-10       Impact factor: 6.575

Review 8.  Extrachromosomal circular DNA (eccDNA): an emerging star in cancer.

Authors:  Ruomeng Li; Ying Wang; Jing Li; Xikun Zhou
Journal:  Biomark Res       Date:  2022-07-26

Review 9.  Clinical potential of the Hippo-YAP pathway in bladder cancer.

Authors:  Xin Cheng; Kecheng Lou; Liang Ding; Xiaofeng Zou; Ruohui Huang; Gang Xu; Junrong Zou; Guoxi Zhang
Journal:  Front Oncol       Date:  2022-07-15       Impact factor: 5.738

10.  Editorial: New insights into extracellular vesicles in cardiovascular disease: Molecular basis, diagnosis and therapy.

Authors:  Yang Shen; Xiaoheng Liu
Journal:  Front Cell Dev Biol       Date:  2022-08-25
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