Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis.

The authors reply: We appreciate your opinion and your suggestions, and I’d like to reply to the points that you mentioned. We in this meta-analysis assessed the association between polycystic ovary syndrome (PCOS) and risk of attention-deficit/hyperactivity disorder (ADHD) in offspring compared with women without PCOS [1]. Hergüner et al. [2] aimed to compare ADHD symptoms between women with PCOS and controls. However, Hergüner et al. [2] measured ADHD symptoms based on 18 items on Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for ADHD. DSM-IV is a diagnostic critera for ADHD [3,4]. Therefore, the symptoms of ADHD based on DSM-IV criteria indicate the diagnosis of ADHD. On the other, there was a significant association between PCOS and risk ADHD in 5 of 6 included articles. Therefore, it cannot introduce bias and a false conclusion.