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Literature DB >> 35235427

Epigenetic regulation and targeting of ECM for cancer therapy.

Abstract

The tumor microenvironment (TME) composed of different types of cells embedded in extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is made of a variety of proteins that provide structural support to the cells and regulate biological functions by modulating the cross talk among cells, thus effecting tumor growth and progression. In this mini-review, the author discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and the prospects of targeting them for cancer therapy.

Entities: Chemical

Keywords: epigenetics; extracellular matrix; fibrous; therapy; tumor microenvironment

Mesh：

Year: 2022 PMID： 35235427 PMCID： PMC8993518 DOI： 10.1152/ajpcell.00022.2022

Source DB: PubMed Journal: Am J Physiol Cell Physiol ISSN： 0363-6143 Impact factor: 4.249

78 in total

Review 1. The collagen family.

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Journal: Cold Spring Harb Perspect Biol Date: 2011-01-01 Impact factor: 10.005

Review 2. Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

Authors: Diane E Handy; Rita Castro; Joseph Loscalzo
Journal: Circulation Date: 2011-05-17 Impact factor: 29.690

3. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.

Authors: Yanxia Zhao; Jinghong Cao; Alexander Melamed; Michael Worley; Allison Gockley; Dennis Jones; Hadi T Nia; Yanling Zhang; Triantafyllos Stylianopoulos; Ashwin S Kumar; Fotios Mpekris; Meenal Datta; Yao Sun; Limeng Wu; Xing Gao; Oladapo Yeku; Marcela G Del Carmen; David R Spriggs; Rakesh K Jain; Lei Xu
Journal: Proc Natl Acad Sci U S A Date: 2019-01-18 Impact factor: 11.205

4. A dose-escalation and signal-generating study of the immunocytokine L19-IL2 in combination with dacarbazine for the therapy of patients with metastatic melanoma.

Authors: Thomas K Eigentler; Benjamin Weide; Filippo de Braud; Gianluca Spitaleri; Antonella Romanini; Annette Pflugfelder; Reinerio González-Iglesias; Annaelisa Tasciotti; Leonardo Giovannoni; Kathrin Schwager; Valeria Lovato; Manuela Kaspar; Eveline Trachsel; Hans D Menssen; Dario Neri; Claus Garbe
Journal: Clin Cancer Res Date: 2011-10-25 Impact factor: 12.531

Review 5. miRNAs regulate expression and function of extracellular matrix molecules.

Authors: Zina Jeyapalan Rutnam; Thomas N Wight; Burton B Yang
Journal: Matrix Biol Date: 2012-11-15 Impact factor: 11.583

6. Epigenetic Modulation of Collagen 1A1: Therapeutic Implications in Fibrosis and Endometriosis.

Authors: Ye Zheng; Zaraq Khan; Valentina Zanfagnin; Luiz F Correa; Abigail A Delaney; Gaurang S Daftary
Journal: Biol Reprod Date: 2016-03-02 Impact factor: 4.285

Review 7. Illustrating the interplay between the extracellular matrix and microRNAs.

Authors: Anna M Piccinini; Kim S Midwood
Journal: Int J Exp Pathol Date: 2014-04-25 Impact factor: 1.925

8. Adhesion and Invasion of Breast and Oesophageal Cancer Cells Are Impeded by Anti-LRP/LR-Specific Antibody IgG1-iS18.

Authors: Thandokuhle Khumalo; Uwe Reusch; Stefan Knackmuss; Melvyn Little; Robin B Veale; Stefan F T Weiss
Journal: PLoS One Date: 2013-06-18 Impact factor: 3.240

Review 9. Clinical Trials Targeting the Stroma in Pancreatic Cancer: A Systematic Review and Meta-Analysis.

Authors: Madelaine G van Mackelenbergh; Charlotte I Stroes; René Spijker; Casper H J van Eijck; Johanna W Wilmink; Maarten F Bijlsma; Hanneke W M van Laarhoven
Journal: Cancers (Basel) Date: 2019-04-26 Impact factor: 6.639

10. Identification and characterization of a unique role for EDB fibronectin in phagocytosis.

Authors: Sabrina Kraft; Verena Klemis; Carla Sens; Thorsten Lenhard; Christian Jacobi; Yvonne Samstag; Guido Wabnitz; Michael Kirschfink; Reinhard Wallich; G Maria Hänsch; Inaam A Nakchbandi
Journal: J Mol Med (Berl) Date: 2015-12-05 Impact factor: 4.599

1 in total

1. ZIC5 promotes human hepatocellular carcinoma cell proliferation through upregulating COL1A1.

Authors: Wenping Song; Weijiang Yu; Ding Li; Cheng Cheng; Xuan Wu; Jinhua Chen; Wenzhou Zhang
Journal: J Gastrointest Oncol Date: 2022-06

1 in total