Jin Liu1, Qiang Li1, Weihua Chen2, Haozhang Huang1,3, Yaren Yu4, Bo Wang1, Guoxiao Liang5, Wenguang Lai6, Liwei Liu1,3, Ming Ying1, Haiyan Wei7, Zhigang Huang5, Jindong Ni5, Jiyan Chen1,3,8, Shiqun Chen9, Yong Liu10,11,12. 1. Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Science, South China University of Technology, Guangzhou, 510080, China. 2. The Third Clinical Medical College, Fujian Medical University, Fuzhou, 350000, China. 3. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China. 4. Department of Cardiology, The First People's Hospital of Foshan, No.81 of Lingnan Road, Chancheng District, Foshan, 528000, Guangdong Province, China. 5. Guangdong Medical University, Dongguan, 524023, China. 6. Guangdong Provincial People's Hospital, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510515, China. 7. The First People's Hospital of Kashgar Prefecture, Kashi, 844000, China. 8. Guangdong Provincial People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510100, China. 9. Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Science, South China University of Technology, Guangzhou, 510080, China. shiqunchen@126.com. 10. Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Science, South China University of Technology, Guangzhou, 510080, China. liuyong@gdph.org.cn. 11. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China. liuyong@gdph.org.cn. 12. Guangdong Provincial People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510100, China. liuyong@gdph.org.cn.
Abstract
PURPOSE: Acute kidney disease (AKD) is an important state in the evolving kidney diseases. However, there is limited data on the incidence and prognosis of AKD following coronary angiography (CAG). Therefore, we aim to characterize the incidence and prognosis of AKD across a large population of CAG patients. METHODS: The consecutive patients with baseline and following measurement of serum creatinine (Scr) between 7 and 90 days after CAG procedure were included. The AKD was defined as a decrease in glomerular filtration rate by > 35%, or an increase in Scr of > 50% (from 7 to 90 days). Survival curves, univariate and multivariable cox regressions were used to assess the association between AKD and mortality. RESULTS: Among 9223 patients (male, 60.3%, mean age, 61.7 ± 9.6), 1540 had AKD. During a median follow-up of 5.4 (IQR 2.2-8.6) years, 1562 (16.9%) patients died. The mortality among the patients with AKD was higher than the non-AKD group (24.8% vs. 15.4%, p < 0.001). AKD was independently associated with a significantly increased risk of all-cause mortality (adjusted hazard ratio [aHR], 1.57; 95% CI 1.39-1.78; p < 0.001). CONCLUSIONS: Our study suggested that AKD is commonly observed after CAG and increased half mortality risk than those without AKD. More attention needs to be paid to patients suffering from AKD.
PURPOSE: Acute kidney disease (AKD) is an important state in the evolving kidney diseases. However, there is limited data on the incidence and prognosis of AKD following coronary angiography (CAG). Therefore, we aim to characterize the incidence and prognosis of AKD across a large population of CAG patients. METHODS: The consecutive patients with baseline and following measurement of serum creatinine (Scr) between 7 and 90 days after CAG procedure were included. The AKD was defined as a decrease in glomerular filtration rate by > 35%, or an increase in Scr of > 50% (from 7 to 90 days). Survival curves, univariate and multivariable cox regressions were used to assess the association between AKD and mortality. RESULTS: Among 9223 patients (male, 60.3%, mean age, 61.7 ± 9.6), 1540 had AKD. During a median follow-up of 5.4 (IQR 2.2-8.6) years, 1562 (16.9%) patients died. The mortality among the patients with AKD was higher than the non-AKD group (24.8% vs. 15.4%, p < 0.001). AKD was independently associated with a significantly increased risk of all-cause mortality (adjusted hazard ratio [aHR], 1.57; 95% CI 1.39-1.78; p < 0.001). CONCLUSIONS: Our study suggested that AKD is commonly observed after CAG and increased half mortality risk than those without AKD. More attention needs to be paid to patients suffering from AKD.
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